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Searched for: REACTOME AND Signaling by Robo receptor [All Organisms, All Data Sources]

Your search has found 224 relevant records:

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Pathways (224)Molecules (4)
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Pathway: Signaling by Robo receptor  from Reactome  [44 molecules]
Authored: Garapati, P V, 2008-09-05 06:02:05.

Summary:  Authored: Garapati, P V, 2008-09-05 06:02:05

  • ... Signaling by Robo receptor ...
  • ... Reactome ...
  • ... reactome.
  • The Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. ... The major function of the Robo receptors is to mediate repulsion of the navigating growth cones. ... There are four human Robo homologues, Robo1, Robo2, Robo3 and Robo4.
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Pathway: Role of Abl in Robo-Slit signaling  from Reactome  [17 molecules]
Authored: Garapati, P V, 2008-09-05 06:02:05.

Summary:  Authored: Garapati, P V, 2008-09-05 06:02:05

  • Role of Abl in Robo-Slit signaling ...
  • ... Reactome ...
  • ... reactome.
  • Abl plays a dual role in the Robo pathway. ... As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed back on the receptor (by down regulating through phosphorylation) to adjust ...
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Pathway: DAG and IP3 signaling  from Reactome  [43 molecules]
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07.

Summary:  Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07

  • DAG and IP3 signaling ...
  • ... Reactome ...
  • ... reactome.
  • Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling ...
  • ... hydrolysis of PIP2 and the subsequent downstream signaling events.
  • ... in Reactome: http://www. ...reactome.
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Pathway: Signaling by NODAL  from Reactome  [42 molecules]
Edited: May, B, 2011-01-23.

Summary:  Edited: May, B, 2011-01-23

  • ... Signaling by NODAL ...
  • ... Reactome ...
  • ... reactome.
  • ... Signaling by NODAL is essential. ... negatively regulate NODAL signaling. ... NODAL dimers bind the NODAL receptor comprising a type I Activin receptor (ACVR1B or ACVR1C ...
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Pathway: Signaling by Insulin receptor  from Reactome  [145 molecules]
Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.

Summary:  Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor tyrosine kinase. This allows association of IRSs with downstream effectors such as PI-3K via its Src homology 2 (SH2) domains leading to end point events such as Glut4 translocation. Shc when tyrosine phosphorylated associates with Grb2 and can thus activate the Ras/MAPK pathway independent of the IRSs.

  • ... Signaling by Insulin receptor ...
  • Insulin receptor mediated signaling ...
  • ... Reactome ...
  • ... reactome.
  • Insulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e. ... IRS and Shc) by the insulin receptor tyrosine kinase.
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Pathway: Signaling by EGFR  from Reactome  [216 molecules]
Reviewed: Muthuswamy, S, Heldin, CH, 2008-02-28 15:20:51.

Summary:  Reviewed: Muthuswamy, S, Heldin, CH, 2008-02-28 15:20:51

  • ... Signaling by EGFR ...
  • Epidermal Growth Factor Receptor (EGFR) signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... Signaling by EGFR. ... receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor. ... the dimerization interface in the extracellular domain of EGFR, leading to receptor homo- or heterodimerization. ... on tyrosine residues in the cytoplasmic tail of the receptor.
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Pathway: GPCR downstream signaling  from Reactome  [151 molecules]
Reviewed: Akkerman, JW, 2009-06-03.

Summary:  Reviewed: Akkerman, JW, 2009-06-03

  • GPCR downstream signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... Rich tapestry of G protein-coupled receptor signaling and regulatory mechanisms ...
  • ... betagamma subunits: central mediators of G protein-coupled receptor signaling ...
  • ... -coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream ...
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Pathway: Tie2 Signaling  from Reactome  [35 molecules]
The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage.

Summary:  The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.

  • Tie2 Signaling ...
  • ... Reactome ...
  • ... reactome.
  • The Tie2/Tek receptor tyrosine kinase plays a pivotal. ... and Tie signaling pathways in vascular development ...
  • ... Reactome stable identifier. ... for various signaling proteins involved in different signal transduction cascades that can effect survival. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: PIP3 activates AKT signaling  from Reactome  [47 molecules]
Signaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs).

Summary:  Signaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PIK3), PI3KR1 (also known as PI3K p85), either directly or indirectly, through adaptor proteins. The RTK-associated PI3KR1 recruits the 110 kDa catalytic subunit of PI3K, PI3KCA (also known as PI3K p110), resulting in the assembly of an active PI3K complex. Active PI3K phosphorylates PIP2, converting it to PIP3. PIP3 formation is negatively regulated by the PTEN tumor suppressor protein, a phosphatase that dephosphorylates PIP3 and coverts it to PIP2. PIP3 recruits AKT and PDK1 to the plasma membrane, enabling the PDK1 to phosphorylate AKT on a conserved threonine residue. AKT is also phosphorylated on a conserved serine residue by the TORC2 complex (also activated as a consequence of RTK signaling). Both the threonine and the serine residue need to be phosphorylated in order for the AKT to become fully active. The active AKT dissociates from the PIP3, and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.

  • PIP3 activates AKT signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... Signaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). ... residue by the TORC2 complex (also activated as a consequence of RTK signaling). ... For a recent review of AKT signaling, please ...
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Pathway: TRAIL signaling  from Reactome  [11 molecules]
Authored: Gillespie, ME, 2004-08-31 03:31:31.

Summary:  Authored: Gillespie, ME, 2004-08-31 03:31:31

  • TRAIL signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... death domain (DD), encoded within the cytoplasmic domain of the receptor. ... TRAIL and apoptosis induction by TNF-family death receptors ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.