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Searched for: REACTOME AND Interactions of Rev with host cellular proteins [All Organisms, All Data Sources]

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Pathways (90)Molecules (2)
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Pathway: Interactions of Rev with host cellular proteins  from Reactome  [69 molecules]
Reviewed: Kumar, A, 2007-01-31 22:47:49.

Summary:  Reviewed: Kumar, A, 2007-01-31 22:47:49

  • ... Interactions of Rev with host cellular proteins ...
  • ... Reactome ...
  • ... reactome.
  • Reviewed: Kumar, A, 2007-01-31 22:47:49 ...
  • In order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles. ... in the nucleus, produce a gradient of Ran-GTP/GDP required for this shuttling of Rev and other cellular ...
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Pathway: HIV Infection  from Reactome  [534 molecules]
The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected.

Summary:  The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion with contaminated blood products, injection drug use, occupational exposure,accidental needlesticks or mother-to-child transmission. HIV damages the immune system, leaving the infected person vulnerable to a variety of "opportunistic" infections arising from host immune impairment (Hare, 2004).

  • ... responses (innate, cellular and humoral) of the host. ... HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in these host-pathogen interactions (Li et al. ... auxiliary proteins in viral pathogenesis and host-pathogen interactions ...
  • ... , and Env), regulatory proteins (Tat and Rev), and accessory proteins (Vpu, Vpr, Vif, and Nef.
  • ... Reactome ...
  • ... reactome.
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Pathway: Host Interactions of HIV factors  from Reactome  [242 molecules]
Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery.

Summary:  Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein.

  • ... Host Interactions of HIV factors ...
  • ... Reactome ...
  • ... reactome.
  • Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. ... HIV-1 Vpr and Rev proteins play key roles in this co-optation.
  • Reviewed: Benarous, R, Zhao, RY, Peterlin, BM, 2006-10-30 22:12:28 ...
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Pathway: Nuclear import of Rev protein  from Reactome  [50 molecules]
Reviewed: Kumar, A, 2007-01-31 22:47:49.

Summary:  Reviewed: Kumar, A, 2007-01-31 22:47:49

  • Nuclear import of Rev involves the cellular proteins including importin-beta. ...Nuclear import of Rev protein ...
  • ... Reactome ...
  • ... reactome.
  • Nuclear import of Rev protein ...
  • Reviewed: Kumar. ... domain of the Rev protein. ... The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. ... The Rev-importin β-B23 ...
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Pathway: Interactions of Tat with host cellular proteins  from Reactome  [5 molecules]
Edited: Matthews, L, 2006-03-24 13:43:41.

Summary:  Edited: Matthews, L, 2006-03-24 13:43:41

  • ... Interactions of Tat with host cellular proteins ...
  • ... Reactome ...
  • ... reactome.
  • The elongation of HIV-1 mRNA depends upon the interaction of Tat with the host P. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Antigen processing: Ubiquitination & Proteasome degradation  from Reactome  [85 molecules]
Reviewed: Elliott, T, 2011-02-10.

Summary:  Reviewed: Elliott, T, 2011-02-10

  • ... or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can.
  • ... Reactome ...
  • ... The protease responsible for the degradation of K48-polyubiquitinated proteins is the 26S proteasome. ... proteins from the cell by degrading them into short peptides; only a small fraction of the peptides.
  • Antigen presentation and the ubiquitin-proteasome system in host-pathogen ...
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Pathway: Interactions of Vpr with host cellular proteins  from Reactome  [53 molecules]
Authored: Matthews, L, 2006-05-15 07:16:46.

Summary:  Authored: Matthews, L, 2006-05-15 07:16:46

  • ... Interactions of Vpr with host cellular proteins ...
  • ... Reactome ...
  • ... reactome.
  • ... Interactions of Vpr with host cellular. ...brbr Interactions between Vpr and host nucleoporins.
  • HIV-1 viral protein R (Vpr) & host cellular responses ...
  • Roles of HIV-1 auxiliary proteins in viral pathogenesis and host ...
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Pathway: Class I MHC mediated antigen processing & presentation  from Reactome  [188 molecules]
Reviewed: Elliott, T, 2011-02-10.

Summary:  Reviewed: Elliott, T, 2011-02-10

  • ... and the ubiquitin-proteasome system in host-pathogen interactions ...
  • ... Reactome ...
  • ... They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell. ... or foreign proteins. ... MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC.
  • Annu Rev Immunol 14:369-96 271828 ...
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Pathway: Tight junction interactions  from Reactome  [15 molecules]
Authored: Matthews, L, 2009-05-15 19:26:33.

Summary:  Authored: Matthews, L, 2009-05-15 19:26:33

  • Tight junction interactions ...
  • ... Reactome ...
  • ... reactome.
  • ... of the epithelial junctional complex forming a belt-like structure at the cellular junction. ... membrane claudin proteins. ... The TJs act as a primary barrier to the diffusion of solutes through. ... of intramembrane proteins and lipids and thus create a boundary between the apical and the basolateral ...
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Pathway: Early Phase of HIV Life Cycle  from Reactome  [158 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • ... interactions of the viral envelope proteins with host cell surface receptors. ... The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. ...Early Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • ... into host cell DNA. ... The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. ... The host DNA repair enzymes probably repair the breaks in DNA at the sites ...