This portal has not been updated since October 2011. Please use the new PC2 web services.
Send us your feedback.  Sign up for Pathway Commons announcements.  RSS Logo RSS Feed

Searched for: REACTOME AND Nucleotide Excision Repair [All Organisms, All Data Sources]

Your search has found 64 relevant records:

Narrow Results:

Pathways (64)Molecules (48)
Showing Results 1 - 10 of 64  | Next 10
0%0%
Pathway: Base-Excision Repair, AP Site Formation  from Reactome  [63 molecules]
Base excision repair is initiated by DNA glycosylases that hydrolytically cleave of the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base (Lindahl and Wood, 1999).

Summary:  Base excision repair is initiated by DNA glycosylases that hydrolytically cleave of the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base (Lindahl and Wood, 1999).

  • Base-Excision Repair, AP Site Formation ...
  • ... Reactome ...
  • ... reactome.
  • Base excision repair is initiated by DNA glycosylases that hydrolytically cleave of the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base (Lindahl and Wood, 1999.
  • A quantitative model of human DNA base excision repair.
0%0%
Pathway: Base Excision Repair  from Reactome  [109 molecules]
Authored: Joshi-Tope, G, 2003-07-14 15:01:00.

Summary:  Authored: Joshi-Tope, G, 2003-07-14 15:01:00

  • Base Excision Repair ...
  • ... Reactome ...
  • ... reactome.
  • ... in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number. ... DNA base excision repair.
  • ... for the repair of the most prevalent types of DNA lesions, alterations, which arise intracellularly ...
0%0%
Pathway: DNA Repair  from Reactome  [309 molecules]
Edited: Matthews, L, Gopinathrao, G, 0000-00-00 00:00:00.

Summary:  Edited: Matthews, L, Gopinathrao, G, 0000-00-00 00:00:00

  • ... that include nucleotide excision repair (NER), base excision repair (BER), DNA strand break repair (DSBR. ...DNA Repair ...
  • ... Reactome ...
  • ... reactome.
  • DNA Repair ...
  • DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity. ... to the integrity of DNA and its nucleotide components.
0%0%
Pathway: Nucleotide Excision Repair  from Reactome  [96 molecules]
NER was first described in the model organism E.

Summary:  NER was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recovery of DNA synthesis and cell survival. Deficient NER processes have been identified from the cells of cancer-prone patients with different variants of xeroderma pigmentosum (XP), trichothiodystrophy (TTD), and Cockayne’s syndrome. These XP cells exhibited an ultraviolet radiation hypersensitivity leading to a hypermutability response to UV, offering a direct connection between deficient NER, increased mutations, and cancer. While the NER pathway in prokaryotes is unique, the pathway utilized in yeast and higher eukaryotes is highly conserved and includes a variety of proteins that interact to form complexes.

  • ... Nucleotide Excision Repair ...
  • ... Reactome ...
  • ... reactome.
  • ... excision repair protects against cancer.
  • Quality control by DNA repair ...
  • ... Reactome. ... in the repair of bulky adducts in DNA, such as UV-induced photo lesions [of both 6-4 photoproducts (6-4 pps ...
0%0%
Pathway: Base-free sugar-phosphate removal via the single-nucleotide replacement pathway  from Reactome  [26 molecules]
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase by APE1, APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, recruitment of POL Beta to the AP site and Excision of the abasic sugar phosphate (dRP) residue at the strand break (Lindahl and Wood, 1999).

Summary:  Base-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase by APE1, APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, recruitment of POL Beta to the AP site and Excision of the abasic sugar phosphate (dRP) residue at the strand break (Lindahl and Wood, 1999).

  • Base-free sugar-phosphate removal via the single-nucleotide replacement pathway ...
  • ... Reactome. ... sugar-phosphate removal via the single-nucleotide replacement pathway ...
  • Base-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase. ..., recruitment of POL Beta to the AP site and Excision of the abasic sugar phosphate (dRP) residue.
  • Quality control by DNA repair ...
0%0%
Pathway: Translesion synthesis by DNA polymerases bypassing lesion on DNA template  from Reactome  [15 molecules]
Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carcinogenesis and/or cell death.

Summary:  Ubiquitous environmental and endogenous genotoxic agents cause lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carcinogenesis and/or cell death. While cells posses repair mechanisms like nucleotide excision and base excision repair pathways to maintain the integrity of the genome, not all lesions on the genome can be repaired efficiently by these processes in time for DNA replication, and some types of lesion are repaired very inefficiently. To prevent acute cell death through arrested DNA replication at unrepaired lesions, cells have a mechanism, referred to as translesion synthesis, which allows DNA synthesis to proceed past lesions (Masutani et al., 2000).

  • ... posses repair mechanisms like nucleotide excision and base excision repair pathways to maintain.
  • ... Reactome 271828. ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • Quality control by DNA repair ...
0%0%
Pathway: Resolution of AP sites via the single-nucleotide replacement pathway  from Reactome  [39 molecules]
Authored: Matthews, L, 2004-02-09 03:00:00.

Summary:  Authored: Matthews, L, 2004-02-09 03:00:00

  • ... via the single-nucleotide replacement pathway ...
  • The single-nucleotide replacement pathway of base excision repair appears to facilitate the repair of most damaged bases. ...Resolution of AP sites via the single-nucleotide replacement pathway ...
  • ... Reactome ...
  • ... Reactome stable identifier.
0%0%
Pathway: Resolution of AP sites via the multiple-nucleotide patch replacement pathway  from Reactome  [52 molecules]
Authored: Matthews, L, 2004-02-09 03:00:00.

Summary:  Authored: Matthews, L, 2004-02-09 03:00:00

  • Resolution of AP sites via the multiple-nucleotide patch replacement pathway ...
  • ... Reactome 271828. ... of AP sites via the multiple-nucleotide patch replacement pathway ...
  • While the single-nucleotide replacement pathway appears to facilitate the repair. ... Second pathway for completion of human DNA base excision-repair< [Cont. ...] reconstitution with purified.
  • ... Reactome stable identifier.
0%0%
Pathway: Removal of the Flap Intermediate  from Reactome  [44 molecules]
Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991).

Summary:  Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap.

  • ... for nucleotide excision repair.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... Reactome ...
  • ... reactome.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
0%0%
Pathway: Depyrimidination  from Reactome  [42 molecules]
Authored: Matthews, L, 2004-02-09 03:00:00.

Summary:  Authored: Matthews, L, 2004-02-09 03:00:00

  • Quality control by DNA repair ...
  • ... Reactome stable.
  • ... Reactome ...
  • ... reactome.
  • ... Depyrimidination of a damaged nucleotide is mediated by a pyrimidine-specific DNA glycosylase. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...