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Searched for: REACTOME AND Global Genomic NER (GG-NER) [All Organisms, All Data Sources]

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Pathways (7)
Showing Results 1 - 7 of 7 
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Pathway: Global Genomic NER (GG-NER)  from Reactome  [70 molecules]
GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.

Summary:  GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.

  • ... Global Genomic NER (GG-NER) ...
  • ... Reactome ...
  • ... reactome.
  • ... GG-NER is considered. ...BR The three events that characterize NER are well characterized in GG-NER: damage recognition, bimodal incision of DNA via repair protein complex, resulting.
  • ... Reactome stable identifier.
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Pathway: Nucleotide Excision Repair  from Reactome  [96 molecules]
NER was first described in the model organism E.

Summary:  NER was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recovery of DNA synthesis and cell survival. Deficient NER processes have been identified from the cells of cancer-prone patients with different variants of xeroderma pigmentosum (XP), trichothiodystrophy (TTD), and Cockayne’s syndrome. These XP cells exhibited an ultraviolet radiation hypersensitivity leading to a hypermutability response to UV, offering a direct connection between deficient NER, increased mutations, and cancer. While the NER pathway in prokaryotes is unique, the pathway utilized in yeast and higher eukaryotes is highly conserved and includes a variety of proteins that interact to form complexes.

  • ... of two related pathways called global genomic repair (GG-NER) and transcription-coupled NER (TC-NER. ... of the participating molecules are shared between these two branches of NER". ... GG-NER is considered.
  • ... Reactome ...
  • ... reactome.
  • ... NER was first described. ... Deficient NER ...
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Pathway: Amplification of signal from the kinetochores  from Reactome  [6 molecules]
Authored: Yen, T, 2004-05-05 00:00:00.

Summary:  Authored: Yen, T, 2004-05-05 00:00:00

  • ... Reactome ...
  • ... reactome. ... to affect the global biochemical status of the cell. ... In principle, the signal that is generated. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome ...
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Pathway: Unfolded Protein Response  from Reactome  [39 molecules]
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31.

Summary:  Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

  • ... Reactome ...
  • ... reactome.
  • ... eIF2alpha kinase) leads to phosphorylation of the translation initiation factor eIF2alpha and global.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME.
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Pathway: HIV Infection  from Reactome  [534 molecules]
The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected.

Summary:  The global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million HIV/AIDS patients worldwide with 75% of them living in sub-Saharan Africa. The primary method of HIV infection is by sexual exposure while nonsexual HIV transmission also can occur through transfusion with contaminated blood products, injection drug use, occupational exposure,accidental needlesticks or mother-to-child transmission. HIV damages the immune system, leaving the infected person vulnerable to a variety of "opportunistic" infections arising from host immune impairment (Hare, 2004).

  • ... Reactome ...
  • ... reactome.
  • The global pandemic of Human Immunodeficiency Virus (HIV.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: Mitotic Spindle Checkpoint  from Reactome  [27 molecules]
Authored: Yen, T, 2004-05-05 00:00:00.

Summary:  Authored: Yen, T, 2004-05-05 00:00:00

  • ... Reactome ...
  • ... reactome.
  • ... for a localized defect to affect the global biochemical status of the cell. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier ...
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Pathway: Regulation of beta-cell development  from Reactome  [125 molecules]
Edited: D'Eustachio, P, 2008-05-12 21:43:33.

Summary:  Edited: D'Eustachio, P, 2008-05-12 21:43:33

  • ... Reactome ...
  • ... reactome.
  • ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Global gene expression profiling.
  • ... Reactome stable identifier.