This portal has not been updated since October 2011. Please use the new PC2 web services.
Send us your feedback.  Sign up for Pathway Commons announcements.  RSS Logo RSS Feed

Searched for: REACTOME AND Transcription of the HIV genome [All Organisms, All Data Sources]

Your search has found 153 relevant records:

Narrow Results:

Pathways (153)Molecules (41)
Showing Results 1 - 10 of 153  | Next 10
0%0%
Pathway: Uncoating of the HIV Virion  from Reactome  [21 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Uncoating of the HIV Virion ...
  • ... Reactome ...
  • ... reactome.
  • ... Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane ...
0%0%
Pathway: Transcription of the HIV genome  from Reactome  [174 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • ... Transcription of the HIV genome ...
  • ... Reactome ...
  • ... reactome.
  • ... cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. ... sequences that recruit cellular transcription factors. ... The U3 region of the 5' LTR contains numerous cis-acting elements that regulate Pol II-mediated transcription initiation. ... The full-length transcript ...
0%0%
Pathway: Integration of viral DNA into host genomic DNA  from Reactome  [25 molecules]
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22.

Summary:  Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

  • ... the chromosomal level, HIV has been found to favor active transcription units for integration. ...Integration of viral DNA into host genomic DNA ...
  • ... Reactome ...
  • ... reactome. ... PSIP1/LEDGF/p75 binds tightly to HIV integrase, and also to chromatin. ... integration in transcription units. ... Thus PSIP1/LEDGF/p75 has been hypothesized to act as a tethering factor that dictates at least in part the placement of HIV integration sites. ... pThe integration target DNA ...
0%0%
Pathway: APOBEC3G mediated resistance to HIV-1 infection  from Reactome  [33 molecules]
Reviewed: Simon, V, 2007-01-30 23:07:12.

Summary:  Reviewed: Simon, V, 2007-01-30 23:07:12

  • ... for minus-strand deamination of the HIV genome ...
  • ... Reactome ...
  • ... reactome. ... of Vif deficient HIV-1 (Sheehy 2002). ... It is expressed in cell populations that are susceptible to HIV. ... intermediate during reverse transcription. ... Deamination results in the induction of G-to-A hypermutations. ... by the viral Vif protein ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page ...
0%0%
Pathway: Reverse Transcription of HIV RNA  from Reactome  [39 molecules]
The RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromosome and transcribed to yield both viral mRNAs and viral genomic RNAs.

Summary:  The RNA genome of HIV-1, like that of other retroviruses, is reverse-transcribed (Baltimore 1970; Temin and Mizutani 1970) into double-stranded DNA, which is then integrated into a host cell chromosome and transcribed to yield both viral mRNAs and viral genomic RNAs. HIV-1 reverse transcription takes place in the cytosol of a newly infected host cell and involves multiple steps of RNA synthesis and degradation of the RNA strand of RNA:DNA duplexes mediated by the HIV-1 RT protein, as well as two template switches, to yield a DNA duplex colinear with the viral genomic RNA but with additional Long Terminal Repeat (LTR) sequence motifs at both ends (Telesnitsky and Goff 1997; Jonckheere et al. 2000).

  • Reverse Transcription of HIV RNA ...
  • ... Reactome ...
  • ... reactome.
  • The RNA genome. ... HIV-1 reverse transcription takes place. ... two catalytic activities essential for transcription of a DNA duplex copy of the viral genomic RNA. ...pThe process of reverse transcription is outlined in the figure below: viral genomic RNA ...
0%0%
Pathway: Late Phase of HIV Life Cycle  from Reactome  [232 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • Late Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • ... of the HIV gene products and the assembly of viral particles. ... The assembly of viral particles will be covered in a later release of Reactome. ... HIV-1 gene expression is regulated by both cellular and viral proteins. ... Although the initial activation of the HIV-1 transcription is facilitated by cellular ...
0%0%
Pathway: HIV-1 Transcription Elongation  from Reactome  [87 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • HIV-1 Transcription Elongation ...
  • ... Reactome ...
  • ... reactome.
  • Edited: Matthews, L. ... of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al. ... While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation ...
0%0%
Pathway: Global Genomic NER (GG-NER)  from Reactome  [70 molecules]
GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.

Summary:  GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.

  • ... to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non.
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
  • ... Use this URL to connect to the web page ...
0%0%
Pathway: Plus-strand DNA synthesis  from Reactome  [24 molecules]
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22.

Summary:  Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

  • ... Reactome ...
  • ... reactome.
  • ... duplex DNA corresponding to the full length of the HIV genomic RNA with long terminal repeat (LTR.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
  • Goff, SP ...
  • Retroviruses (Coffin, JM ...
0%0%
Pathway: Transcription from mitochondrial promoters  from Reactome  [10 molecules]
Authored: Gustafsson, C, 2005-04-25 22:00:00.

Summary:  Authored: Gustafsson, C, 2005-04-25 22:00:00

  • ... Transcription from mitochondrial promoters ...
  • ... Reactome ...
  • ... reactome.
  • ... Transcription from mitochondrial promoters 271828. ... in the respiratory chain of human mitochondria are encoded by the mitochondrial genome (mtDNA. ... The double-stranded mitochondrial genome lacks introns and the longer non-coding region contains the control elements for transcription and replication of mtDNA ...