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Searched for: REACTOME AND E2F mediated regulation of DNA replication [All Organisms, All Data Sources]

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Pathway: E2F mediated regulation of DNA replication  from Reactome  [37 molecules]
Progression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by Rb:E2F pathway.

Summary:  Progression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by Rb:E2F pathway. Rb:E2F pathway plays a key role in gene expression regulation in proliferating and differentiated cells. As a repressor, E2F remains bound to Rb; it can activate the expression of S-phase genes involved in DNA replication after the phosphorylation of Rb.

  • ... E2F mediated regulation of DNA replication ...
  • ... Reactome ...
  • ... reactome.
  • ... E2F mediated regulation of DNA replication 271828.
  • Emerging roles for E2F: beyond the G1/S transition and DNA replication. ... regulation in proliferating and differentiated cells. ... As a repressor, E2F remains bound to Rb; it can activate the expression of S-phase genes involved in DNA replication after the phosphorylation ...
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Pathway: CDC6 association with the ORC:origin complex  from Reactome  [13 molecules]
Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39.

Summary:  Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39

  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
  • Multistep regulation of DNA replication by Cdk phosphorylation. ... of DNA replication initiation in both yeasts and human cells, but its mechanism of action differs. ...) indicate that the normal function of Cdc6 protein is required to restrict DNA replication to once per.
  • ATPase switches controlling DNA replication initiation.
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Pathway: G1/S-Specific Transcription  from Reactome  [4 molecules]
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle.

Summary:  The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D?CDK complexes releases pRb from E2F inducing E2F-targeted genes such as cyclin E.

  • ... Reactome ...
  • ... reactome.
  • The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. ... E2F activity. ... from E2F inducing E2F-targeted genes such as cyclin E.
  • ... Reactome stable identifier.
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Pathway: SCF(Skp2)-mediated degradation of p27/p21  from Reactome  [78 molecules]
Reviewed: Coqueret, O, 2006-10-06 08:59:06.

Summary:  Reviewed: Coqueret, O, 2006-10-06 08:59:06

  • SCF(Skp2)-mediated degradation of p27/p21 ...
  • ... Reactome ...
  • ... reactome.
  • SCF(Skp2)-mediated degradation of p27/p21 271828. ... E/A:Cdk2- mediated phosphorylated at Thr 187 of p27 (Montagnoli et al. ... The mechanism of SCF(Skp2)-mediated degradation of p21 is similar to that of p27 in terms of its requirements. ... of phosphorylation, although with less efficiency (Bornstein et al. ... SCF(Skp2)-mediated degradation ...
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Pathway: Transcriptional activation of p53 responsive genes  from Reactome  [2 molecules]
p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993).

Summary:  p53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration and cell cycle arrest at the G1/S transition. Mice with a homozygous deletion of p21 gene are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995).

  • ... Reactome ...
  • ... reactome. ... complexes that mediate G1/S progression, resulting in lack of phosphorylation of Rb, E2F sequestration. ... are deficient in their ability to undergo a G1/S arrest in response to DNA damage (Deng et al, 1995). ... in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: Cyclin D associated events in G1  from Reactome  [52 molecules]
Three D-type cyclins are essential for progression from G1 to S-phase.

Summary:  Three D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and CDK4/6 is promoted by the proteins, p21(CIP1/WAF1) and p27(KIP1). The cyclin-dependent kinases are then activated due to phosphorylation by CAK. The cyclin dependent kinases phosphorylate the RB1 protein and RB1-related proteins p107 (RBL1) and p130 (RBL2). Phosphorylation of RB1 leads to release of activating E2F transcription factors (E2F1, E2F2 and E2F3). After repressor E2Fs (E2F4 and E2F5) dissociate from phosphorylated RBL1 and RBL2, activating E2Fs bind to E2F promoter sites, stimulating transcription of cell cycle genes, which then results in proper G1/S transition. The binding and sequestration of p27Kip may also contribute to the activation of CDK2 cyclin E/CDK2 cyclin A complexes at the G1/S transition (Yew et al., 2001).

  • ... Reactome ...
  • ... reactome.
  • ... Phosphorylation of RB1 leads to release of activating E2F. ... phosphorylated RBL1 and RBL2, activating E2Fs bind to E2F promoter sites, stimulating transcription.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: G1 Phase  from Reactome  [52 molecules]
Early cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6.

Summary:  Early cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphorylated promotes cell cycle progression by releasing E2F transcription factors that transactivate several important genes for later cell cycle events. The formation of Cyclin D - Cdk4/6 complexes is promoted by two proteins, p21Cip1/Waf1 and p27kip1, and their activity can be inhibited by the binding of several small CDK-inhibitory proteins (CKIs): p15INK4B, p16INK4A, p18INK4C and p19INK4D.

  • ... Reactome ...
  • ... reactome.
  • ... ) protein, which when phosphorylated promotes cell cycle progression by releasing E2F transcription. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance ...
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Pathway: G0 and Early G1  from Reactome  [36 molecules]
Authored: Orlic-Milacic, Marija, 2011-08-26.

Summary:  Authored: Orlic-Milacic, Marija, 2011-08-26

  • ... Reactome ...
  • ... reactome.
  • ... transcription of E2F target genes. ... Both p130 (RBL2) and p107 (RBL1) repress transcription of E2F targets through. ... in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable ...