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Searched for: REACTOME AND Cyclin D associated events in G1 [All Organisms, All Data Sources]

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Pathways (45)Molecules (92)
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Pathway: Cyclin D associated events in G1  from Reactome  [52 molecules]
Three D-type cyclins are essential for progression from G1 to S-phase.

Summary:  Three D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and CDK4/6 is promoted by the proteins, p21(CIP1/WAF1) and p27(KIP1). The cyclin-dependent kinases are then activated due to phosphorylation by CAK. The cyclin dependent kinases phosphorylate the RB1 protein and RB1-related proteins p107 (RBL1) and p130 (RBL2). Phosphorylation of RB1 leads to release of activating E2F transcription factors (E2F1, E2F2 and E2F3). After repressor E2Fs (E2F4 and E2F5) dissociate from phosphorylated RBL1 and RBL2, activating E2Fs bind to E2F promoter sites, stimulating transcription of cell cycle genes, which then results in proper G1/S transition. The binding and sequestration of p27Kip may also contribute to the activation of CDK2 cyclin E/CDK2 cyclin A complexes at the G1/S transition (Yew et al., 2001).

  • ... Cyclin D associated events in G1 ...
  • ... Reactome ...
  • ... reactome.
  • Three D-type cyclins are essential for progression from G1 to S-phase. ... These D cyclins bind to and activate both CDK4 and CDK6. ... The formation of all possible complexes between the D-type cyclins and CDK4/6 is promoted by the proteins, p21(CIP1/WAF1) and p27(KIP1). ... The cyclin-depen [Cont. ...] kinases are then activated due ...
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Pathway: Cyclin E associated events during G1/S transition  from Reactome  [116 molecules]
The transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes.

Summary:  The transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphorylation keeps the Cdk2 inactive. In yeast this control is called the cell size checkpoint control. The dephosphorylation of the Cdk2 by Cdc25A activates the Cdk2, and is coordinated with the cells reaching the proper size, and with the DNA synthesis machinery being ready. The Cdk2 then phosphorylates G1/S specific proteins, including proteins required for DNA replication initiation. The beginning of S-phase is marked by the first nucleotide being laid down on the primer during DNA replication at the early-firing origins

  • ... Cyclin E associated events during G1/S transition ...
  • ... Reactome ...
  • ... reactome.
  • The transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. ... As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. ... replication at the early-firing origins ...
  • ... Reactome stable identifier.
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Pathway: G1 Phase  from Reactome  [52 molecules]
Early cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6.

Summary:  Early cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphorylated promotes cell cycle progression by releasing E2F transcription factors that transactivate several important genes for later cell cycle events. The formation of Cyclin D - Cdk4/6 complexes is promoted by two proteins, p21Cip1/Waf1 and p27kip1, and their activity can be inhibited by the binding of several small CDK-inhibitory proteins (CKIs): p15INK4B, p16INK4A, p18INK4C and p19INK4D.

  • ... G1 Phase ...
  • ... Reactome ...
  • ... reactome.
  • Early cell cycle progression in G1 is under the control of the D. ... factors that transactivate several important genes for later cell cycle events. ... The formation of Cyclin D - Cdk4/6 complexes is promoted by two proteins, p21Cip1/Waf1 and p27kip1, and their activity. ... Database identifier. ... Use this URL to connect to the web page of this instance in Reactome: http ...
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Pathway: Cell Cycle, Mitotic  from Reactome  [603 molecules]
Authored: O'Connell, M, Walworth, N, Bosco, G, 2005-01-01 14:12:30.

Summary:  Authored: O'Connell, M, Walworth, N, Bosco, G, 2005-01-01 14:12:30

  • ... gap-phases separate these major cell cycle events: G1 between mitosis and S-phase, and G2 between S.
  • ... Reactome ...
  • ... reactome.
  • Reviewed: MacPherson, D, 2011-08-25 ...
  • Edited: Matthews, L. ... into daughter cells are controlled by a series of events collectively known as the cell cycle. ... DNA. ... functions of individual tissues. ...brA family of protein serine/threonine kinases known as the cyclin-depen [Cont. ...] ...
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Pathway: Cyclin A:Cdk2-associated events at S phase entry  from Reactome  [131 molecules]
Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27.

