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Searched for: REACTOME AND Interferon gamma signaling [All Organisms, All Data Sources]

Your search has found 25 relevant records:

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Pathways (25)Molecules (4)
Showing Results 1 - 10 of 25  | Next 10
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Pathway: Interferon gamma signaling  from Reactome  [55 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon gamma signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... Interferon-gamma [Cont. ...] (IFN-gamma) belongs to the type II interferon family and is secreted. ... which in turn induces genes containing the gamma-interferon [Cont. ...] activation sequence (GAS) in the promoter. ... signaling ...
  • ... Reactome stable ...
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Pathway: Interferon Signaling  from Reactome  [142 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon Signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... Interferon-gamma [Cont. ...] such as omega, epsilon, and kappa), Type II (IFN-gamma) and Type III (IFN-lamda). ... In this module we are mainly focusing on type I IFNs alpha and beta and type II IFN-gamma.
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Pathway: Interferon (IFN)-gamma mediated induction of ceruloplasmin expression
Edited: Matthews, L, 0000-00-00 00:00:00.

Summary:  Edited: Matthews, L, 0000-00-00 00:00:00

  • ... Interferon (IFN)-gamma mediated induction of ceruloplasmin expression ...
  • ... Reactome ...
  • ... reactome.
  • ... Interferon (IFN)-gamma. ... Interferon (IFN)-gamma induces Cp mRNA and protein. ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: TRIF mediated TLR3 signaling  from Reactome  [119 molecules]
Authored: Shamovsky, V, 2011-03-16.

Summary:  Authored: Shamovsky, V, 2011-03-16

  • TRIF mediated TLR3 signaling ...
  • ... Reactome ...
  • ... reactome.
  • TIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known. ... in Toll-like receptor 3-mediated interferon-beta induction ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Interferon alpha/beta signaling  from Reactome  [99 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon alpha/beta signaling ...
  • ... Reactome ...
  • ... reactome.
  • Phosphorylated interferon-alpha receptor 1. ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome. ... REACTOME ...
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Pathway: Regulation of IFNA signaling  from Reactome  [58 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • Regulation of IFNA signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... I IFN signaling.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome. ... and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling ...
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Pathway: Activated TLR4 signalling  from Reactome  [170 molecules]
Reviewed: Gillespie, ME, 2010-11-30.

Summary:  Reviewed: Gillespie, ME, 2010-11-30

  • ... Reactome ...
  • ... reactome.
  • ... ability to recruit four adapters to activate two distinct signaling pathways. ... inducing interferon-beta) and TRAM (TRIF-related adapter molecule). ... The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB. ...pAlthough the current model of TLR4 signaling pathway describes ...
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Pathway: Inhibition of IFN-beta  from Reactome  [4 molecules]
Since the presence of intracellular dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis the simplest model for viral NS1 protein function is that it sequesters dsRNA and thus prevents the downstream signaling required to activate IRF-3, NF-kB and AP-1.

Summary:  Since the presence of intracellular dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis the simplest model for viral NS1 protein function is that it sequesters dsRNA and thus prevents the downstream signaling required to activate IRF-3, NF-kB and AP-1. These findings are strongly supported by mutational analyses of NS1 that indicate that the IFN antagonist properties of NS1 depend on its ability to bind dsRNA. However, a compensatory mutation (S42G), which was acquired during the passaging of the mutant RNA-binding virus, results in partial restoration of wild-type phenotype but does not restore RNA binding. This indicates that the ability of NS1 to inhibit IFN synthesis is not solely dependent on dsRNA binding and that additional mechanisms may be involved.

  • ... Reactome ...
  • ... reactome.
  • ... dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis. ... signaling required to activate IRF-3, NF-kB and AP-1.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: Inhibition of Interferon Synthesis  from Reactome  [4 molecules]
Interferon Synthesis is inhibited.

Summary:  Interferon Synthesis is inhibited.

  • Inhibition of Interferon Synthesis ...
  • ... Reactome ...
  • ... reactome.
  • ... Interferon. ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  from Reactome  [23 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling ...
  • ... Reactome ...
  • ... in TLR7/8 or 9 signaling ...
  • ... I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005. ...p TLR7/8 signaling was shown to induce IRF5. ... reported to be implicated in TLR9 signaling.