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Searched for: REACTOME AND HIV Infection [All Organisms, All Data Sources]

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Pathway: HIV Infection  from Reactome  [534 molecules]
The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected.

Summary:  The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion with contaminated blood products, injection drug use, occupational exposure,accidental needlesticks or mother-to-child transmission. HIV damages the immune system, leaving the infected person vulnerable to a variety of "opportunistic" infections arising from host immune impairment (Hare, 2004).

  • ... HIV Infection ...
  • ... Reactome ...
  • ... reactome.
  • The global pandemic of Human Immunodeficiency Virus (HIV. ... The primary method of HIV infection is by sexual exposure while nonsexual HIV. ... consisting of early events occuring after HIV infection of a susceptible target cell and a br2. ... titled bHost interactions of HIV factors/b will highlight these complex post-infection processes ...
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Pathway: Binding and entry of HIV virion  from Reactome  [73 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Binding and entry of HIV virion ...
  • ... Reactome ...
  • ... reactome.
  • ... HIV enters cells by fusion at the cell surface, that results in a productive infection. ... The envelope (Env) protein of HIV. ... Virion and target cell membrane fusion leads to the release of HIV viral cores into the cell ...
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Pathway: Uncoating of the HIV Virion  from Reactome  [21 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Uncoating of the HIV Virion ...
  • ... Reactome ...
  • ... reactome.
  • Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Nef and signal transduction  from Reactome  [15 molecules]
Authored: Gillespie, ME, 2007-07-25 19:42:36.

Summary:  Authored: Gillespie, ME, 2007-07-25 19:42:36

  • ... and promote their infection by HIV.
  • ... Reactome ...
  • ... reactome.
  • ... In vitro, HIV-infected T cells produce enhanced. ... CD40L signalling pathway to promote resting-cell infection ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Late Phase of HIV Life Cycle  from Reactome  [232 molecules]
Reviewed: Peterlin, BM, 2005-01-05 00:00:00.

Summary:  Reviewed: Peterlin, BM, 2005-01-05 00:00:00

  • Late Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • HIV-1 infection and regulation of Tat function in macrophages ...
  • ... Reactome. ... of the HIV gene products and the assembly of viral particles. ... The assembly of viral particles will be covered in a later release of Reactome. ... HIV-1 gene expression is regulated by both cellular and viral ...
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Pathway: APOBEC3G mediated resistance to HIV-1 infection  from Reactome  [33 molecules]
Reviewed: Simon, V, 2007-01-30 23:07:12.

Summary:  Reviewed: Simon, V, 2007-01-30 23:07:12

  • APOBEC3G mediated resistance to HIV-1 infection ...
  • ... Reactome ...
  • ... reactome. ... infection ...
  • ... of Vif deficient HIV-1 (Sheehy 2002). ... It is expressed in cell populations that are susceptible to HIV infection (e.
  • Isolation of a human gene that inhibits HIV-1 infection and is suppressed ...
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Pathway: The role of Nef in HIV-1 replication and disease pathogenesis  from Reactome  [49 molecules]
Authored: Gillespie, ME, 2007-07-25 19:42:36.

Summary:  Authored: Gillespie, ME, 2007-07-25 19:42:36

  • ... Reactome ...
  • ... it has been demonstrated that Nef plays an important role in several steps of HIV replication. ... In addition, it appears to be a critical pathogenic factor, as Nef-deficient SIV and HIV are significantly. ... characteristic to HIV disease. ...brbrThe role of Nef in HIV-1 replication and disease pathogenesis is determined. ... infectivity and viral replication, and regulates cholesterol trafficking in HIV-infected cells.
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Pathway: Assembly of HIV virion
This pathway module includes annotations of events leading to synthesis and organization of GAG, GAGPOL and ENV proteins.

Summary:  This pathway module includes annotations of events leading to synthesis and organization of GAG, GAGPOL and ENV proteins. This section will annotated in future.

  • Assembly of HIV virion ...
  • ... Reactome ...
  • ... reactome.
  • ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Early Phase of HIV Life Cycle  from Reactome  [158 molecules]
Edited: Gopinathrao, G, 2006-02-17 18:35:46.

Summary:  Edited: Gopinathrao, G, 2006-02-17 18:35:46

  • Early Phase of HIV Life Cycle ...
  • ... Reactome ...
  • ... reactome.
  • ... In the bearly phase /b of HIV lifecycle, an active virion binds and enters a target cell mainly by specific. ... HIV RNA genome.
  • ... Reactome stable identifier.
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Pathway: Host Interactions of HIV factors  from Reactome  [242 molecules]
Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery.

Summary:  Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein.

  • Host Interactions of HIV factors ...
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME 271828 ...