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Searched for: REACTOME AND Transcriptional Regulation of White Adipocyte Differentiation [All Organisms, All Data Sources]

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Pathway: Transcriptional Regulation of White Adipocyte Differentiation  from Reactome  [75 molecules]
Reviewed: D'Eustachio, P, 2009-05-26 22:09:50.

Summary:  Reviewed: D'Eustachio, P, 2009-05-26 22:09:50

  • ... Transcriptional Regulation of White Adipocyte Differentiation ...
  • ... Reactome ...
  • ... reactome.
  • ... of the first observable events during adipocyte differentiation is a transient increase in expression. ... substantial adipocyte differentiation in fibroblasts while CEBPD has a minimal effect.
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Pathway: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells  from Reactome  [7 molecules]
The properties of transcriptional networks in late stage (branching morphogenesis) pancreatic bud precursor cells are inferred from the properties of well-studied networks in mouse models.

Summary:  The properties of transcriptional networks in late stage (branching morphogenesis) pancreatic bud precursor cells are inferred from the properties of well-studied networks in mouse models. In mice, committed but undifferentiated epithelial cells are organized into branching ductal structures. At a molecular level, expression of Pdx1, Nkx2.2, and Nkx6.1 is reduced while Hnf6 expression remains high. Hnf6 mediates the continued expression of Onecut3 and Hnf1 beta and epithelial cell proliferation. As expression of Ngn3 (corresponds to human NEUROG3) rises, endocrine differentiation of the epithelial cells begins (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).

  • ... Transcriptional networks controlling pancreatic development and beta cell function ...
  • ... Reactome. ...Regulation< [Cont. ...] of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells ...
  • The properties of transcriptional networks in late stage (branching morphogenesis ...
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Pathway: Regulation of gene expression in early pancreatic precursor cells  from Reactome  [8 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Regulation of gene expression in early pancreatic precursor cells ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of gene. ... The properties of transcriptional networks early in the differentiation of human pancreatic cells.
  • ... Transcriptional networks controlling pancreatic development and beta cell function ...
  • ... Reactome stable identifier.
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Pathway: Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells  from Reactome  [5 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation. ... neurogenin 3 plays a central role in the induction of endocrine differentiation in the developing.
  • ... Transcriptional networks controlling pancreatic development and beta cell function ...
  • ... Reactome stable identifier.
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Pathway: Activation of the AP-1 family of transcription factors  from Reactome  [12 molecules]
Edited: Shamovsky, V, 2010-02-27.

Summary:  Edited: Shamovsky, V, 2010-02-27

  • ... Reactome ...
  • ... ) proteins, mainly of Jun-Jun, Jun-Fos or Jun-ATF. ... pAP-1 members are involved in the regulation. ..., differentiation, cell migration. ... The ability of a single transcription factor to determine a cell fate critically. ...; transcriptional, translational and post-translational control mechanisms contribute to the balanced production of AP-1 proteins and their functions. ... Briefly, regulation occurs through:ollieffects on jun ...
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Pathway: Factors involved in megakaryocyte development and platelet production  from Reactome  [124 molecules]
Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets.

Summary:  Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MK's mature, the polyploid nucleus becomes horseshoe-shaped, the cytoplasm expands, and platelet organelles and the demarcation membrane system are amplified. Proplatelet projections form which give rise to de novo circulating platelets (Deutsch & Tomer 2006).

  • ... Reactome ...
  • ... platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic. ... at several levels including proliferation, differentiation and platelet release (Kaushansky 2003.
  • ... White, G ...
  • ... Transcriptional control of megakaryocyte development ...
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Pathway: Regulation of beta-cell development  from Reactome  [125 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Regulation of beta-cell development ...
  • ... Reactome ...
  • ... reactome.
  • ... transduction pathways and transcriptional networks. ... NEUROG3 is known to activate a complex transcriptional. ... and in subsequent stages of differentiation of endocrine cells.
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Pathway: Notch-HLH transcription pathway  from Reactome  [7 molecules]
THE NOTCH-HLH TRANSCRIPTION PATHWAY:

Notch signaling was first identified in Drosophila, where it has been studied in detail at the genetic, molecular, biochemical and cellular levels (reviewed in Justice, 2002; Bray, 2006; Schweisguth, 2004; Louvri, 2006).

Summary:  THE NOTCH-HLH TRANSCRIPTION PATHWAY:

  • ... Reactome ...
  • ... reactome.
  • ... All three of the co-repressor proteins have been shown to be necessary for proper gene regulation. ... that such "general" transcriptional cofactors can have.
  • ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: Regulation of gene expression in beta cells  from Reactome  [113 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Regulation of gene expression in beta cells ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of gene expression in beta cells.
  • ... Transcriptional networks controlling pancreatic development and beta cell function ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Interleukin-3, 5 and GM-CSF signaling  from Reactome  [89 molecules]
The Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta subunit, often referred to as the common beta (Bc).

Summary:  The Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta subunit, often referred to as the common beta (Bc). Both subunits contain extracellular conserved motifs typical of the cytokine receptor superfamily. The cytoplasmic domains have limited similarity with other cytokine receptors and lack detectable catalytic domains such as tyrosine kinase domains.

  • ... Reactome ...
  • ... reactome.
  • ... is capable of inducing the growth and differentiation of multi-potential hematopoietic stem cells. ... growth factor responsible for the maturation and differentiation of eosinophils. ... It was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation. ... differentiation, synergises with Epo in the proliferation of erythroid and megakaryocytic progenitor cells ...