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Searched for: REACTOME AND Fanconi Anemia pathway [All Organisms, All Data Sources]

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Pathway: Regulation of the Fanconi anemia pathway  from Reactome  [13 molecules]
The Fanconi anemia DNA repair pathway is negatively regulated by the deubiquitination of FANCD2 an postively regulated by phosphorylation of the FANCD2 and FANCI.

Summary:  The Fanconi anemia DNA repair pathway is negatively regulated by the deubiquitination of FANCD2 an postively regulated by phosphorylation of the FANCD2 and FANCI. The USP1 deubiquitinating enzyme is responsible for FANCD2 deubiquitination and is activated by the WD40-repeat containing UAF1 protein through formation of a stable USP1/UAF1 protein complex (Cohn et al., 2007). ATR and ATM dependent phosphorylation of FANCD2 at T691 and S717 promotes the monoubiquitination of FANCD2 stimulating the FA pathway (Ho et al., 2006). Multiple phosphorylation sites within FANCI are functionally important for inducing monoubiquitination of FANCD2 and thus the activation of the FA pathway (Ishiai et al., 2008) .

  • Regulation of the Fanconi anemia pathway ...
  • ... Reactome ...
  • ... reactome.
  • The Fanconi anemia DNA repair pathway is negatively regulated by the deubiquitination of FANCD2. ... phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway ...
  • ... in the Fanconi anemia pathway and undergoes negative autoregulation ...
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Pathway: Fanconi Anemia pathway  from Reactome  [29 molecules]
Edited: Matthews, L, 2009-05-20 15:51:04.

Summary:  Edited: Matthews, L, 2009-05-20 15:51:04

  • ... Fanconi Anemia pathway ...
  • ... Reactome ...
  • ... reactome.
  • A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway 271828.
  • ... Fanconi anemia (FA) is a genetic disease of genome instability characterized by congenital. ... Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break ...