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Pathway: Tie2 Signaling

The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.more...

These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.

Reviewed: Trowsdale, J, 2008-02-26 12:02:59

Authored: Garapati, P V, de Bono, B, 2008-03-05 10:26:56

References:

Angiopoietin and Tie signaling pathways in vascular development Matrix Biol 20:319-25 [PubMed]
Tek/Tie2 signaling: new and old partners Cancer Metastasis Rev 19:13-7 [PubMed]
The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development Semin Cell Dev Biol 13:19-27 [PubMed]
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene 17(9):1097-108 [PubMed]