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Searched for: REACTOME AND Regulation of Glucokinase by Glucokinase Regulatory Protein [All Organisms, All Data Sources]

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Pathways (219)Molecules (5)
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Pathway: Regulation of Glucokinase by Glucokinase Regulatory Protein  from Reactome  [40 molecules]
Glucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex.

Summary:  Glucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and sorbitol 6-phosphate (hence high concentrations of these molecules tend to reduce GCK1 activity) and inhibited by fructose 1-phosphate (hence a high concentration of this molecule tends to increase GCK1 activity). Once formed, the complex is translocated to the nucleus. In the presence of high glucose concentrations, the nuclear GCK1:GKRP complex dissociates, freeing GCK1 to return to the cytosol. The free GKRP is thought also to return to the cytosol under these conditions, but this return has not been confirmed experimentally. Possible physiological roles for this sequestration process are to decrease futile cycling between glucose and glucose 6 phosphate in hepatocytes under low-glucose conditions, and to decrease the lag between a rise in intracellular glucose levels and the onset of glucose phosphorylation in both hepatocytes and pancreatic beta cells (Brocklehurst et al. 2004; Shiota et al. 1999).

  • ... Regulation of Glucokinase by Glucokinase Regulatory Protein ...
  • ... Reactome ...
  • ... reactome.
  • ... Glucokinase (GCK1) is negatively regulated by glucokinase. ... glucokinase regulatory protein ...
  • ... Reactome stable identifier. ... glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence ...
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Pathway: Unfolded Protein Response  from Reactome  [39 molecules]
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31.

Summary:  Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

  • ... down-regulation of protein synthesis. ... These three regulatory pathways are annotated here. ...Unfolded Protein Response ...
  • ... Reactome ...
  • ... reactome.
  • Unfolded Protein Response ...
  • ... The Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. ... The UPR is provoked by the accumulation of improperly folded protein in the ER during ...
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Pathway: Regulation of ornithine decarboxylase (ODC)  from Reactome  [74 molecules]
Reviewed: D'Eustachio, P, 2008-06-12 17:57:32.

Summary:  Reviewed: D'Eustachio, P, 2008-06-12 17:57:32

  • ... Regulation of ornithine decarboxylase (ODC) ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of ornithine decarboxylase (ODC. ... Antizyme production is reduced, completing the regulatory circuit (Coffino. ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Integration of energy metabolism  from Reactome  [189 molecules]
Authored: Gopinathrao, G, D'Eustachio, P, 2005-05-11 18:49:22.

Summary:  Authored: Gopinathrao, G, D'Eustachio, P, 2005-05-11 18:49:22

  • Glucagon and regulation of glucose metabolism ...
  • ... Reactome. ...Integration of energy metabolism ...
  • ... Reactome ...
  • ... reactome.
  • ... Many hormones that affect individual physiological processes including the regulation of appetite. ...-driven regulatory pathways enable the body to sense and respond to changed amounts of nutrients. ... The binding of glucagon to its receptor results in increased cAMP synthesis, and Protein Kinase ...
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Pathway: Signal regulatory protein (SIRP) family interactions  from Reactome  [24 molecules]
Edited: Garapati, P V, 2009-02-12 18:17:40.

Summary:  Edited: Garapati, P V, 2009-02-12 18:17:40

  • Signal regulatory protein (SIRP) family interactions ...
  • ... Reactome ...
  • ... reactome.
  • Signal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly.
  • Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates ...
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Pathway: ERKs are inactivated  from Reactome  [9 molecules]
MAP Kinases are inactivated by a family of protein named MAP Kinase Phosphatases (MKPs).

Summary:  MAP Kinases are inactivated by a family of protein named MAP Kinase Phosphatases (MKPs). They act through dephosphorylation of threonine and/or tyrosine residues within the signature sequence -pTXpY- located in the activation loop of MAP kinases (pT=phosphothreonine and pY=phosphotyrosine). MKPs are divided into three major categories depending on their preference for dephosphorylating; tyrosine, serine/threonine and both the tyrosine and threonine (dual specificity phoshatases or DUSPs). The tyrosine-specific MKPs include PTP-SL, STEP and HePTP, serine/threonine-specific MKPs are PP2A and PP2C, and many DUSPs acting on MAPKs are known. Activated MAP kinases trigger activation of transcription of MKP genes. Therefore, MKPs provide a negative feedback regulatory mechanism on MAPK signaling, by inactivating MAPKs via dephosphorylation, in the cytoplasm and the nucleus. Some MKPs are more specific for ERKs, others for JNK or p38MAPK.

  • ... Reactome ...
  • ... reactome.
  • ... of protein named MAP Kinase Phosphatases (MKPs). ... They act through dephosphorylation of threonine. ... a negative feedback regulatory mechanism on MAPK signaling, by inactivating MAPKs via.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  from Reactome  [23 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • ... activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein.
  • ... Reactome ...
  • ... I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005.
  • ... Regulation of the type I IFN induction: a current view ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: EGFR downregulation  from Reactome  [63 molecules]
Reviewed: Heldin, CH, 2008-02-12 09:44:02.

Summary:  Reviewed: Heldin, CH, 2008-02-12 09:44:02

  • ... adaptations to regulate protein tyrosine kinases ...
  • ... Reactome stable identifier. ...EGFR downregulation ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all. ... and mediating their down-regulation, thus providing a means by which signaling processes can be negatively. ... protein, CIN85 (Cbl-interacting protein of 85kDa).
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Pathway: eNOS activation  from Reactome  [42 molecules]
eNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localization.

Summary:  eNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localization.

  • ... the protein-protein< [Cont. ...] interactions with associated scaffolding and regulatory proteins.
  • ... Reactome ...
  • ... reactome.
  • ... activates both Akt and the AMP-activated protein kinase (AMPK); estrogen and VEGF mainly phosphorylate eNOS. ... involved in the regulation of the endothelial nitric oxide synthase ...
  • Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 ...
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Pathway: Regulation of gene expression in beta cells  from Reactome  [113 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Regulation of gene expression in beta cells ...
  • ... Reactome ...
  • ... reactome.
  • ... Regulation of gene expression in beta cells. ... Targets of these regulatory molecules include genes encoding insulin, the GLUT2.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.