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Searched for: REACTOME AND Interferon Signaling [All Organisms, All Data Sources]

Your search has found 25 relevant records:

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Pathways (25)Molecules (4)
Showing Results 1 - 10 of 25  | Next 10
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Pathway: Interferon gamma signaling  from Reactome  [55 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon gamma signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... signaling ...
  • ... Reactome stable.
  • ... Interferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted. ..., whereas IFNGR2 do not bind IFNG independently but mainly plays a role in IFNG signaling ...
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Pathway: Interferon Signaling  from Reactome  [142 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon Signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... interferon lambda has three members: lamda1 (IL-29), lambda2 (IL-28A), and lambda3 (IL-28B) respectively. ... IFN-lambda signaling is initiated through unique heterodimeric receptor composed. ...-interferon-media [Cont. ...] signalling ...
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Pathway: TRIF mediated TLR3 signaling  from Reactome  [119 molecules]
Authored: Shamovsky, V, 2011-03-16.

Summary:  Authored: Shamovsky, V, 2011-03-16

  • TRIF mediated TLR3 signaling ...
  • ... Reactome ...
  • ... reactome.
  • TIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known. ... in Toll-like receptor 3-mediated interferon-beta induction ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Interferon alpha/beta signaling  from Reactome  [99 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • ... Interferon alpha/beta signaling ...
  • ... Reactome ...
  • ... reactome.
  • Phosphorylated interferon-alpha receptor 1. ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome. ... REACTOME ...
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Pathway: Regulation of IFNA signaling  from Reactome  [58 molecules]
Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17.

Summary:  Reviewed: Abdul-Sater, AA, Schindler, C, 2010-08-17

  • Regulation of IFNA signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... I IFN signaling.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome. ... and mechanisms involved in controlling the extent of ligand stimulation of IFNA/B signaling ...
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Pathway: Activated TLR4 signalling  from Reactome  [170 molecules]
Reviewed: Gillespie, ME, 2010-11-30.

Summary:  Reviewed: Gillespie, ME, 2010-11-30

  • ... Reactome ...
  • ... reactome.
  • ... ability to recruit four adapters to activate two distinct signaling pathways. ... inducing interferon-beta) and TRAM (TRIF-related adapter molecule). ... The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB. ...pAlthough the current model of TLR4 signaling pathway describes ...
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Pathway: Inhibition of IFN-beta  from Reactome  [4 molecules]
Since the presence of intracellular dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis the simplest model for viral NS1 protein function is that it sequesters dsRNA and thus prevents the downstream signaling required to activate IRF-3, NF-kB and AP-1.

Summary:  Since the presence of intracellular dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis the simplest model for viral NS1 protein function is that it sequesters dsRNA and thus prevents the downstream signaling required to activate IRF-3, NF-kB and AP-1. These findings are strongly supported by mutational analyses of NS1 that indicate that the IFN antagonist properties of NS1 depend on its ability to bind dsRNA. However, a compensatory mutation (S42G), which was acquired during the passaging of the mutant RNA-binding virus, results in partial restoration of wild-type phenotype but does not restore RNA binding. This indicates that the ability of NS1 to inhibit IFN synthesis is not solely dependent on dsRNA binding and that additional mechanisms may be involved.

  • ... Reactome ...
  • ... reactome.
  • ... dsRNA serves as the signal for virus infection and triggers host interferon (IFN) synthesis. ... signaling required to activate IRF-3, NF-kB and AP-1.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: Inhibition of Interferon Synthesis  from Reactome  [4 molecules]
Interferon Synthesis is inhibited.

Summary:  Interferon Synthesis is inhibited.

  • Inhibition of Interferon Synthesis ...
  • ... Reactome ...
  • ... reactome.
  • ... Interferon. ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling  from Reactome  [23 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling ...
  • ... Reactome ...
  • ... in TLR7/8 or 9 signaling ...
  • ... I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005. ...p TLR7/8 signaling was shown to induce IRF5. ... reported to be implicated in TLR9 signaling.
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Pathway: Toll Receptor Cascades  from Reactome  [287 molecules]
Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00.

Summary:  Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00

  • ... of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. ... There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs.
  • ... Reactome ...
  • ... reactome.
  • Toll-like receptor signaling ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.