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Searched for: REACTOME AND mRNA Splicing [All Organisms, All Data Sources]

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Pathways (77)Molecules (156)
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Pathway: mRNA Splicing  from Reactome  [183 molecules]
The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing.

Summary:  The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway.

  • ... mRNA Splicing ...
  • ... Reactome ...
  • ... reactome.
  • The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. ... Most of the mRNA is spliced by the major pathway. ... of this instance in Reactome: http://www. ...reactome.
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Pathway: Processing of Capped Intron-Containing Pre-mRNA  from Reactome  [254 molecules]
Authored: Carmichael, GG, Hammarskjold, ML, Hastings, M, Krainer, AR, Marzluff, WF, Wahle, E, Zhang, Z, 2003-06-05 08:30:31.

Summary:  Authored: Carmichael, GG, Hammarskjold, ML, Hastings, M, Krainer, AR, Marzluff, WF, Wahle, E, Zhang, Z, 2003-06-05 08:30:31

  • Processing of Capped Intron-Containing Pre-mRNA ...
  • ... Reactome ...
  • ... reactome. ...-transcriptional pre-mRNA splicing is not obligatory. ... Pre-mRNA splicing begins co-transcriptionally. ...-mRNA ...
  • ... cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. ... the gene in which splicing factors can be recruited.
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Pathway: Formation and Maturation of mRNA Transcript  from Reactome  [403 molecules]
Edited: Joshi-Tope, G, 0000-00-00 00:00:00.

Summary:  Edited: Joshi-Tope, G, 0000-00-00 00:00:00

  • Formation and Maturation of mRNA Transcript ...
  • ... Reactome ...
  • ... reactome.
  • Formation and Maturation of mRNA Transcript. ... translatable mRNA. ... These comprise capping, splicing out of introns from within the body of the pre-mRNA. ... of capping, splicing and polyadenylation. ...p The export of mRNA from the nucleus and mRNA splicing are also. ... to the recruitment of the mRNA export factor ALY to the mRNA during the splicing reaction, which in turn ...
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Pathway: mRNA Splicing - Major Pathway  from Reactome  [168 molecules]
The splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'.

Summary:  The splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the range of 3-5 million kDa. Small nuclear RNAs (snRNAs) U1, U2, U4, U5, and U6, are some of the best characterized components of spliceosomes, and are known to play key roles not only in spliceosomal assembly, but also in the two catalytic steps of the splicing reaction. Over 150 proteins have been detected in spliceosomes, and only a subset of these has been characterized. The characterization, and the determination of the functions of the protein components of the spliceosome, is still work in progress.

  • ... mRNA Splicing - Major Pathway ...
  • ... pre-mRNA splicing ...
  • U2 Dependent Splicing ...
  • ... Reactome ...
  • ... reactome.
  • The splicing of pre-mRNA occurs within a large, very dynamic complex. ... roles not only in spliceosomal assembly, but also in the two catalytic steps of the splicing reaction. ... proteins assemble on the pre-mRNA in a stepwise pathway.
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Pathway: mRNA Splicing - Minor Pathway  from Reactome  [68 molecules]
The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway.

Summary:  The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes.

  • ... mRNA Splicing - Minor Pathway ...
  • U12 Dependent Splicing ...
  • ... Reactome ...
  • ... reactome.
  • The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC.
  • Pre-mRNA splicing: the discovery.
  • AT-AC pre-mRNA splicing mechanisms and conservation of minor introns ...
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Pathway: Inhibition of Host mRNA Processing and RNA Silencing  from Reactome  [6 molecules]
The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs.

Summary:  The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus.

  • Inhibition of Host mRNA Processing and RNA Silencing ...
  • ... Reactome ...
  • ... reactome.
  • Inhibition of Host mRNA Processing. ... Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport 271828.
  • The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing ...
  • ... efficient 3' end processing of host pre-mRNAs. ... NS1 also inhibits the splicing of pre-mRNAs ...
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Pathway: mRNA Capping  from Reactome  [60 molecules]
The 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures.

Summary:  The 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. The cap is thought to influence splicing of the first intron, and is bound by 'cap-binding' proteins, CBP80 and CBP20, in the nucleus. The cap is important for translation initiation, and it also interacts with the poly(A)terminus, via proteins, resulting in circularization of the mRNA to facilitate multiple rounds of translation. The cap is also important for mRNA stability, protecting it from 5' to 3' nucleases, and is required for mRNA export to the cytoplasm.

  • ... mRNA Capping ...
  • ... Reactome ...
  • ... reactome.
  • The 5'-ends of all eukaryotic pre-mRNAs studied thus far are converted to cap structures. ... The cap is thought to influence splicing of the first intron. ... with pre-mRNA processing.
  • ... Reactome stable identifier. ... in circularization of the mRNA to facilitate multiple rounds of translation. ... The cap is also important for mRNA ...
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Pathway: mRNA 3'-end processing  from Reactome  [60 molecules]
The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript.

Summary:  The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.

  • ... mRNA 3'-end processing ...
  • ... Reactome ...
  • ... reactome.
  • The 3' ends of eukaryotic mRNAs. ...'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester. ... be studied as an isolated event iin vitro/i, it appears to be connected to transcription, splicing.
  • Formation of mRNA 3' ends in eukaryotes: mechanism ...
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Pathway: Processing of Capped Intronless Pre-mRNA  from Reactome  [52 molecules]
Authored: Marzluff, WF, 2003-08-22 00:29:39.

Summary:  Authored: Marzluff, WF, 2003-08-22 00:29:39

  • Processing of Capped Intronless Pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • Co-transcriptional pre-mRNA splicing is not obligatory. ... Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. ... is required for efficient translation of histone mRNA in vivo and in vitro ...
  • ... Reactome stable ...
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Pathway: Post-Elongation Processing of Intronless pre-mRNA  from Reactome  [52 molecules]
  • Post-Elongation Processing of Intronless pre-mRNA ...
  • ... Reactome ...
  • ... reactome. ... pre-mRNA ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.