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Searched for: REACTOME AND Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [All Organisms, All Data Sources]

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Pathway: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components  from Reactome  [22 molecules]
Reviewed: Peters, JM, 2006-03-27 22:55:09.

Summary:  Reviewed: Peters, JM, 2006-03-27 22:55:09

  • ... Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components ...
  • ... Reactome ...
  • ... reactome.
  • ... The APC/C may be inhibited directly by association with the Mitotic Checkpoint Complex (MCC ...
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Pathway: Inactivation of APC/C via direct inhibition of the APC/C complex  from Reactome  [21 molecules]
Reviewed: Peters, JM, 2006-03-27 22:55:09.

Summary:  Reviewed: Peters, JM, 2006-03-27 22:55:09

  • Inactivation of APC/C via direct inhibition of the APC/C complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Checkpoint inhibition of the APC/C in HeLa cells is mediated. ... Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding ...
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Pathway: SCF(Skp2)-mediated degradation of p27/p21  from Reactome  [78 molecules]
Reviewed: Coqueret, O, 2006-10-06 08:59:06.

Summary:  Reviewed: Coqueret, O, 2006-10-06 08:59:06

  • ... Inhibition of APC/C(Cdh1) activity results in an accumulation of cyclins, which leads. ... by the anaphase promoting complex/Cyclosome and its activator Cdh1 [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). ... The tight regulation of APC/C(Cdh1) activity ensures the timely elimination Skp2 and, thus, plays a critical role in controlling the G1/S transition. ... APC/C(Cdh1) becomes active in late M-phase by the association of unphosphorylated Cdh1 with the APC/C.
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Pathway: G2/M DNA damage checkpoint  from Reactome  [54 molecules]
Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation.

Summary:  Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes.

  • G2/M DNA damage checkpoint ...
  • ... Reactome ...
  • ... reactome.
  • Throughout the cell cycle. ... DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. ... The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). ... Failure of the G2 DNA damage checkpoint leads ...
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Pathway: Inhibition of Insulin Secretion by Adrenaline/Noradrenaline  from Reactome  [19 molecules]
Reviewed: D'Eustachio, P, 2009-06-02 00:48:17.

Summary:  Reviewed: D'Eustachio, P, 2009-06-02 00:48:17

  • ... Inhibition of Insulin Secretion by Adrenaline/Noradrenaline ...
  • ... Reactome ...
  • ... reactome.
  • ... Inhibition of Insulin Secretion.
  • Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma. ... Four effects are seen in the cells:br1. ... Inhibition of exocytosis of secretory granules. ... of the cell. ... Closing of L-type voltage-dependent calcium channels and inhibition of calcium ...
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Pathway: Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor  from Reactome  [20 molecules]
Authored: Jassal, B, 2004-12-17 11:53:55.

Summary:  Authored: Jassal, B, 2004-12-17 11:53:55

  • Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor ...
  • ... Reactome.
  • ... REACTOME ...
  • ... -ligand binding initiates the second proteolytic cleavage of Notch receptor ...
  • ... in the Notch receptor occurs which relieves an inhibition on the S2 protease cleavage site proximal.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page ...
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Pathway: Inhibition of adenylate cyclase pathway  from Reactome  [16 molecules]
Edited: D'Eustachio, P, 2010-11-24.

Summary:  Edited: D'Eustachio, P, 2010-11-24

  • ... Inhibition of adenylate cyclase pathway ...
  • ... Reactome ...
  • ... reactome.
  • ... Inhibition of adenylate cyclase pathway 271828. ... of GABA B receptors results in the inhibition of adenylate cyclase activity decreasing the levels of cyclic AMP production and hence the activity of Protein kinase A.
  • ... by GABA binding to the B1 subunit and B2 subunit alters the activity of adenylate cyclase ...
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Pathway: E2F-enabled inhibition of pre-replication complex formation  from Reactome  [15 molecules]
Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex.

Summary:  Under specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk1 function is restored which leads to the disruption of pre-replicative complex. This phenomenon has been demonstrated by Bosco et al (2001) in Drosophila.

  • E2F-enabled inhibition of pre-replication complex formation ...
  • ... Reactome ...
  • ... reactome.
  • Under specific conditions, Cyclin B, a mitotic cyclin, can. ... through interaction of E2F-RB and the origin recognition complex.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Inhibition of TSC complex formation by PKB  from Reactome  [9 molecules]
Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020).

Summary:  Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020). TSC2 function is affected in at least two ways: first, phosphorylation decreases the activity of TSC2; second, phosphorylation destabilizes the TSC2 protein. This destabilization is achieved by disrupting complex formation between TSC1 and TSC2 and inducing ubiquination of the free TSC2 (PMID 12172553). Phosphorylation of complexed TSC2 by PKB induces degradation of both TSC1 and TSC2 through the proteosome pathway (PMID 121676664). Phosphorylation of complexed TSC2 by PKB may therefore result in the dissociation of the TSC1:TSC2 complex (PMID 12423332).

  • ... Inhibition of TSC complex formation by PKB ...
  • ... Reactome ...
  • ... reactome.
  • ... Inhibition of TSC complex formation by PKB 271828. ... function is affected in at least two ways: first, phosphorylation decreases the activity of TSC2; second. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable ...
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Pathway: Inhibition of Host mRNA Processing and RNA Silencing  from Reactome  [6 molecules]
The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs.

Summary:  The Influenza Virus NS1 protein inhibits the cleavage and polyadenylation specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing efficient 3' end processing of host pre-mRNAs. NS1 also inhibits the splicing of pre-mRNAs, resulting in their retention within the host cell nucleus.

  • ... Inhibition of Host mRNA Processing and RNA Silencing ...
  • ... Reactome ...
  • ... reactome.
  • ... Inhibition of Host mRNA Processing. ... specificity factor CPSF and the PABII components of the host cell 3' end processing machinery, preventing. ..., resulting in their retention within the host cell nucleus.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.