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Searched for: REACTOME AND GPCR ligand binding [All Organisms, All Data Sources]

Your search has found 12 relevant records:

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Pathways (12)Molecules (15)
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Pathway: GPCR ligand binding  from Reactome  [426 molecules]
Edited: Jupe, S, 2010-02-10.

Summary:  Edited: Jupe, S, 2010-02-10

  • ... GPCR ligand binding ...
  • ... Reactome ...
  • ... reactome.
  • ... 2004) and have an equal diversity of ligand-bindingGPCR signaling involves signal transduction via heterotrimeric G. ... mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled ...
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Pathway: Signaling by GPCR  from Reactome  [640 molecules]
Authored: Jassal, B, 2008-07-02 14:14:59.

Summary:  Authored: Jassal, B, 2008-07-02 14:14:59

  • ... exchange factors; activated by ligand binding, they promote GDP-GTP exchange on associated heterotrimeric guanine nucleotide-binding (G) proteins. ... There are two models for GPCR-G Protein interactions: 1) ligand-GPCR binding first, then binding to G Proteins; 2) "Pre-coupling" of GPCRs and G Proteins before ligand binding (review Oldham WM and Hamm HE, 2008). ...Signaling by GPCR ...
  • ... Reactome ...
  • ... reactome.
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Pathway: GPCR downstream signaling  from Reactome  [151 molecules]
Reviewed: Akkerman, JW, 2009-06-03.

Summary:  Reviewed: Akkerman, JW, 2009-06-03

  • ... GPCR downstream signaling ...
  • ... Reactome ...
  • ... reactome.
  • ... of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors. ... clear that this greatly oversimplifies the complexities of GPCR signaling (see Gurevich & Gurevich.
  • ... Reactome stable identifier.
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Pathway: Activation of G protein gated Potassium channels  from Reactome  [12 molecules]
Edited: Mahajan, SS, 2011-05-22.

Summary:  Edited: Mahajan, SS, 2011-05-22

  • ... Activation of Kir 3 channels occurs after binding of G beta gamma subunits of GPCR. ... The dissociation of GPCR into G alpha and G beta gamma subunits is activated by the activation of GABA B receptor by GABA binding.
  • ... Reactome stable identifier.
  • ... Reactome ...
  • ... reactome.
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Pathway: Olfactory Signaling Pathway  from Reactome  [6 molecules]
Mammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) that are selectively expressed in the olfactory epithelium.

Summary:  Mammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) that are selectively expressed in the olfactory epithelium. This prediction was based on previous biochemical evidence that cAMP levels increased in olfactory neurons upon odor stimulation. These predictions proved to be true, and Buck and Axel received a Nobel Prize for this and subsequent work (reviewed in Keller, 2008).

  • ... pThere are two models for GPCR-G Protein interactions: 1) ligand-GPCR binding first, then binding to G Proteins; 2) "Pre-coupling" of GPCRs and G Proteins before ligand binding.
  • ... Reactome ...
  • ... reactome.
  • ... they couple binding by odorant ligands with intracellular olfactory signaling. ... (Note: the other subclasses of GPCR signaling pathways are described under "GPCR Signaling". ...)brbrThe ligands for ORs are diverse ...
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Pathway: Nucleotide-like (purinergic) receptors  from Reactome  [36 molecules]
Reviewed: D'Eustachio, P, 2009-05-29 07:44:22.

Summary:  Reviewed: D'Eustachio, P, 2009-05-29 07:44:22

  • ... Reactome ...
  • ... reactome.
  • ... The family includes the GPCR P2Y purinergic receptors and adenosine P1 receptors. ... A third family member, the P2X receptor, is a ligand-gated ion.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: G alpha (s) signalling events  from Reactome  [32 molecules]
The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A).

Summary:  The general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to collectively as Protein Kinase A). The signal from the ligand-stimulated GPCR is amplified because the receptor can activate several Gs heterotrimers before it is inactivated.

  • ... The signal from the ligand-stimulated GPCR is amplified because the receptor can activate.
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME 271828 ...
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Pathway: NGF-independant TRKA activation  from Reactome  [8 molecules]
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07.

Summary:  Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07

  • ... Reactome ...
  • ... reactome.
  • ... -coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without. ... GPCR-mediated transactivation of TRK receptors. ... page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: Signal Transduction  from Reactome  [1695 molecules]
Authored: Bevan, AP, Charalambous, M, Gopinathrao, G, Joshi-Tope, G, Rothfels, K, Orlic-Milacic, Marija, 2005--0-5-.

Summary:  Authored: Bevan, AP, Charalambous, M, Gopinathrao, G, Joshi-Tope, G, Rothfels, K, Orlic-Milacic, Marija, 2005--0-5-

  • ... Reactome ...
  • ... reactome. ... Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones. ... In the absence of ligand, beta. ... When a GPCR is activated, it acts as a guanine nucleotide exchange factor. ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome ...
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Pathway: Calcitonin-like ligand receptors  from Reactome  [14 molecules]
Reviewed: D'Eustachio, P, 2009-05-29 07:44:22.

Summary:  Reviewed: D'Eustachio, P, 2009-05-29 07:44:22

  • Calcitonin-like ligand receptors ...
  • ... Reactome ...
  • ... reactome.
  • ... for calcitonin is a conventional class B GPCR, the receptors for CGRP, AM and amylin require. ... by itself will bind no known endogenous ligand.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome ...