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Searched for: REACTOME AND Interferon alpha/beta signaling [All Organisms, All Data Sources]

Your search has found 25 relevant records:

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Pathways (25)Molecules (4)
Showing Results 1 - 10 of 25  | Next 10
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Pathway: Interferon Signaling  from Reactome  [142 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon Signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... interferon lambda has three members: lamda1 (IL-29), lambda2 (IL-28A), and lambda3 (IL-28B ...
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Pathway: Interferon alpha/beta signaling  from Reactome  [99 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon alpha/beta signaling ...
  • ... Reactome ...
  • ... reactome.
  • Phosphorylated interferon-alpha receptor 1.
  • ... Interferon-alpha-de [Cont. ...] activation of Tyk2 requires phosphorylation of positive. ... heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha ...
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Pathway: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  from Reactome  [23 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling ...
  • ... Reactome ...
  • ... for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction ...
  • ... in TLR7/8 or 9 signaling ...
  • ... I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005 ...
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Pathway: Toll Receptor Cascades  from Reactome  [287 molecules]
Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00.

Summary:  Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00

  • ... of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. ... There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs.
  • ... Reactome ...
  • ... reactome.
  • Toll-like receptor signaling ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways  from Reactome  [132 molecules]
RIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm.

Summary:  RIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. Functionally RIG-I and MDA5 positively regulate the IFN genes in a similar fashion, however they differ in their response to different viral species. RIG-I is essential for detecting influenza virus, Sendai virus, VSV and Japanese encephalitis virus (JEV), whereas MDA5 is essential in sensing encephalomyocarditis virus (EMCV), Mengo virus and Theiler's virus, all of which belong to the picornavirus family. RIG-I and MDA5 signalling results in the activation of IKK epsilon and (TKK binding kinase 1) TBK1, two serine/threonine kinases that phosphorylate interferon regulatory factor 3 and 7 (IRF3 and IRF7). Upon phosphorylation, IRF3 and IRF7 translocate to the nucleus and subsequently induce interferon alpha (IFNA) and interferon beta (IFNB) gene transcription.

  • ... Reactome ...
  • ... to the nucleus and subsequently induce interferon alpha (IFNA) and interferon beta (IFNB) gene transcription.
  • ... epsilon and (TKK binding kinase 1) TBK1, two serine/threonine kinases that phosphorylate interferon.
  • Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity ...
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Pathway: Viral dsRNA:TLR3:TRIF Complex Activates RIP1  from Reactome  [26 molecules]
Edited: Shamovsky, V, 2009-12-16.

Summary:  Edited: Shamovsky, V, 2009-12-16

  • ... -interacting protein 1 (RIP1) mediates the activation of interferon-alpha/ via intermediate.
  • ... Reactome ...
  • ... reactome. ...-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Interferon gamma signaling  from Reactome  [55 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon gamma signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... signaling ...
  • ... Reactome stable.
  • ... Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted ...
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Pathway: TRIF mediated TLR3 signaling  from Reactome  [119 molecules]
Authored: Shamovsky, V, 2011-03-16.

Summary:  Authored: Shamovsky, V, 2011-03-16

  • ... in Toll-like receptor 3-mediated interferon-beta induction ...
  • ... Reactome stable identifier. ...TRIF mediated TLR3 signaling ...
  • ... Reactome ...
  • ... reactome.
  • TRIF mediated TLR3 signaling ...
  • TIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Regulation of IFNA signaling  from Reactome  [58 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • Regulation of IFNA signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... I IFN signaling.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome. ... and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling ...
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Pathway: Activated TLR4 signalling  from Reactome  [170 molecules]
Reviewed: Gillespie, ME, 2010-11-30.

Summary:  Reviewed: Gillespie, ME, 2010-11-30

  • ... inducing interferon-beta) and TRAM (TRIF-related adapter molecule). ... The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons. ... couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta ...
  • ... Reactome ...
  • ... reactome.
  • ... ability to recruit four adapters to activate two distinct signaling pathways.