Summary:  Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. After forming in the cytoplasm, the Cyclin A:Cdk2 complexes are translocated to the nucleus (Jackman et al.,2002). Prior to S phase entry, the activity of Cyclin A:Cdk2 complexes is negatively regulated through Tyr 15 phosphorylation of Cdk2 (Gu et al., 1995) and also by the association of the cyclin kinase inhibitors (CKIs), p27 and p21. Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK2 kinase activity (Aprelikova et al., 1995). The entry into S phase is promoted by the removal of inhibitory Tyr 15 phosphates from the Cdk2 subunit of Cyclin A:Cdk2 complex by the Cdc25 phosphatases (Blomberg and Hoffmann, 1999) and by SCF(Skp2)-mediated degradation of p27/p21 (see Ganoth et al., 2001). While Cdk2 is thought to play a primary role in regulating entry into S phase, recent evidence indicates that Cdk1 is equally capable of promoting entry into S phase and the initiation of DNA replication (see Bashir and Pagano, 2005). Thus, Cdk1 complexes may also play a significant role at this point in the cell cycle.

  • ... Cyclin A:Cdk2-associated events at S phase entry ...
  • ... Reactome ...
  • ... reactome.
  • ... Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. ... During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. ... After forming in the cytoplasm, the Cyclin A:Cdk2 complexes are translocated ...
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Pathway: Cyclin A/B1 associated events during G2/M transition  from Reactome  [53 molecules]
Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases.

Summary:  Cell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the phosphorylation of nuclear lamins and histones (reviewed in Sefton, 2001).

  • ... Cyclin A/B1 associated events during G2/M transition ...
  • ... Reactome ...
  • ... reactome.
  • Cell cycle progression is regulated by cyclin-depen [Cont. ...] protein kinases at both the G1/S and the G2/M transitions by cyclin-depen [Cont. ...] protein kinases.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance ...
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Pathway: Ubiquitin-dependent degradation of Cyclin D1  from Reactome  [75 molecules]
After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner.

Summary:  After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is a topic still under investigation, although both the kinases are required for normal cell cycle progression.

  • Ubiquitin-dependent degradation of Cyclin D1 ...
  • ... Reactome ...
  • ... reactome.
  • After the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled. ...pDestruction of the D type cyclins accompanies the end of the G1 phase, and the E type cyclins are involved in transition of the cell from G1 to S phase.
  • ... Reactome stable ...
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Pathway: APC/C-mediated degradation of cell cycle proteins  from Reactome  [124 molecules]
The Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin.

Summary:  The Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This complex is also active in interphase insuring the appropriate length of the G1 phase (reviewed in Peters, 2002). The APC/C contains at least 12 subunits and functions as an ubiquitin-protein ligase (E3) promoting the multiubiquitination of its target proteins (see Gieffers et al., 2001).

  • ... are recognized by a motif known as the destruction box (D box) include Cyclin A, Nek2, Securin. ... of Cyclin A at the end of G1. ... This stabilization, in turn, promotes the phosphorylation of Cdh1 and its. ...APC/C-mediated degradation of cell cycle proteins ...
  • ... Reactome ...
  • ... reactome. ... and securin. ... This complex is also active in interphase insuring the appropriate length of the G1 phase. ... is highly periodic during the cell cycle and is controlled by a combination of regulatory events ...
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Pathway: G0 and Early G1  from Reactome  [36 molecules]
Authored: Orlic-Milacic, Marija, 2011-08-26.

Summary:  Authored: Orlic-Milacic, Marija, 2011-08-26

  • ... peaking in late G1 and S phase. ... Although p107 (RBL1) is phosphorylated by cyclin D assocaited kinases. ...G0 and Early G1 ...
  • ... Reactome ...
  • ... reactome.
  • G0 and Early G1 ...
  • Authored: Orlic-Milacic, Marija, 2011-08-26 ...
  • Reviewed: MacPherson, D, 2011-08-25 ...
  • In G0 and early G1 in quiescent cells, p130 (RBL2) bound. ... conserved DREAM complex, that represses transcription of cell cycle genes. ... During early G1 phase ...
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Pathway: G1/S-Specific Transcription  from Reactome  [4 molecules]
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle.

Summary:  The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D?CDK complexes releases pRb from E2F inducing E2F-targeted genes such as cyclin E.

  • ... Phosphorylation of pRb by cyclin D?CDK complexes releases pRb from E2F inducing E2F-targeted genes such as cyclin E.
  • ... Reactome stable identifier. ...G1/S-Specific Transcription ...
  • ... Reactome ...
  • ... reactome.
  • ... of transcription factors regulate the transition from the G1 to the S phase in the cell cycle.