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Searched for: REACTOME AND Apoptosis [All Organisms, All Data Sources]

Your search has found 52 relevant records:

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Pathways (52)Molecules (1)
Showing Results 1 - 10 of 52  | Next 10
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Pathway: TRAIL signaling  from Reactome  [11 molecules]
Authored: Gillespie, ME, 2004-08-31 03:31:31.

Summary:  Authored: Gillespie, ME, 2004-08-31 03:31:31

  • ... TRAIL and apoptosis induction by TNF-family death receptors ...
  • ... Reactome stable.
  • ... Reactome ...
  • ... reactome.
  • Tumor necrosis factor-related apoptosis-inducing. ... of apoptosis induction pathways all work through protein interactions mediated by the intracellular. ... apoptosis through its interaction with the Fas-associated death domain protein (FADD).
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Pathway: Regulation of Apoptosis  from Reactome  [92 molecules]
Reviewed: Chang, E, 2008-05-21 00:05:41.

Summary:  Reviewed: Chang, E, 2008-05-21 00:05:41

  • Regulation of Apoptosis ...
  • ... Reactome ...
  • ... reactome.
  • A regulated balance between cell survival and apoptosis is essential for normal. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
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Pathway: Cell death signalling via NRAGE, NRIF and NADE  from Reactome  [47 molecules]
p75NTR is a key regulator of neuronal apoptosis, both during development and after injury.

Summary:  p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. TRKA signalling protects neurons from apoptosis. The molecular mechanisms involved in p75NTR-apoptosis are not well understood. The death signalling requires activation of c-JUN N-terminal Kinase (JNK), as well as transcriptional events. JNK activation appears to involve the receptor interacting proteins TRAF6, NRAGE, and Rac. The transcription events are thought to be regulated by another p75-interacting protein, NRIF. Two other p75-interacting proteins, NADE and Necdin, have been implicated in apoptosis, but their role is less clear.

  • ... Reactome ...
  • ... reactome.
  • ... p75NTR is a key regulator of neuronal apoptosis, both during development and after injury. ... Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ... ProNGF is at least 10 times more potent than mature NGF in inducing apoptosis. ... TRKA signalling protects neurons from apoptosis. ... The molecular mechanisms involved in p75NTR-apoptosis are not well ...
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Pathway: Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization  from Reactome  [4 molecules]
Authored: Matthews, L, 2006-05-15 07:16:46.

Summary:  Authored: Matthews, L, 2006-05-15 07:16:46

  • Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization ...
  • ... Reactome ...
  • ... reactome.
  • In one model of Vpr mediated induction of apoptosis, Vpr acts directly. ... membranes resulting in the release of cytochrome c and apoptosis-inducing factors.
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Pathway: Influenza Virus Induced Apoptosis  from Reactome  [5 molecules]
Influenza A virus induces apoptosis in a variety of ways including activation of host TGF-beta by expression of viral NA, M1 and M2 proteins, and by the binding of viral PB1-F2 to host mitochondrial adenine nucleotide translocator 3 (ANT3).

Summary:  Influenza A virus induces apoptosis in a variety of ways including activation of host TGF-beta by expression of viral NA, M1 and M2 proteins, and by the binding of viral PB1-F2 to host mitochondrial adenine nucleotide translocator 3 (ANT3).

  • Influenza Virus Induced Apoptosis ...
  • ... Reactome ...
  • ... reactome.
  • Influenza A virus induces apoptosis in a variety of ways including activation of host TGF-beta by expression of viral.
  • Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells ...
  • ... Reactome stable identifier.
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Pathway: Role of DCC in regulating apoptosis  from Reactome  [17 molecules]
Authored: Garapati, P V, 2008-07-16 14:42:16.

Summary:  Authored: Garapati, P V, 2008-07-16 14:42:16

  • Role of DCC in regulating apoptosis ...
  • ... Reactome ...
  • ... reactome.
  • ... Recent reports have shown that UNC5 receptors similarly induce apoptosis in the absence. ... They create cellular states of dependence on their respective ligands by either inducing apoptosis when unoccupied by the ligand, or inhibiting apoptosis in the presence of the ligand.
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Pathway: Extrinsic Pathway for Apoptosis  from Reactome  [29 molecules]
Authored: Gillespie, ME, 2004-08-10 16:59:18.

Summary:  Authored: Gillespie, ME, 2004-08-10 16:59:18

  • Extrinsic Pathway for Apoptosis ...
  • ... Reactome ...
  • ... reactome.
  • ... , DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL).
  • ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ...
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Pathway: Apoptosis  from Reactome  [250 molecules]
Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis.

Summary:  Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

  • ... Apoptosis ...
  • ... Reactome ...
  • ... reactome.
  • ... Apoptosis is a distinct form of cell death that is functionally. ..., dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. ... In 1972 Kerr et al introduced the concept of apoptosis. ... BRThe two principal pathways of apoptosis are (1) the Bcl-2 inhibitable or intrinsic pathway ...
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Pathway: Release of apoptotic factors from the mitochondria  from Reactome  [2 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • ... Reactome ...
  • ... reactome. ... the mitochondria promote apoptosis through several different mechanisms. ... Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Activation of PUMA and translocation to mitochondria  from Reactome  [5 molecules]
Puma is transactivated in a p53-dependent manner and by E2F1.

Summary:  Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.

  • ... Reactome ...
  • ... reactome.
  • Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis 271828.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME ...