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Searched for: REACTOME AND Homologous Recombination Repair [All Organisms, All Data Sources]

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Pathways (25)Molecules (1)
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Pathway: Homologous recombination repair of replication-dependent double-strand breaks
Authored: Matthews, L, 2003-11-18 00:00:00.

Summary:  Authored: Matthews, L, 2003-11-18 00:00:00

  • ... Homologous recombination repair of replication-dependent double-strand breaks ...
  • ... Reactome ...
  • ... reactome.
  • ... Homologous recombination repair of replication-dependent DNA double-strand breaks will be described in a later version of GKB.
  • ... Reactome stable identifier.
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Pathway: Homologous recombination repair of replication-independent double-strand breaks  from Reactome  [65 molecules]
Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins.

Summary:  Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures.

  • ... Homologous recombination repair of replication-independent double-strand breaks ...
  • ... Reactome ...
  • ... reactome.
  • ... Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. ... DNA repair and signaling proteins ...
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Pathway: Homologous Recombination Repair  from Reactome  [65 molecules]
Edited: Matthews, L, 0000-00-00 00:00:00.

Summary:  Edited: Matthews, L, 0000-00-00 00:00:00

  • ... Homologous Recombination Repair ...
  • ... Reactome ...
  • ... reactome.
  • ... Repair by homologous recombination involves processing of the ends of the DNA double-strand break, homologous DNA pairing and strand exchange, repair DNA. ... information encoded by homologous sequence to repair double-strand breaks (DSBs).
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Pathway: Homologous DNA pairing and strand exchange  from Reactome  [21 molecules]
Authored: Matthews, L, 2003-11-23 12:20:00.

Summary:  Authored: Matthews, L, 2003-11-23 12:20:00

  • ... Homologous DNA pairing and strand exchange ...
  • ... Reactome ...
  • ... reactome.
  • The presynaptic phase of homologous DNA pairing. ... which it assembles and the recombining homologous duplex DNA. ... The repair proteins RPA, RAD52. ... molecules involves the invasion of homologous duplex DNA by the processed single-stranded ends ...
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Pathway: Meiotic Recombination  from Reactome  [60 molecules]
Reviewed: Strong, E, 2011-02-25.

Summary:  Reviewed: Strong, E, 2011-02-25

  • Meiotic Recombination ...
  • ... Reactome ...
  • ... reactome.
  • ... recombination exchanges segments of duplex DNA between chromosomal homologs, generating genetic diversity. ... of recombination: non-crossover (NCO) and crossover (CO). ... In mammals, the former is required for correct pairing and synapsis of homologous chromosomes, while CO intermediates called chiasmata ...
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Pathway: MRN complex relocalizes to nuclear foci  from Reactome  [10 molecules]
Authored: Matthews, L, 2003-11-23 12:20:00.

Summary:  Authored: Matthews, L, 2003-11-23 12:20:00

  • ... to double-strand breaks and have been implicated in DNA end-processing during homologous recombination repair (Trujillo et al. ... in DNA recombination and repair.
  • ... in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
  • ... Reactome ...
  • ... reactome.
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Pathway: Double-Strand Break Repair  from Reactome  [81 molecules]
Edited: Matthews, L, 0000-00-00 00:00:00.

Summary:  Edited: Matthews, L, 0000-00-00 00:00:00

  • ... normally during the processes of DNA replication, meiotic exchange, and V(D)J recombination. ... pTwo distinct mechanisms for DSB repair are the error-free homologous recombination repair (HRR) pathway. ...Double-Strand Break Repair ...
  • ... Reactome ...
  • ... reactome.
  • Double-Strand Break Repair ...
  • ... break repair during the mammalian cell cycle.
  • ... Reactome stable identifier.
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Pathway: Meiosis  from Reactome  [109 molecules]
During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II.

Summary:  During meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed in Yang and Wang 2009), and then segregated, resulting in haploid daughters containing sister chromatids paired at their centromeres (reviewed in Cohen et al. 2006, Handel and Schimenti 2010). The sister chromatids are then separated and segregated during meiosis II.

  • ... Reactome ...
  • ... reactome.
  • ... In meiosis I, the distinguishing event of meiosis, pairs (bivalents) of homologous chromosomes in the form of sister chromatids are paired, synapsed along their regions of homologous DNA (reviewed. ... Though hundreds of recombination events are initiated, most are resolved without crossovers and only tens proceed to become crossovers. ... In mammals recombination events are required ...
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Pathway: Meiotic Synapsis  from Reactome  [58 molecules]
Reviewed: Strong, E, 2011-02-25.

Summary:  Reviewed: Strong, E, 2011-02-25

  • ... Reactome ...
  • ... reactome.
  • Meiotic synapsis is the stable physical pairing of homologous chromosomes. ... to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Presynaptic phase of homologous DNA pairing and strand exchange  from Reactome  [18 molecules]
The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

Summary:  The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

  • Presynaptic phase of homologous DNA pairing and strand exchange ...
  • ... Reactome ...
  • ... of homologous DNA pairing and strand exchange ...
  • The presynaptic phase of homologous DNA pairing. ... to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.