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Searched for: REACTOME AND RNA Polymerase II Promoter Escape [All Organisms, All Data Sources]

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Pathways (136)Molecules (102)
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Pathway: RNA Polymerase II HIV-1 Promoter Escape  from Reactome  [73 molecules]
RNA Polymerase II promoter escape occurs after the first phosphodiester bond has been created.

Summary:  RNA Polymerase II promoter escape occurs after the first phosphodiester bond has been created.

  • ... RNA Polymerase II HIV-1 Promoter Escape ...
  • ... Reactome ...
  • ... reactome.
  • ... RNA Polymerase II promoter escape occurs after the first phosphodiester bond has been created.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: RNA Polymerase II Promoter Escape  from Reactome  [61 molecules]
Authored: Timmers, H.

Summary:  Authored: Timmers, H. T. M., 2003-09-11 07:42:30

  • ... RNA Polymerase II Promoter Escape ...
  • ... Reactome ...
  • ... reactome.
  • ... RNA Polymerase II promoter escape occurs after the first.
  • Three transitions in the RNA polymerase II transcription complex during initiation.
  • ... Reactome stable identifier.
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Pathway: RNA Polymerase I Promoter Escape  from Reactome  [32 molecules]
Edited: Gillespie, ME, 0000-00-00 00:00:00.

Summary:  Edited: Gillespie, ME, 0000-00-00 00:00:00

  • ... RNA Polymerase I Promoter Escape ...
  • ... Reactome ...
  • ... reactome.
  • As the active RNA Polymerase I complex leaves the promoter Rrn3 dissociates from the complex. ... RNA polymerase I Promoter. ... in Reactome: http://www. ...reactome.
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Pathway: RNA Polymerase I Promoter Clearance  from Reactome  [51 molecules]
Edited: Gillespie, ME, 0000-00-00 00:00:00.

Summary:  Edited: Gillespie, ME, 0000-00-00 00:00:00

  • ... RNA Polymerase I Promoter Clearance ...
  • ... Reactome ...
  • ... reactome.
  • ... Promoter clearance is one of the rate-limiting steps in Polymerase I transcription. ... This step is composed of three phases, promoter opening, transcription initiation and promoter escape.
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Pathway: RNA Polymerase II Transcription Initiation  from Reactome  [58 molecules]
Authored: Timmers, H.

Summary:  Authored: Timmers, H. T. M., 2003-09-11 07:42:30

  • ... of a four-nucleotide RNA commits RNA polymerase II to promoter escape.
  • ... Reactome. ...RNA Polymerase II Transcription Initiation ...
  • ... Reactome ...
  • ... reactome.
  • ... RNA Polymerase II Transcription Initiation 271828.
  • Opening of an RNA polymerase II promoter occurs in two distinct steps. ... the template strand to the catalytic center of the RNA polymerase II enzyme.
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Pathway: RNA Polymerase II Transcription Initiation And Promoter Clearance  from Reactome  [76 molecules]
  • ... RNA Polymerase II Transcription Initiation And Promoter Clearance ...
  • ... Reactome ...
  • ... reactome.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  from Reactome  [53 molecules]
Formation of the pre-initiation complex.

Summary:  Formation of the pre-initiation complex

  • ... RNA Polymerase II Transcription Pre-Initiation And Promoter Opening ...
  • ... Reactome ...
  • ... reactome.
  • The general transcription factors of RNA polymerase II.
  • ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: RNA Pol II CTD phosphorylation and interaction with CE  from Reactome  [40 molecules]
To facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II.

Summary:  To facilitate co-transcriptional capping, and thereby restrict the cap structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. The C-terminal domain of the largest Pol II subunit contains several phosphorylation sites on its heptapeptide repeats. The capping enzyme guanylyltransferase and the methyltransferase bind specifically to CTD phosphorylated at Serine 5 within the CTD. Kinase subunit of TFIIH, Cdk7, catalyzes this phosphorylation event that occurs near the promoter. In addition, it has been shown that binding of capping enzyme to the Serine-5 phosphorylated CTD stimulates guanylyltransferase activity in vitro.

  • ... RNA Pol II CTD phosphorylation and interaction with CE ...
  • ... Reactome ...
  • ... reactome.
  • ... RNA Pol II CTD phosphorylation. ... structure to RNAs made by RNA polymerase II, the capping enzymes bind directly to the RNA polymerase II. ... The C-terminal domain of the largest Pol II subunit contains several phosphorylation sites on its. ... this phosphorylation event that occurs near the promoter.
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Pathway: RNA Polymerase III Transcription  from Reactome  [70 molecules]
Authored: Hernandez, N, 2003-09-11 07:42:29.

Summary:  Authored: Hernandez, N, 2003-09-11 07:42:29

  • ... RNA Polymerase III Transcription ...
  • ... Reactome ...
  • ... reactome.
  • Authored: Hernandez, N, 2003-09-11 07:42:29 ...
  • ... RNA polymerase III is one of three types of nuclear RNA polymerases. ... of RNA polymerase II elongation, whereas some others have still unknown functions. ... Like other RNA polymerases, RNA polymerase III cannot recognize its target promoters directly.
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Pathway: RNA Polymerase II Transcription Elongation  from Reactome  [73 molecules]
The mechanisms governing the process of elongation during eukaryotic mRNA synthesis are being unraveled by recent studies.

Summary:  The mechanisms governing the process of elongation during eukaryotic mRNA synthesis are being unraveled by recent studies. These studies have led to the expected discovery of a diverse collection of transcription factors that directly regulate the activities of RNA Polymerase II and unexpected discovery of roles for many elongation factors in other basic processes like DNA repair, recombination, etc. The transcription machinery and structural features of the major RNA polymerases are conserved across species. The genes active during elongation fall under different classes like, housekeeping, cell-cycle regulated, development and differentiation specific genes etc. The list of genes involved in elongation has been growing in recent times, and include: -TFIIS,DSIF, NELF, P-Tefb etc. that are involved in drug induced or sequence-dependent arrest - TFIIF, ELL, elongin, elongator etc. that are involved in increasing the catalytic rate of elongation by altering the Km and/or the Vmax of Pol II -FACT, Paf1 and other factors that are involved chromatin modification - DNA repair proteins, RNA processing and export factors, the 19S proteasome and a host of other factors like Spt5-Spt5, Paf1, and NELF complexes, FCP1P etc. (Arndt and Kane, 2003). Elongation also represents processive phase of transcription in which the activities of several mRNA processing factors are coupled to transcription through their binding to RNA polymerase (Pol II). One of the key events that enables this interaction is the differential phosphorylation of Pol II CTD. Phosphorylation pattern of CTD changes during transcription, most significantly at the beginning and during elongation process. TFIIH-dependent Ser5 phosphorylation is observed primarily at promoter regions while P-Tefb mediated Ser2 phosphorylation is seen mainly in the coding regions, during elongation. Experimental evidence suggests a dynamic association of RNA processing factors with differently modified forms of the polymerase during the transcription cycle. (Komarnitsky et al., 2000). [Komarnitsky et al 2000, Arndt & Kane 2003, Shilatifard et al 2003]

  • ... RNA Polymerase II Transcription Elongation ...
  • ... Reactome ...
  • ... reactome.
  • ... RNA Polymerase II Transcription Elongation 271828. ... of transcription factors that directly regulate the activities of RNA Polymerase II and unexpected. ... to transcription through their binding to RNA polymerase (Pol II).
  • Different phosphorylated forms of RNA polymerase II ...