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Summary: Authored: Gillespie, ME, 2007-07-25 19:42:36
Summary: Reviewed: Kumar, A, 2007-01-31 22:47:49
Summary: Edited: Matthews, L, 2011-05-06
Summary: Authored: Garapati, P V, 2008-09-05 06:02:05
Summary: Edited: Garapati, P V, 2008-07-30 10:22:58
Summary: Reviewed: Kunapuli, SP, 2010-06-07
Summary: Activation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane. Ca2+ store release involves phospholipase C (PLC)-mediated production of inositol-1,4,5-trisphosphate (IP3), which in turn stimulates IP3 receptor channels to release Ca2+ from intracellular stores. This is followed by Ca2+ entry into the cell through plasma membrane calcium channels, a process referred to as store-operated calcium entry (SOCE). Stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and the four transmembrane channel protein Orai1 are the key players in platelet SOCE. Other major Ca2+ entry mechanisms are mediated by the direct receptor-operated calcium (ROC) channel, P2X1 and transient receptor potential channels (TRPCs).
Summary: Authored: May, B, 2011-07-11