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Searched for: REACTOME AND G2/M DNA damage checkpoint [All Organisms, All Data Sources]

Your search has found 9 relevant records:

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Pathways (9)Molecules (5)
Showing Results 1 - 9 of 9 
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Pathway: G2/M DNA damage checkpoint  from Reactome  [54 molecules]
Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation.

Summary:  Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes.

  • ... G2/M DNA damage checkpoint ...
  • ... Reactome ...
  • ... reactome.
  • ... DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. ... The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). ... Failure of the G2 DNA damage checkpoint leads ...
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Pathway: G2/M Checkpoints  from Reactome  [77 molecules]
G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle.

Summary:  G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they follow normal transition to the M phase. However, if any of these checkpoints fail, mitotic entry is prevented by specific G2/M checkpoint events.

  • ... per cell cycle are also an example of a G2/M checkpoint. ...pIn the event of high levels of DNA damage. ...G2/M Checkpoints ...
  • ... Reactome ...
  • ... reactome.
  • ... G2/M Checkpoints ...
  • ... G2/M checkpoints include the checks for damaged DNA. ..., if any of these checkpoints fail, mitotic entry is prevented by specific G2/M checkpoint events. ...pThe G2/M checkpoints can fail due to the presence of unreplicated DNA or damaged DNA.
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Pathway: G2/M DNA replication checkpoint  from Reactome  [13 molecules]
The G2/M DNA replication checkpoint ensures that mitosis is not initiated until DNA replication is complete.

Summary:  The G2/M DNA replication checkpoint ensures that mitosis is not initiated until DNA replication is complete. If replication is blocked, the DNA replication checkpoint signals to maintain Cyclin B - Cdc2 complexes in their T14Y15 phosphorylated and inactive state. This prevents the phosphorylation of proteins involved in G2/M transition, and prevents mitotic entry.

  • ... G2/M DNA replication checkpoint ...
  • ... Reactome ...
  • ... reactome.
  • The G2/M DNA replication checkpoint ensures that mitosis is not initiated until DNA replication is complete. ... If replication is blocked, the DNA replication checkpoint signals to maintain Cyclin B - Cdc2 complexes. ... in G2/M transition, and prevents mitotic entry. ...pFailure of these checkpoints results in changes ...
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Pathway: Interactions of Vpr with host cellular proteins  from Reactome  [53 molecules]
Authored: Matthews, L, 2006-05-15 07:16:46.

Summary:  Authored: Matthews, L, 2006-05-15 07:16:46

  • ... -characterized G2/M checkpoint pathways which prevent cells from entering mitosis when cellular DNA is damaged or when DNA replication is inhibited. ... It is clear that Vpr induces cell cycle G2/M arrest. ... genes in the DNA damage checkpoint ...
  • ... Reactome ...
  • ... reactome. ..., 1997) and induction of cell cycle G2/M arrest (He et al ...
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Pathway: G2/M Transition  from Reactome  [158 molecules]
Cyclin A can also form complexes with Cdc2 (Cdk1).

Summary:  Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved in mitotic spindle structure and function, the breakdown of the nuclear envelope, and topological changes in chromosomes allowing resolution of their entanglement and condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis.

  • ... G2/M Transition ...
  • ... Reactome ...
  • ... reactome.
  • ... and condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Cyclin A/B1 associated events during G2/M transition  from Reactome  [53 molecules]
Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases.

Summary:  Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).

  • Cyclin A/B1 associated events during G2/M transition ...
  • ... Reactome ...
  • ... reactome. ... G2/M transition ...
  • Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. ... The G2/M transition.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes  from Reactome  [12 molecules]
Cyclin A:Cdc2 complexes are detected in the nucleus earlier that cyclin B1:Cdc2 complexes and may play a role in the initial events in prophase.

Summary:  Cyclin A:Cdc2 complexes are detected in the nucleus earlier that cyclin B1:Cdc2 complexes and may play a role in the initial events in prophase. Inactivation of Cdc25B by proteasome-mediated degradation is dependent upon cyclin A:Cdc2-mediated phosphorylation (Cans et al, 1999)

  • Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes ...
  • ... Reactome ...
  • ... reactome.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: Centrosome maturation  from Reactome  [89 molecules]
Authored: Matthews, L, 2008-11-11 14:53:40.

Summary:  Authored: Matthews, L, 2008-11-11 14:53:40

  • ... Reactome ...
  • ... reactome.
  • ... a major reorganization of centrosomal material at the G2/M transition.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: Role of DCC in regulating apoptosis  from Reactome  [17 molecules]
Authored: Garapati, P V, 2008-07-16 14:42:16.

Summary:  Authored: Garapati, P V, 2008-07-16 14:42:16

  • ... Reactome ...
  • ... reactome.
  • Induction of apoptosis and G2/M cell cycle arrest by DCC ...
  • ... page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.