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Pathway: Arachidonate production from DAG

Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1. more...

Reviewed: Akkerman, JW, 2009-09-04

Authored: Jupe, S, 2009-06-11

Edited: Jupe, S, 2009-09-09

References:

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes Br J Pharmacol 134:664-72 [PubMed]
Release of arachidonate from diglyceride in human platelets requires the sequential action of a diglyceride lipase and a monoglyceride lipase Biochem Biophys Res Commun 100:1688-95 [PubMed]
Differential hydrolysis of phospholipid molecular species during activation of human platelets with thrombin and collagen J Biol Chem 262:2262-9 [PubMed]
Diacylglycerol metabolism and arachidonic acid release in human fetal membranes and decidua vera J Biol Chem 256:7316-21 [PubMed]