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Searched for: REACTOME AND mRNA 3'-end processing [All Organisms, All Data Sources]

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Pathways (77)Molecules (156)
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Pathway: mRNA 3'-end processing  from Reactome  [60 molecules]
The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript.

Summary:  The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.

  • ... mRNA 3'-end processing ...
  • ... Reactome ...
  • ... reactome.
  • The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. ... For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester. ... While 3' processing can ...
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Pathway: Inhibition of Host mRNA Processing and RNA Silencing  from Reactome  [6 molecules]
The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs.

Summary:  The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus.

  • Inhibition of Host mRNA Processing and RNA Silencing ...
  • ... Reactome ...
  • ... reactome.
  • Inhibition of Host mRNA Processing. ... specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. ... NS1 also inhibits the splicing of pre-mRNAs. ... poly(A)-binding protein II of the cellular 3'-end processing machinery ...
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Pathway: Formation and Maturation of mRNA Transcript  from Reactome  [403 molecules]
Edited: Joshi-Tope, G, 0000-00-00 00:00:00.

Summary:  Edited: Joshi-Tope, G, 0000-00-00 00:00:00

  • Formation and Maturation of mRNA Transcript ...
  • ... Reactome ...
  • ... reactome.
  • Formation and Maturation of mRNA Transcript. ..., and the generation of a 3' end, by cleavage, and except in the case of histone pre-mRNAs. ...-mRNA processing does not necessarily imply a functional coupling between the transcription and mRNA. ... In other cases a tight link exists between a particular processing reaction ...
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Pathway: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs  from Reactome  [21 molecules]
Authored: Marzluff, WF, 2003-08-22 00:29:39.

Summary:  Authored: Marzluff, WF, 2003-08-22 00:29:39

  • ... ' end processing of histone pre-mRNA in vitro.
  • SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs ...
  • ... Reactome ...
  • ... Processing of Replication-Dependent Histone Pre-mRNAs ...
  • There are two well-documented trans-acting factors required for histone pre-mRNA processing. ... protein is likely the first protein that binds to the histone pre-mRNA as it is being transcribed ...
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Pathway: Processing of Capped Intronless Pre-mRNA  from Reactome  [52 molecules]
Authored: Marzluff, WF, 2003-08-22 00:29:39.

Summary:  Authored: Marzluff, WF, 2003-08-22 00:29:39

  • ... Processing of Capped Intronless Pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • Co-transcriptional pre-mRNA splicing. ... is required for efficient translation of histone mRNA in vivo and in vitro ...
  • ... Reactome stable. ... Formation of the 3' end of histone mRNA.
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Pathway: mRNA Decay by 5' to 3' Exoribonuclease  from Reactome  [25 molecules]
Authored: May, B, 2009-07-22.

Summary:  Authored: May, B, 2009-07-22

  • ... mRNA Decay by 5' to 3' Exoribonuclease ...
  • ... Reactome ...
  • ... reactome.
  • Degradation of mRNA from 5' to 3' occurs in three steps. ... First, the mRNA is bound at its 3' end by the Lsm1-7 complex. ... Second, the 7-methylguanosine cap of the mRNA is hydrolyzed by the DCP1-DCP2 complex ...
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Pathway: Post-Elongation Processing of Intronless pre-mRNA  from Reactome  [52 molecules]
  • Post-Elongation Processing of Intronless pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Post-Elongation Processing of Intron-Containing pre-mRNA  from Reactome  [60 molecules]
  • Post-Elongation Processing of Intron-Containing pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: mRNA Processing  from Reactome  [329 molecules]
Processing of mRNA encompasses the capping of mRNA, processing of mRNAs with and without introns, and also modification of mRNA, as in mRNA editing.

Summary:  Processing of mRNA encompasses the capping of mRNA, processing of mRNAs with and without introns, and also modification of mRNA, as in mRNA editing.

  • ... mRNA Processing ...
  • ... Reactome ...
  • ... reactome.
  • ... Processing of mRNA encompasses the capping of mRNA, processing of mRNAs with and without introns, and also modification of mRNA, as in mRNA editing.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: Processing of Capped Intron-Containing Pre-mRNA  from Reactome  [254 molecules]
Authored: Carmichael, GG, Hammarskjold, ML, Hastings, M, Krainer, AR, Marzluff, WF, Wahle, E, Zhang, Z, 2003-06-05 08:30:31.

Summary:  Authored: Carmichael, GG, Hammarskjold, ML, Hastings, M, Krainer, AR, Marzluff, WF, Wahle, E, Zhang, Z, 2003-06-05 08:30:31

  • ... Processing of Capped Intron-Containing Pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • ... (nascent) mRNA transcript is mRNA Processing. ... For successful gene expression, the primary mRNA. ...-transcriptional pre-mRNA splicing is not obligatory. ... Pre-mRNA splicing begins co-transcriptionally ...