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Searched for: REACTOME AND Formation of the HIV-1 Early Elongation Complex [All Organisms, All Data Sources]

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Pathway: Formation of the HIV-1 Early Elongation Complex  from Reactome  [53 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • ... Formation of the HIV-1 Early Elongation Complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Formation of the HIV-1 Early Elongation. ... with RNA Pol II, and formation of DSIF:NELF:HIV-1 early elongation complex as described below. ... The details relevant to HIV-1 are described below. ... Formation of the early elongation. ... transcription elongation.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page ...
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Pathway: Formation of HIV-1 elongation complex in the absence of HIV-1 Tat  from Reactome  [68 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • ... Formation of HIV-1 elongation complex in the absence of HIV-1 Tat ...
  • ... Reactome ...
  • ... reactome.
  • Edited: Matthews, L, 2005-07-26 23:29:22 ...
  • Authored: Matthews, L, Rice, AP, 2005-07-27 00:00:00 ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: HIV-1 Transcription Elongation  from Reactome  [87 molecules]
Edited: Matthews, L, 2005-07-26 23:29:22.

Summary:  Edited: Matthews, L, 2005-07-26 23:29:22

  • ... of the HIV-1 protein Tat, transcription of the proviral DNA is inefficient and results in the production of truncated transcripts (Kao et al. ... While initiation of transcription from the HIV-1 LTR and formation of the early elongation complex occurs normally, transcription elongation. ...HIV-1 [Cont. ...] Transcription Elongation ...
  • ... Reactome ...
  • ... reactome.
  • ... HIV-1 Transcription Elongation ...
  • Edited: Matthews, L ...
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Pathway: Formation of HIV-1 elongation complex containing HIV-1 Tat  from Reactome  [69 molecules]
This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome.

Summary:  This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

  • ... Formation of HIV-1 elongation complex containing HIV-1 Tat ...
  • ... Reactome ...
  • ... reactome.
  • This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. ... The details relevant to HIV-1 are described below. ... The formation of the HIV-1 elongation complex involves Tat mediated recruitment ...
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Pathway: Formation of the Early Elongation Complex  from Reactome  [48 molecules]
Authored: Gopinathrao, G, 2004-05-06 22:00:00.

Summary:  Authored: Gopinathrao, G, 2004-05-06 22:00:00

  • ... Formation of the Early Elongation Complex ...
  • ... Reactome ...
  • ... reactome.
  • Transcription elongation by RNA polymerase II (RNAPII) is controlled by a number of trans-acting transcription elongation factors as well as by cis-acting elements. ... Transcription elongation is a rate-limiting step for proper mRNA production ...
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Pathway: HIV-1 Transcription Initiation  from Reactome  [57 molecules]
Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme.

Summary:  Formation of the open complex exposes the template strand to the catalytic center of the RNA polymerase II enzyme. This facilitates formation of the first phosphodiester bond, which marks transcription initiation. As a result of this, the TFIIB basal transcription factor dissociates from the initiation complex.

  • ... HIV-1 Transcription Initiation ...
  • ... Reactome ...
  • ... reactome.
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Pathway: Formation of RNA Pol II elongation complex  from Reactome  [62 molecules]
TFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms.

Summary:  TFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elongation arrest.

  • ... Formation of RNA Pol II elongation complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Formation of RNA Pol II elongation complex 271828. ... contribute to the formation of a processive elongation complex centered around the RNA Pol II complex positioned on the DNA:RNA hybrid. ... This enables the RNA Pol II elongation complex to function. ... is a heterotrimeric protein complex that stimulates the overall rate of elongation.
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Pathway: Vpu mediated degradation of CD4  from Reactome  [74 molecules]
Authored: Matthews, L, 2006-05-15 07:16:46.

Summary:  Authored: Matthews, L, 2006-05-15 07:16:46

  • ... Reactome ...
  • ... reactome.
  • The HIV-1 Vpu protein promotes the degradation of the CD4 receptor by recruiting an SCF like ubiquitination complex that promotes CD4 degradation. ... The SKP1 component of the SCF complex is then recruited to the Vpu–h-βTrCP. ... membrane pore formation and/or interference with TASK-1, an acid-sensitive K+ channel that inhibits ...
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Pathway: Inhibition of TSC complex formation by PKB  from Reactome  [9 molecules]
Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020).

Summary:  Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020). TSC2 function is affected in at least two ways: first, phosphorylation decreases the activity of TSC2; second, phosphorylation destabilizes the TSC2 protein. This destabilization is achieved by disrupting complex formation between TSC1 and TSC2 and inducing ubiquination of the free TSC2 (PMID 12172553). Phosphorylation of complexed TSC2 by PKB induces degradation of both TSC1 and TSC2 through the proteosome pathway (PMID 121676664). Phosphorylation of complexed TSC2 by PKB may therefore result in the dissociation of the TSC1:TSC2 complex (PMID 12423332).

  • Inhibition of TSC complex formation by PKB ...
  • ... Reactome ...
  • ... reactome.
  • Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020). ... complex formation between TSC1 and TSC2 and inducing ubiquination of the free TSC2 (PMID 12172553. ... in the dissociation of the TSC1:TSC2 complex (PMID 12423332).
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Pathway: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks  from Reactome  [9 molecules]
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.

Summary:  Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.

  • Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks ...
  • ... Reactome ...
  • ... of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks ...
  • Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.