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Searched for: REACTOME AND M Phase [All Organisms, All Data Sources]

Your search has found 353 relevant records:

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Pathways (353)Molecules (6)
Showing Results 1 - 10 of 353  | Next 10
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Pathway: M Phase  from Reactome  [185 molecules]
Mitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced.

Summary:  Mitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Finally, cytokinesis leads to cell division. The phase between two M phases is called the interphase; it encompasses the G1, S, and G2 phases of the cell cycle.

  • ... M Phase ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • Mitosis, or the M phase, involves nuclear division and cytokinesis. ..., anaphase, and telophase. ... The phase between two M phases. ... annotation of the M phase will be completed in a later version of GK.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Synthesis of DNA  from Reactome  [184 molecules]
The actual synthesis of DNA occurs in the S phase of the cell cycle.

Summary:  The actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of the primer. The DNA replication preinitiation events begin in late M or early G1 phase.

  • ... begin in late M or early G1 phase.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • The actual synthesis of DNA occurs in the S phase ...
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Pathway: DNA Replication Pre-Initiation  from Reactome  [130 molecules]
Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39.

Summary:  Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39

  • ... Reactome ...
  • ... reactome.
  • Homo sapiens. ..., O'Donnell, M, Tye, BK, 2006-03-17 16:01:39 ...
  • Although, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Phase 1 - Functionalization of compounds  from Reactome  [210 molecules]
Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound.

Summary:  Phase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemically reactive would facilitate their excretion but also increases their chance of reacting with cellular macromolecules (e.g. proteins, DNA). There is a fine balance between producing a more reactive metabolite and conjugation reactions.

  • ... Phase 1 - Functionalization of compounds ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • ... Phase 1 of metabolism is concerned with ibfunctionalization/b/i, that is the introduction or exposure of functional groups on the chemical structure of a compound. ... This provides a 'handle' for phase 2. ... PAHs) so would not necessarily undergo a phase 2 reaction. ... Making them more chemically ...
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Pathway: G2/M Checkpoints  from Reactome  [77 molecules]
G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle.

Summary:  G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they follow normal transition to the M phase. However, if any of these checkpoints fail, mitotic entry is prevented by specific G2/M checkpoint events.

  • ... If cells pass these checkpoints, they follow normal transition to the M phase. ...G2/M Checkpoints ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • ... this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: SCF(Skp2)-mediated degradation of p27/p21  from Reactome  [78 molecules]
Reviewed: Coqueret, O, 2006-10-06 08:59:06.

Summary:  Reviewed: Coqueret, O, 2006-10-06 08:59:06

  • ... of p27/p21 continues from late G1 through M-phase. ... During G0 and from early G1 to G1/S, Skp2 is degraded. ... M-phase by the association of unphosphorylated Cdh1 with the APC/C. ... APC/C(Cdh1) remains active. ... in S phase ...
  • Tyers, M ...
  • Pagano, M ...
  • ... REACTOME ...
  • ... p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells ...
  • Rape, M 271828 ...
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Pathway: Early Phase of HIV Life Cycle  from Reactome  [158 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Early Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • ... In the bearly phase /b of HIV lifecycle, an active virion binds and enters a target cell mainly by specific. ... Authored: Iordanskiy, S, Morrow, MP, Gopinathrao, G, D'Eustachio, P, Bukrinsky, M, 2006-05-16 18:51:52 ...
  • ... Reactome stable identifier.
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Pathway: Polo-like kinase mediated events  from Reactome  [22 molecules]
At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A.

Summary:  At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A. Plk1 also phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.

  • PUBMED ...
  • ... M-phase. ...Polo [Cont. ...] kinase mediated events ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Unwinding of DNA  from Reactome  [17 molecules]
DNA Replication is regulated accurately and precisely by various protein complexes.

Summary:  DNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M phase of the cell cycle. DNA helicase activity of some of the MCM family proteins are important for the unwinding of DNA and initiation of replication processes. This section contains four events which have been proved in different eukaryotic experimental systems to involve various proteins for this essential step during DNA Replication.

  • ... -Replication Complexes (pre-RC) at the end of M phase of the cell cycle. ... DNA helicase activity of some.
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • Mechali, M ...
  • Maiorano, D ...
  • ... to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: Cyclin A:Cdk2-associated events at S phase entry  from Reactome  [131 molecules]
Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27.

Summary:  Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. After forming in the cytoplasm, the Cyclin A:Cdk2 complexes are translocated to the nucleus (Jackman et al.,2002). Prior to S phase entry, the activity of Cyclin A:Cdk2 complexes is negatively regulated through Tyr 15 phosphorylation of Cdk2 (Gu et al., 1995) and also by the association of the cyclin kinase inhibitors (CKIs), p27 and p21. Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK2 kinase activity (Aprelikova et al., 1995). The entry into S phase is promoted by the removal of inhibitory Tyr 15 phosphates from the Cdk2 subunit of Cyclin A:Cdk2 complex by the Cdc25 phosphatases (Blomberg and Hoffmann, 1999) and by SCF(Skp2)-mediated degradation of p27/p21 (see Ganoth et al., 2001). While Cdk2 is thought to play a primary role in regulating entry into S phase, recent evidence indicates that Cdk1 is equally capable of promoting entry into S phase and the initiation of DNA replication (see Bashir and Pagano, 2005). Thus, Cdk1 complexes may also play a significant role at this point in the cell cycle.

  • Cyclin A:Cdk2-associated events at S phase entry ...
  • ... Reactome ...
  • ... reactome.
  • Homo sapiens ...
  • NCBI_TAXONOMY ...
  • Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. ... During G1 phase of the cell cycle, cyclin A is synthesized and associates.
  • Authored: Pagano, M, 2006-09-19 08:23:10 ...
  • ... Reactome stable identifier.