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Searched for: REACTOME AND Formation and Maturation of mRNA Transcript [All Organisms, All Data Sources]

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Pathways (158)Molecules (10)
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Pathway: Formation and Maturation of mRNA Transcript  from Reactome  [403 molecules]
Edited: Joshi-Tope, G, 0000-00-00 00:00:00.

Summary:  Edited: Joshi-Tope, G, 0000-00-00 00:00:00

  • ... Formation and Maturation of mRNA Transcript ...
  • ... Reactome ...
  • ... reactome.
  • Before a gene transcript is ready. ... translatable mRNA. ... These comprise capping, splicing out of introns from within the body of the pre-mRNA. ... On the other hand, most mRNA ...
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Pathway: mRNA 3'-end processing  from Reactome  [60 molecules]
The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript.

Summary:  The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence, (ii) the upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues, whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing, and transcription termination in vivo.

  • ... mRNA 3'-end processing ...
  • ... Reactome ...
  • ... reactome.
  • The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. ... For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first cleaved at a particular phosphodiester.
  • ... Formation of mRNA 3' ends in eukaryotes: mechanism ...
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Pathway: Formation of the Editosome  from Reactome  [6 molecules]
Authored: Gopinathrao, G, 2003-12-05 16:34:53.

Summary:  Authored: Gopinathrao, G, 2003-12-05 16:34:53

  • ... Formation of the Editosome ...
  • ... Reactome ...
  • ... reactome.
  • ... deaminase family of enzymes, apoB mRNA editig catalytic polypeptide 1 (APOBEC-1) and a complementing specificity factor (ACF) in addition to the target mRNA.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Cap-dependent Translation Initiation  from Reactome  [153 molecules]
Translation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start codon of an mRNA.

Summary:  Translation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start codon of an mRNA. The basic mechanism for this process can be described as a series of five steps: 1) formation of a pool of free 40S subunits, 2) formation of the ternary complex (Met-tRNAi/eIF2/GTP), and subsequently, the 43S complex (comprising the 40S subunit, Met-tRNAi/eIF2/GTP, eIF3 and eIF1A), 3) activation of the mRNA upon binding of the cap-binding complex eIF4F, and factors eIF4A, eIF4B and eIF4H, with subsequent binding to the 43S complex, 4) ribosomal scanning and start codon recognition, and 5) GTP hydrolysis and joining of the 60S ribosomal subunit.

  • ... of an mRNA. ... The basic mechanism for this process can be described as a series of five steps: 1) formation of a pool of free 40S subunits, 2) formation of the ternary complex (Met-tRNAi/eIF2/GTP.
  • ... Reactome ...
  • ... reactome.
  • ... ) activation of the mRNA upon binding of the cap-binding complex eIF4F, and factors eIF4A, eIF4B and eIF4H. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Centrosome maturation  from Reactome  [89 molecules]
Authored: Matthews, L, 2008-11-11 14:53:40.

Summary:  Authored: Matthews, L, 2008-11-11 14:53:40

  • Centrosome maturation ...
  • ... Reactome ...
  • ... reactome.
  • ... the formation of the mitotic spindle. ... Centrosome maturation is an early event in this process and involves a major reorganization of centrosomal material at the G2/M transition. ... During maturation, centrosomes.
  • ... Use this URL to connect to the web page of this instance in Reactome ...
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Pathway: Translation initiation complex formation  from Reactome  [72 molecules]
The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H.

Summary:  The translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. eIF1A is necessary for the formation of this complex.

  • Translation initiation complex formation ...
  • ... Reactome ...
  • ... reactome.
  • The translation initiation complex forms when the 43S complex binds the mRNA that is associated. ... is necessary for the formation of this complex.
  • ... this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S  from Reactome  [80 molecules]
The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E.

Summary:  The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA.

  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S ...
  • ... Reactome ...
  • ... reactome.
  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent. ... with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation. ... structures near the 5'-end of the mRNA.
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Pathway: Processing of Capped Intronless Pre-mRNA  from Reactome  [52 molecules]
Authored: Marzluff, WF, 2003-08-22 00:29:39.

Summary:  Authored: Marzluff, WF, 2003-08-22 00:29:39

  • Processing of Capped Intronless Pre-mRNA ...
  • ... Reactome ...
  • ... reactome.
  • Co-transcriptional pre-mRNA splicing. ... is required for efficient translation of histone mRNA in vivo and in vitro ...
  • ... Reactome stable. ... Formation of the 3' end of histone mRNA.
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Pathway: Formation of RNA Pol II elongation complex  from Reactome  [62 molecules]
TFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms.

Summary:  TFIIS is a transcription factor involved in different phases of transcription, occurring in a major ubiquitous form and other tissue specific forms. TFIIS stimulates RNA Pol II complex out of elongation arrest.

  • ... Formation of RNA Pol II elongation complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Formation of RNA Pol II elongation complex 271828. ... contribute to the formation of a processive elongation complex centered around the RNA Pol II complex. ... as a platform that coordinates mRNA processing and export (Reviewed by Shilatifard et al. ... in Reactome: http://www. ...reactome.
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Pathway: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)  from Reactome  [9 molecules]
Reviewed: Chao, JA, 2010-05-30.

Summary:  Reviewed: Chao, JA, 2010-05-30

  • Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) ...
  • ... Reactome ...
  • ... reactome.
  • Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) 271828. ... Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation.
  • ... Reactome stable identifier.