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Searched for: REACTOME AND Assembly of the pre-replicative complex [All Organisms, All Data Sources]

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Pathways (71)Molecules (4)
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Pathway: Assembly of the pre-replicative complex  from Reactome  [97 molecules]
Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39.

Summary:  Authored: Davey, MJ, O'Donnell, M, Tye, BK, 2006-03-17 16:01:39

  • ... Assembly of the pre-replicative complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Assembly of the pre-replicative complex 271828. ... in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M. ... of the proteins in the pre-replicative complex. ... The ORC subunits Orc1, Orc4 and Orc5 are homologous. ... cerevisiae/i, pre-replicative complexes are assembled from late M to G1 ...
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Pathway: Activation of the pre-replicative complex  from Reactome  [55 molecules]
In S.

Summary:  In S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding by Orc1 is unaffected by the association of ORC with origin DNA (ARS) sequences, but ATP hydrolysis is ARS-dependent, being suppressed by associated double-stranded DNA and stimulated by associated single-stranded DNA. These data are consistent with the hypothesis that ORC functions as an ATPase switch, hydrolyzing bound ATP and changing state as DNA unwinds at the origin immediately before replication. It is attractive to speculate that ORC likewise functions as a switch as human pre-replicative complexes are activated, but human Orc proteins are not well enough characterized to allow the model to be critically tested. mRNAs encoding human orthologs of all six Orc proteins have been cloned, and ATP-binding amino acid sequence motifs have been identified in Orc1, Orc4, and Orc5. Interactions among proteins expressed from the cloned genes have been characterized, but the ATP-binding and hydrolyzing properties of these proteins and complexes of them have not been determined.

  • Activation of the pre-replicative complex ...
  • ... Reactome ...
  • ... reactome.
  • Activation of the pre-replicative complex 271828. ... Assembly of the human origin recognition complex.
  • ... origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.
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Pathway: CDT1 association with the CDC6:ORC:origin complex  from Reactome  [82 molecules]
Initiation protein Cdt1 was first identified in X.

Summary:  Initiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. melanogaster, humans, and S. cerevisiae. Genetic studies in S. pombe have shown that binding of Cdc6 to chromatin requires the prior binding of Cdc18, the S. pombe homolog of Cdc6. In humans, the function of CDT1 is regulated during the cell cycle by its tight association with an inhibitory factor, geminin.

  • XCDT1 is required for the assembly of pre-replicative complexes in Xenopus. ...CDT1 association with the CDC6:ORC:origin complex ...
  • ... Reactome ...
  • ... reactome. ... complex ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks  from Reactome  [9 molecules]
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.

Summary:  Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.

  • ... Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks ...
  • ... Reactome ...
  • ... reactome.
  • ... Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks involves the formation of RAD50:MRE11 complex, association of RAD50:MRE11 complex with NBS1 through MRE11 and association of the MRN with sites of DSB.
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Pathway: snRNP Assembly  from Reactome  [76 molecules]
Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs.

Summary:  Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA differs from the other snRNAs; it binds seven Sm-like proteins and its assembly does not involve a cytoplasmic phase. The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. The assembly of the snRNA:Sm-core is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and binds the RNA-binding Sm proteins.

  • ... snRNP Assembly ...
  • ... Reactome ...
  • ... reactome.
  • ... proteins and its assembly does not involve a cytoplasmic phase. ... The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm ...
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Pathway: Formation of incision complex in GG-NER  from Reactome  [31 molecules]
Authored: Joshi-Tope, G, 2003-07-14 15:01:00.

Summary:  Authored: Joshi-Tope, G, 2003-07-14 15:01:00

  • Formation of incision complex in GG-NER ...
  • ... Reactome ...
  • ... reactome.
  • Binding of XPC complex to the damaged site on the DNA. ... types of DNA damage. ... Binding of RPA, or Replicative protein A, a heterotrimer, initiates the formation of incision complex. ... This includes a serial assembly of the rest of the NER machinery consisting ...
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Pathway: Presynaptic phase of homologous DNA pairing and strand exchange  from Reactome  [18 molecules]
The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

Summary:  The presynaptic phase of homologous DNA pairing and strand exchange begins with the displacement of RPA from ssDNA, followed by the association of RAD51 with BRCA2, formation of RAD52 heptameric ring structure complexes on ssDNA, association of RAD52 with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.

  • ... with the RPA complex, association of RAD52 with ssDNA at resected ends of double-strand break and assembly of the RAD51-ssDNA nucleoprotein complex.
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier. ...Presynaptic phase of homologous DNA pairing and strand exchange ...
  • ... Reactome ...
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Pathway: RNA Polymerase I Promoter Opening  from Reactome  [15 molecules]
The activity of the upstream binding factor (UBF-1) plays an important role in the regulation of rRNA synthesis.

Summary:  The activity of the upstream binding factor (UBF-1) plays an important role in the regulation of rRNA synthesis. Studies reveal that phosphorylation of UBF-1 is required for its interaction with the RNA polymerase I complex, suggesting that phosphorylation of UBF-1 bound to the rDNA promoter during promoter opening modulates the assembly of the transcription initiation complex.

  • ... complex, suggesting that phosphorylation of UBF-1 bound to the rDNA promoter during promoter opening modulates the assembly of the transcription initiation complex.
  • ... Reactome ...
  • ... reactome.
  • ... of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable identifier.
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Pathway: Regulation of cytoskeletal remodeling and cell spreading by IPP complex components  from Reactome  [13 molecules]
Authored: Matthews, L, 2009-10-12.

Summary:  Authored: Matthews, L, 2009-10-12

  • Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ...
  • ... Reactome. ... Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ...
  • Authored: Matthews. ...: Matthews, L, 2009-11-10 ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...
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Pathway: Localization of the PINCH-ILK-PARVIN complex to focal adhesions  from Reactome  [6 molecules]
Authored: Matthews, L, 2009-10-12.

Summary:  Authored: Matthews, L, 2009-10-12

  • Localization of the PINCH-ILK-PARVIN complex to focal adhesions ...
  • ... Reactome ...
  • ... Assembly of the PINCH-ILK-CH-ILKBP complex precedes. ...-ILK-PARVIN complex to focal adhesions ...
  • Authored: Matthews, L, 2009-10-12 ...
  • The interactions. ...“parvin complex components likely participate in mediating its localization (reviewed in Wu, 2004).
  • Edited: Matthews, L, 2009-11-10 ...
  • ... Reactome stable ...