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Searched for: REACTOME AND Switching of origins to a post-replicative state [All Organisms, All Data Sources]

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Pathways (10)
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Pathway: Switching of origins to a post-replicative state  from Reactome  [103 molecules]
  • ... Switching of origins to a post-replicative state ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • Database identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page ...
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Pathway: Polymerase switching  from Reactome  [29 molecules]
After the primers are synthesized, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching.

Summary:  After the primers are synthesized, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA.

  • Polymerase switching ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • After the primers are synthesized, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. ... this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • ... REACTOME DATABASE ID ...
  • Stillman, B ...
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Pathway: Polymerase switching on the C-strand of the telomere  from Reactome  [29 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • Polymerase switching on the C-strand of the telomere ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • Polymerase switching on the C-strand. ... Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. ... required for SV40 DNA replication in vitro. ... Switching of DNA polymerase alpha and delta during. ... to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
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Pathway: Removal of the Flap Intermediate from the C-strand  from Reactome  [27 molecules]
Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991).

Summary:  Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap.

  • ... Reactome ...
  • ... reactome. ... Replication Protein A regulates the switching of endonucleases during the removal of the displaced. ... Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
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Pathway: Processive synthesis on the lagging strand  from Reactome  [55 molecules]
The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand.

Summary:  The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.

  • ... Reactome ...
  • ... reactome. ... The key event that allows the processive synthesis on the lagging strand, is polymerase switching. ... replication in vitro. ... Switching of DNA polymerase alpha and delta during initiation of leading. ... of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: Processive synthesis on the C-strand of the telomere  from Reactome  [39 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • ... Reactome ...
  • ... reactome.
  • Once polymerase switching from pol alpha to pol delta is complete. ... DNA replication in vitro. ... Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
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Pathway: Telomere C-strand (Lagging Strand) Synthesis  from Reactome  [63 molecules]
Reviewed: Price, C, 2006-07-13 18:33:38.

Summary:  Reviewed: Price, C, 2006-07-13 18:33:38

  • ... Reactome ...
  • ... reactome. ... the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive. ... in Reactome: http://www. ...reactome [Cont. ...]
  • ... REACTOME DATABASE ID ...
  • GO biological process ...
  • GENE_ONTOLOGY ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance ...
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Pathway: Removal of the Flap Intermediate  from Reactome  [44 molecules]
Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991).

Summary:  Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap.

  • ... Reactome ...
  • ... reactome.
  • Homo sapiens. ... the switching of endonucleases during the removal of the displaced flap.
  • Database identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • ... REACTOME DATABASE ID ...
  • ... for nucleotide excision repair.
  • ... Reactome stable identifier. ... Use this URL to connect ...
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Pathway: Lagging Strand Synthesis  from Reactome  [65 molecules]
Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously.

Summary:  Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously. This strand is called the lagging strand. Although the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive synthesis on the two strands proceeds quite differently. Short DNA fragments, about 100 bases long, called Okazaki fragments are synthesized on the RNA-DNA primers first. Strand-displacement synthesis occurs, whereby the primer-containing 5'-terminus of the adjacent Okazaki fragment is folded into a single-stranded flap structure. This flap structure is removed by endonucleases, and the adjacent Okazaki fragments are joined by DNA ligase.

  • ... Reactome ...
  • ... reactome.
  • Homo sapiens 271828. ... is called the lagging strand. ... Although the polymerase switching on the lagging strand is very.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • REACT_312 ...
  • ... REACTOME ...
  • Database identifier. ... Use this URL to connect to the web page of this instance ...
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Pathway: Activation of BAD and translocation to mitochondria  from Reactome  [11 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • ... Reactome ...
  • ... reactome.
  • The switching on/off of its phosphorylation by growth/survival factors regulates. ... Calcineurin activates BAD by dephosphorylation.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome [Cont. ...]
  • REACT_549 ...
  • ... REACTOME ...
  • Adams, JM ...