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Searched for: REACTOME AND HIV Life Cycle [All Organisms, All Data Sources]

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Pathway: Early Phase of HIV Life Cycle  from Reactome  [158 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Early Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • ... In the bearly phase /b of HIV lifecycle, an active virion binds and enters a target cell mainly by specific. ... HIV RNA genome.
  • ... Reactome stable identifier.
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Pathway: Late Phase of HIV Life Cycle  from Reactome  [232 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • Late Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • The late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. ... The assembly of viral particles will be covered in a later release of Reactome. ... HIV-1 gene expression is regulated by both cellular and viral ...
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Pathway: HIV Life Cycle  from Reactome  [381 molecules]
The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure.

Summary:  The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface (a), viral and host cell membranes fuse and the viral particle is uncoated (b), the viral genome is reverse transcribed and the viral preintegration complex (PIC) forms (c), the PIC is transported through the nuclear pore into the nucleoplasm (d), and the viral reverse transcript is integrated into a host cell chromosome (e). In the late phase, viral RNAs are transcribed from the integrated viral genome and processed to generate viral mRNAs and full-length viral genomic RNAs (f), the viral RNAs are exported through the nuclear pore into the cytosol (g), viral mRNAs are translated and the resulting viral proteins are post-translationally processed (h), core particles containing viral genomic RNA and proteins assemble at the host cell membrane and immature viral particles are released by budding. The released particles mature to become infectious (j), completing the cycle (Frankel and Young 1998; Miller and Bushman 1997).

  • ... HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • The life cycle of HIV-1 is divided into early and late. ... elucidation of the basic features of the HIV-1 life cycle was critically dependent on the intellectual. ... specific to the HIV-1 life cycle.
  • ... infectious (j), completing the cycle (Frankel and Young 1998; Miller and Bushman 1997).
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Pathway: Rev-mediated nuclear export of HIV-1 RNA  from Reactome  [59 molecules]
Reviewed: Kumar, A, 2007-01-31 22:47:49.

Summary:  Reviewed: Kumar, A, 2007-01-31 22:47:49

  • ... stages of the viral life cycle, or in the absence of the viral Rev protein, completely spliced viral. ...Rev-mediated nuclear export of HIV-1 RNA ...
  • ... Reactome ...
  • ... reactome.
  • ... HIV Rev uses a conserved.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: HIV Infection  from Reactome  [534 molecules]
The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected.

Summary:  The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion with contaminated blood products, injection drug use, occupational exposure,accidental needlesticks or mother-to-child transmission. HIV damages the immune system, leaving the infected person vulnerable to a variety of "opportunistic" infections arising from host immune impairment (Hare, 2004).

  • ... HIV Infection ...
  • ... Reactome ...
  • ... reactome.
  • The global pandemic of Human Immunodeficiency Virus (HIV. ... UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. ... The primary method of HIV infection is by sexual exposure while nonsexual HIV. ... HIV damages the immune ...
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Pathway: The role of Nef in HIV-1 replication and disease pathogenesis  from Reactome  [49 molecules]
Authored: Gillespie, ME, 2007-07-25 19:42:36.

Summary:  Authored: Gillespie, ME, 2007-07-25 19:42:36

  • ... Reactome ...
  • ... of viral replication cycle. ... it has been demonstrated that Nef plays an important role in several steps of HIV replication. ... In addition, it appears to be a critical pathogenic factor, as Nef-deficient SIV and HIV are significantly. ... characteristic to HIV disease. ...brbrThe role of Nef in HIV-1 replication and disease pathogenesis is determined ...
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Pathway: Assembly of HIV virion
This pathway module includes annotations of events leading to synthesis and organization of GAG, GAGPOL and ENV proteins.

Summary:  This pathway module includes annotations of events leading to synthesis and organization of GAG, GAGPOL and ENV proteins. This section will annotated in future.

  • Assembly of HIV virion ...
  • ... Reactome ...
  • ... reactome.
  • ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Binding and entry of HIV virion  from Reactome  [73 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Binding and entry of HIV virion ...
  • ... Reactome ...
  • ... reactome.
  • ... HIV enters cells by fusion at the cell surface, that results in a productive infection. ... The envelope (Env) protein of HIV. ... Virion and target cell membrane fusion leads to the release of HIV viral cores into the cell ...
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Pathway: Uncoating of the HIV Virion  from Reactome  [21 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Uncoating of the HIV Virion ...
  • ... Reactome ...
  • ... reactome.
  • Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Host Interactions of HIV factors  from Reactome  [242 molecules]
Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery.

Summary:  Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein.

  • Host Interactions of HIV factors ...
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME 271828 ...