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Searched for: REACTOME AND Regulation of mRNA Stability by Proteins that Bind AU-rich Elements [All Organisms, All Data Sources]

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Pathways (219)Molecules (5)
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Pathway: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements  from Reactome  [142 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... Regulation of mRNA Stability by Proteins that Bind AU-rich Elements ...
  • ... Reactome ...
  • ... Stability by Proteins that Bind AU-rich Elements ...
  • RNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target.
  • ... AU-rich elements. ... elements and the control of gene expression through regulated mRNA stability ...
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Pathway: Stabilization of mRNA by HuR  from Reactome  [19 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... ) is a ubiquitous protein that binds AU-rich elements in mRNAs and acts to stabilize the mRNAs.
  • ... AU-rich elements and associated factors: are there unifying principles? 271828. ...Stabilization of mRNA by HuR ...
  • ... Reactome ...
  • ... reactome.
  • ... modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II.
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Pathway: Destabilization of mRNA by Tristetraprolin (TTP)  from Reactome  [26 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... by phosphorylated TTP. ... Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor.
  • ... AU-rich elements and associated factors: are there unifying principles? ...
  • Destabilization of mRNA by Tristetraprolin (TTP) ...
  • ... Reactome ...
  • ... reactome. ...-rich elements and recruits enzymes that degrade RNA.
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Pathway: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)  from Reactome  [34 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... (BRF1, ZFP36L1, not to be confused with transcription factor IIIB) binds AU-rich elements in the 3. ... AU-rich elements and associated factors: are there unifying principles? ...
  • Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) ...
  • ... Reactome ...
  • ... Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins.
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Pathway: Destabilization of mRNA by AUF1 (hnRNP D0)  from Reactome  [78 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • AUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3.
  • ... Regulation of A + U-rich element-directed mRNA turnover.
  • ... AU-rich elements and associated factors. ..., functions in AU-rich element-mediated mRNA decay ...
  • Destabilization of mRNA by AUF1 (hnRNP D0) ...
  • ... Reactome ...
  • ... reactome.
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Pathway: Destabilization of mRNA by KSRP  from Reactome  [28 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... AU-rich elements and associated factors. ...Destabilization of mRNA by KSRP ...
  • ... Reactome ...
  • ... reactome.
  • Destabilization of mRNA by KSRP ...
  • KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs.
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Pathway: 3' -UTR-mediated translational regulation  from Reactome  [124 molecules]
Authored: Matthews, L, 2004-12-20 12:26:45.

Summary:  Authored: Matthews, L, 2004-12-20 12:26:45

  • ... 3' -UTR-mediated translational regulation ...
  • ... Reactome ...
  • ... reactome.
  • ... 3' -UTR-mediated translational regulation 271828. ... regions (UTRs) of mRNA and RNA-binding proteins. ... One such mechanism requires circularization of the mRNA molecule involving protein-protein interactions between the mRNA termini (Mazumder et al. ... requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein ...
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Pathway: Transport of Mature Transcript to Cytoplasm  from Reactome  [98 molecules]
Transport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets.

Summary:  Transport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this transport provide spatial and temporal control over mRNA expression and ultimately control over translation. It should be noted that mRNA export does not rely on a specific motif in the mRNA molecule, but rather transport appears to be coupled to processing and regulation. The specific proteins that are bound to the mRNA determine when it will be transported to the cytoplasm. This limitation insures that transport overwhelmingly favors transport of fully processed mRNA molecules.

  • ... , but rather transport appears to be coupled to processing and regulation. ... The specific proteins. ...Transport of Mature Transcript to Cytoplasm ...
  • ... Reactome ...
  • ... reactome.
  • Transport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. ... The separation of the two compartments and the regulation of this transport provide spatial and temporal control over mRNA expression and ultimately control over ...
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Pathway: Dissolution of Fibrin Clot  from Reactome  [31 molecules]
Edited: D'Eustachio, P, 0000-00-00 00:00:00.

Summary:  Edited: D'Eustachio, P, 0000-00-00 00:00:00

  • ... and plasmin itself are inactivated by specific serpins, proteins that bind to serine proteases to form. ...Dissolution of Fibrin Clot ...
  • ... Reactome ...
  • ... reactome.
  • ... and fibrinolysis occur only in complexes formed at the clot surface or on a cell membrane - proteins free.
  • ... Elements of the fibrinolytic system ...
  • ... Reactome stable identifier.
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Pathway: Activation of the AP-1 family of transcription factors  from Reactome  [12 molecules]
Edited: Shamovsky, V, 2010-02-27.

Summary:  Edited: Shamovsky, V, 2010-02-27

  • ... ) proteins, mainly of Jun-Jun, Jun-Fos or Jun-ATF. ... pAP-1 members are involved in the regulation. ... production of AP-1 proteins and their functions. ... Briefly, regulation occurs through:ollieffects on jun. ... Translational regulation mechanisms of AP-1 proteins ...
  • ... Reactome ...
  • ... referring to a group of transcription factors that bind to promoters of target genes in a sequence ...