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Searched for: REACTOME AND Telomere C-strand synthesis initiation [All Organisms, All Data Sources]

Your search has found 9 relevant records:

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Pathways (9)Molecules (23)
Showing Results 1 - 9 of 9 
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Pathway: Telomere C-strand synthesis initiation  from Reactome  [20 molecules]
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis.

Summary:  DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. There have been reports that TRF1 inhibits this activity at telomeres, though the mechanism and physiological relevance of this inhibition remain to be elucidated.

  • ... Telomere C-strand synthesis initiation ...
  • ... Reactome ...
  • ... reactome.
  • DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis.
  • TRF1 inhibits telomere C-strand DNA ...
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Pathway: Processive synthesis on the C-strand of the telomere  from Reactome  [39 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • Processive synthesis on the C-strand of the telomere ...
  • ... Reactome ...
  • ... reactome.
  • ... and lagging strand synthesis.
  • ... Reactome stable identifier. ... the processive synthesis of a short run of DNA called an Okazaki fragment begins. ... DNA synthesis ...
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Pathway: Polymerase switching on the C-strand of the telomere  from Reactome  [29 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • Polymerase switching on the C-strand of the telomere ...
  • ... Reactome ...
  • ... reactome.
  • ... initiation of leading and lagging strand synthesis.
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Pathway: Telomere C-strand (Lagging Strand) Synthesis  from Reactome  [63 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • ... Telomere C-strand (Lagging Strand) Synthesis ...
  • ... Reactome ...
  • ... reactome.
  • ... Strand-displacement synthesis.
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Pathway: Packaging Of Telomere Ends  from Reactome  [19 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • Packaging Of Telomere Ends ...
  • ... Reactome ...
  • ... reactome.
  • Multiple steps, including C-strand resection, telomerase-mediated elongation, and C-strand synthesis are involved in processing and maintaining the telomere.
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Pathway: Telomere Maintenance  from Reactome  [94 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • ... activities, including C-strand synthesis, which fills in the opposing strand, and nucleolytic. ... G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere. ...Telomere Maintenance ...
  • Maintenance of Telomeres ...
  • ... Reactome ...
  • ... reactome. ... owing to the "end-replication problem", a consequence of the mechanism of lagging-strand synthesis. ... of Tetrahymena telomerase required for telomere repeat synthesis ...
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Pathway: Telomere Extension By Telomerase  from Reactome  [20 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • ... Telomere Extension By Telomerase ...
  • ... Reactome ...
  • ... reactome.
  • ... of nucleotides to the telomere end. ... After synthesis of a repeat is completed, relative movement. ..., like most eukaryotic organisms, add direct repeats to the telomere using a specialized DNA polymerase.
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Pathway: Chromosome Maintenance  from Reactome  [125 molecules]
Chromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells.

Summary:  Chromosome maintenance is critical for stable chromosome function in mammalian and other eukaryotic cells. Aspects of telomere maintenance and nucleosome assembly are covered here.

  • ... Reactome ...
  • ... reactome.
  • ... Aspects of telomere maintenance.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Nonsense Mediated Decay Enhanced by the Exon Junction Complex  from Reactome  [133 molecules]
Edited: May, B, 2010-10-08.

Summary:  Edited: May, B, 2010-10-08

  • ... Reactome ...
  • ... plays roles in Staufen-mediated decay, histone mRNA decay, telomere maintenance, genome integrity.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...