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Searched for: REACTOME AND HIV-1 Transcription Initiation [All Organisms, All Data Sources]

Your search has found 40 relevant records:

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Pathways (40)Molecules (57)
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Pathway: HIV-1 Transcription Elongation  from Reactome  [87 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • ... HIV-1 Transcription Elongation ...
  • ... Reactome ...
  • ... reactome.
  • ... of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al. ... While initiation of transcription from the HIV-1. ... Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product 271828 ...
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Pathway: HIV-1 Transcription Initiation  from Reactome  [57 molecules]
Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme.

Summary:  Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme. This facilitates formation of the first phosphodiester bond, which marks transcription initiation. As a result of this, the TFIIB basal transcription factor dissociates from the initiation complex.

  • ... HIV-1 Transcription Initiation ...
  • ... Reactome ...
  • ... reactome.
  • ... This facilitates formation of the first phosphodiester bond, which marks transcription initiation. ... As a result of this, the TFIIB basal transcription factor dissociates from the initiation complex. ...pThe open transcription initiation complex is unstable and can revert to the closed state. ... Initiation ...
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Pathway: Transcription of the HIV genome  from Reactome  [174 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • ... Transcription of the HIV genome ...
  • ... Reactome ...
  • ... reactome.
  • Expression of the integrated HIV-1 provirus is dependent on the host cell Pol II transcription machinery, but is regulated in critical ways by HIV-1 Tat and Rev proteins. ...-acting elements that regulate Pol II-mediated transcription initiation.
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Pathway: HIV-1 Transcription Termination
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • ... HIV-1 Transcription Termination ...
  • ... Reactome ...
  • ... reactome.
  • Termination of HIV-1 transcription is believed. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ...
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Pathway: Late Phase of HIV Life Cycle  from Reactome  [232 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • ... will be covered in a later release of Reactome. ... HIV-1 gene expression is regulated by both cellular and viral proteins. ... Although the initial activation of the HIV-1 transcription is facilitated by cellular.
  • ... HIV-1 infection and regulation of Tat function in macrophages ...
  • ... Reactome.
  • ... Reactome ...
  • ... reactome.
  • The late phase of the HIV-1 life cycle includes the regulated expression ...
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Pathway: Minus-strand DNA synthesis  from Reactome  [32 molecules]
In the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA molecule as primer.

Summary:  In the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary to the HIV genomic RNA is synthesized, using the viral RNA as a template and a host cell lysine tRNA molecule as primer. The synthesis proceeds in two discrete steps, separated by a strand transfer event. As minus strand DNA is synthesized, the viral genomic RNA is degraded, also in several discrete steps. Two specific polypurine tracts (PPT sequences) in the viral RNA, one within the pol gene (central or cPPT) and one immediately preceding the U3 sequence (3' PPT) are spared from degradation and serve to prime synthesis of DNA complementary to the minus strand (plus-strand synthesis). During plus-strand synthesis, Preston and colleagues observed secondary sites of plus-strand initiation at low frequency both in the cell-free system and in cultured virus (Klarman et al., 1997). Both DNA synthesis and RNA degradation activities are catalyzed by the HIV-1 reverse transcriptase (RT) heterodimer.

  • The HIV-1 reverse transcription (RT) process as target for RT inhibitors ...
  • ... Retroviral reverse transcription and integration: progress and problems ...
  • ... Reactome stable.
  • ... Reactome ...
  • In the first part of reverse transcription, minus-strand synthesis, a DNA strand complementary. ... plus-strand synthesis, Preston and colleagues observed secondary sites of plus-strand initiation ...
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Pathway: Abortive elongation of HIV-1 transcript in the absence of Tat  from Reactome  [35 molecules]
This event was inferred from the corresponding Reactome human Poll II transcription elongation event.

Summary:  This event was inferred from the corresponding Reactome human Poll II transcription elongation event. The details specific to HIV-1 transcription elongation are described below. In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated with the HIV-1 template are non-processive. RNA Pol II is arrested after promoter clearance by the negative transcriptional elongation factors DSIF and NELF as occurs during early elongation of endogenous templates (Wada et al, 1998; Yamaguchi et al. 1999). This arrest cannot be overcome by P-TEFb mediated phosphorylation in the absence of Tat however, and elongation aborts resulting in the accumulation of short transcripts (Kao et al., 1987).

  • Abortive elongation of HIV-1 transcript in the absence of Tat ...
  • ... Reactome ...
  • ... reactome.
  • This event was inferred from the corresponding Reactome human Poll II transcription elongation event. ... The details specific to HIV-1 transcription elongation are described below. ... In the absence of the HIV-1 Tat protein, the RNA Pol II complexes associated ...
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Pathway: Formation of HIV-1 elongation complex containing HIV-1 Tat  from Reactome  [69 molecules]
This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome.

Summary:  This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

  • Formation of HIV-1 elongation complex containing HIV-1 Tat ...
  • ... Reactome ...
  • ... reactome.
  • This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. ... The details relevant to HIV-1 are described below. ... transcription event below. ... The formation of the HIV-1 elongation complex involves Tat mediated recruitment ...
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Pathway: Plus-strand DNA synthesis  from Reactome  [24 molecules]
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22.

Summary:  Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

  • The HIV-1 reverse transcription (RT) process.
  • ... Reactome ...
  • ... reactome.
  • ... Both DNA synthesis and RNA degradation are catalyzed by domains of the HIV-1. ... secondary sites of plus-strand initiation at low frequency both in the cell-free system.
  • ... Reactome stable identifier.
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Pathway: Formation of the HIV-1 Early Elongation Complex  from Reactome  [53 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • Formation of the HIV-1 Early Elongation Complex ...
  • ... Reactome ...
  • ... reactome.
  • Formation of the HIV-1 Early Elongation.
  • This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. ... The details relevant to HIV-1 are described below. ... transcription elongation.
  • ... Reactome stable identifier.