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Searched for: REACTOME AND Destabilization of mRNA by KSRP [All Organisms, All Data Sources]

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Pathway: Destabilization of mRNA by KSRP  from Reactome  [28 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... Destabilization of mRNA by KSRP ...
  • ... Reactome ...
  • ... reactome.
  • ... KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. ... KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. ... The phosphorylation inhibits the ability of KSRP to destabilize mRNA. ... KSRP phosphorylated ...
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Pathway: Destabilization of mRNA by Tristetraprolin (TTP)  from Reactome  [26 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... Destabilization of mRNA by Tristetraprolin (TTP) ...
  • ... Reactome ...
  • ... reactome.
  • ... Destabilization of mRNA by Tristetraprolin. ... with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound.
  • Control of mRNA decay by phosphorylation. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)  from Reactome  [34 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) ...
  • ... Reactome ...
  • ... reactome.
  • ... Destabilization of mRNA.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME 271828 ...
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Pathway: Destabilization of mRNA by AUF1 (hnRNP D0)  from Reactome  [78 molecules]
Edited: May, B, 2009-12-29.

Summary:  Edited: May, B, 2009-12-29

  • ... Destabilization of mRNA by AUF1 (hnRNP D0) ...
  • ... Reactome ...
  • ... reactome.
  • ... Destabilization of mRNA by AUF1 (hnRNP D0) 271828. ... protein, Hsp, Hsc70, Hsp27, NSEP-1, NSAP-1, and IMP-2 which target the mRNA and AUF1 for degradation. ... the bound mRNA is degraded. ... Inhibition of ubiquitin addition to AUF1 blocks mRNA degradation. ... The mechanism by which ubiquitin-dependent proteolysis is coupled to mRNA degradation is unknown.
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Pathway: Inhibition of TSC complex formation by PKB  from Reactome  [9 molecules]
Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020).

Summary:  Phosphorylation of TSC2 by PKB disrupts TSC1/TSC2 heterodimer formation (PMID 15314020). TSC2 function is affected in at least two ways: first, phosphorylation decreases the activity of TSC2; second, phosphorylation destabilizes the TSC2 protein. This destabilization is achieved by disrupting complex formation between TSC1 and TSC2 and inducing ubiquination of the free TSC2 (PMID 12172553). Phosphorylation of complexed TSC2 by PKB induces degradation of both TSC1 and TSC2 through the proteosome pathway (PMID 121676664). Phosphorylation of complexed TSC2 by PKB may therefore result in the dissociation of the TSC1:TSC2 complex (PMID 12423332).

  • ... Reactome ...
  • ... reactome. ... This destabilization is achieved by disrupting. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Permeabilization of mitochondria
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • ... Reactome ...
  • ... reactome.
  • ... and oligomerization of Bax and Bak result in the destabilization of the outer mitochondrial membrane.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
  • ... Use this URL to connect to the web page of this instance ...
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Pathway: Intrinsic Pathway for Apoptosis  from Reactome  [65 molecules]
The intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stresses in the endoplasmic reticulum and death receptor stimulation.

Summary:  The intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stresses in the endoplasmic reticulum and death receptor stimulation. Following the reception of stress signals, proapoptotic BCL-2 family proteins are activated and subsequently interact with and inactivate antiapoptotic BCL-2 proteins. This interaction leads to the destabilization of the mitochondrial membrane and release of apoptotic factors. These factors induce the caspase proteolytic cascade, chromatin condensation, and DNA fragmentation, ultimately leading to cell death. The key players in the Intrinsic pathway are the Bcl-2 family of proteins that are critical death regulators residing immediately upstream of mitochondria. The Bcl-2 family consists of both anti- and proapoptotic members that possess conserved alpha-helices with sequence conservation clustered in BCL-2 Homology (BH) domains. Proapoptotic members are organized as follows:

  • ... Reactome ...
  • ... reactome.
  • ... This interaction leads to the destabilization of the mitochondrial membrane and release.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: The NLRP3 inflammasome  from Reactome  [34 molecules]
Reviewed: Rittinger, K, 2011-06-06.

Summary:  Reviewed: Rittinger, K, 2011-06-06

  • ... Reactome ...
  • ... reactome.
  • ... the NALP3 inflammasome through phagosomal destabilization ...
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable ...