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Searched for: REACTOME AND Synthesis of DNA [All Organisms, All Data Sources]

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Pathway: Synthesis of DNA  from Reactome  [184 molecules]
The actual synthesis of DNA occurs in the S phase of the cell cycle.

Summary:  The actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of the primer. The DNA replication preinitiation events begin in late M or early G1 phase.

  • ... Synthesis of DNA ...
  • ... Reactome ...
  • ... reactome.
  • The actual synthesis of DNA occurs in the S phase of the cell cycle. ... This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of the primer. ... The DNA replication preinitiation events begin in late M or early G1 phase.
  • ... Reactome stable identifier.
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Pathway: Repair synthesis of patch ~27-30 bases long by DNA polymerase  from Reactome  [34 molecules]
Repair synthesis is carried out by the DNA dependent DNA polymerases, delta and epsilon.

Summary:  Repair synthesis is carried out by the DNA dependent DNA polymerases, delta and epsilon.

  • Repair synthesis of patch ~27-30 bases long by DNA polymerase ...
  • ... Reactome ...
  • ... reactome.
  • Repair synthesis is carried out by the DNA dependent DNA. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: Telomere C-strand synthesis initiation  from Reactome  [20 molecules]
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis.

Summary:  DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. There have been reports that TRF1 inhibits this activity at telomeres, though the mechanism and physiological relevance of this inhibition remain to be elucidated.

  • Telomere C-strand synthesis initiation ...
  • ... Reactome ...
  • ... reactome.
  • ... DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. ... with immunoaffinity-purified DNA polymerase-alpha.
  • ... Reactome stable identifier.
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Pathway: Gap-filling DNA repair synthesis and ligation in TC-NER  from Reactome  [41 molecules]
Authored: Gopinathrao, G, 2004-02-11 18:33:11.

Summary:  Authored: Gopinathrao, G, 2004-02-11 18:33:11

  • Gap-filling DNA repair synthesis and ligation in TC-NER ...
  • ... Reactome ...
  • ... reactome.
  • Gap-filling DNA repair synthesis. ... is carried out by DNA polymerases, delta and epsilon.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Gap-filling DNA repair synthesis and ligation in GG-NER  from Reactome  [40 molecules]
The resultant gap is filled by polymerase activities of Pol delta and Pol epsilon.

Summary:  The resultant gap is filled by polymerase activities of Pol delta and Pol epsilon. Accessory replication protein complexes of RPA, PCNA and RFC play a role in this synthesis. DNA Ligase 1 seals the gap restoring the covalent integrity of the repaired strand.

  • Gap-filling DNA repair synthesis and ligation in GG-NER ...
  • ... Reactome ...
  • ... reactome.
  • Gap-filling DNA repair synthesis. ... Accessory replication protein complexes of RPA, PCNA and RFC play a role in this synthesis. ... DNA Ligase 1 seals the gap restoring the covalent integrity of the repaired strand.
  • Which DNA polymerases are used for DNA-repair in eukaryotes? ...
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Pathway: Translesion synthesis by DNA polymerases bypassing lesion on DNA template  from Reactome  [15 molecules]
Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carcinogenesis and/or cell death.

Summary:  Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carcinogenesis and/or cell death. While cells posses repair mechanisms like nucleotide excision and base excision repair pathways to maintain the integrity of the genome, not all lesions on the genome can be repaired efficiently by these processes in time for DNA replication, and some types of lesion are repaired very inefficiently. To prevent acute cell death through arrested DNA replication at unrepaired lesions, cells have a mechanism, referred to as translesion synthesis, which allows DNA synthesis to proceed past lesions (Masutani et al., 2000).

  • Translesion synthesis by DNA polymerases bypassing lesion on DNA template ...
  • ... Reactome 271828. ... synthesis by DNA polymerases bypassing lesion on DNA template ...
  • Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA. ..., referred to as translesion synthesis, which allows DNA synthesis to proceed past lesions (Masutani et. ... by these processes in time for DNA replication, and some types of lesion are repaired very inefficiently.
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Pathway: Repair synthesis for gap-filling by DNA polymerase in TC-NER  from Reactome  [35 molecules]
  • Repair synthesis for gap-filling by DNA polymerase in TC-NER ...
  • ... Reactome ...
  • ... reactome.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: DNA replication initiation  from Reactome  [25 molecules]
DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis.

Summary:  DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984).

  • ... DNA replication initiation ...
  • ... Reactome ...
  • ... reactome.
  • ... DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. ... In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. ... First, the DNA primase portion of this complex synthesizes approximately 6-10 ...
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Pathway: Plus-strand DNA synthesis  from Reactome  [24 molecules]
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22.

Summary:  Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

  • Plus-strand DNA synthesis ...
  • ... Reactome ...
  • ... reactome.
  • ... sequence (3' PPT), are spared from degradation during minus strand DNA synthesis and prime plus-strand synthesis. ... At least two discrete steps of DNA replication, removal of the PPT RNAs and the tRNA. ... Both DNA synthesis and RNA degradation are catalyzed by domains of the HIV-1 ...
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Pathway: Processive synthesis on the lagging strand  from Reactome  [55 molecules]
The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand.

Summary:  The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.

  • Processive synthesis on the lagging strand ...
  • ... Reactome ...
  • ... reactome.
  • The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. ... However, the processive synthesis on the lagging strand proceeds very differently. ... DNA synthesis is discontinuous, and involves the formation ...