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Searched for: REACTOME AND Activation of the pre-replicative complex [All Organisms, All Data Sources]

Your search has found 310 relevant records:

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Pathways (310)Molecules (1)
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Pathway: Activation of the pre-replicative complex  from Reactome  [55 molecules]
In S.

Summary:  In S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding by Orc1 is unaffected by the association of ORC with origin DNA (ARS) sequences, but ATP hydrolysis is ARS-dependent, being suppressed by associated double-stranded DNA and stimulated by associated single-stranded DNA. These data are consistent with the hypothesis that ORC functions as an ATPase switch, hydrolyzing bound ATP and changing state as DNA unwinds at the origin immediately before replication. It is attractive to speculate that ORC likewise functions as a switch as human pre-replicative complexes are activated, but human Orc proteins are not well enough characterized to allow the model to be critically tested. mRNAs encoding human orthologs of all six Orc proteins have been cloned, and ATP-binding amino acid sequence motifs have been identified in Orc1, Orc4, and Orc5. Interactions among proteins expressed from the cloned genes have been characterized, but the ATP-binding and hydrolyzing properties of these proteins and complexes of them have not been determined.

  • ... Activation of the pre-replicative complex ...
  • ... Reactome ...
  • ... reactome.
  • ... Activation of the pre-replicative complex 271828. ... origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.
  • Regulation of origin recognition complex conformation and ATPase ...
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Pathway: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation  from Reactome  [127 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation ...
  • ... Reactome 271828. ... induction of NFkB and MAP kinases upon TLR7/8 or 9 activation ...
  • TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. ... TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • ... Reactome stable identifier ...
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Pathway: Cap-dependent Translation Initiation  from Reactome  [153 molecules]
Translation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start codon of an mRNA.

Summary:  Translation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start codon of an mRNA. The basic mechanism for this process can be described as a series of five steps: 1) formation of a pool of free 40S subunits, 2) formation of the ternary complex (Met-tRNAi/eIF2/GTP), and subsequently, the 43S complex (comprising the 40S subunit, Met-tRNAi/eIF2/GTP, eIF3 and eIF1A), 3) activation of the mRNA upon binding of the cap-binding complex eIF4F, and factors eIF4A, eIF4B and eIF4H, with subsequent binding to the 43S complex, 4) ribosomal scanning and start codon recognition, and 5) GTP hydrolysis and joining of the 60S ribosomal subunit.

  • ... of a pool of free 40S subunits, 2) formation of the ternary complex (Met-tRNAi/eIF2/GTP), and subsequently, the 43S complex (comprising the 40S subunit, Met-tRNAi/eIF2/GTP, eIF3 and eIF1A), 3) activation of the mRNA upon binding of the cap-binding complex eIF4F, and factors eIF4A, eIF4B and eIF4H.
  • ... Reactome ...
  • ... reactome.
  • ... initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits ...
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Pathway: IKK complex recruitment mediated by RIP1  from Reactome  [20 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • IKK complex recruitment mediated by RIP1 ...
  • ... Reactome ...
  • ... reactome.
  • IKK complex recruitment mediated by RIP1 271828. ... activation ...
  • ... Reactome stable identifier. ... Use this URL to connect to the web page.
  • Receptor-interacting protein 1 (RIP1) mediates the activation of proinflammatory cytokines via intermediate induction of IKK complex in NFkB pathways (Ea et al.
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Pathway: Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex  from Reactome  [15 molecules]
DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state.

Summary:  DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2 activity is regulated by a balance between the phosphorylation and dephosphorylation by the Wee1/Myt1 kinase and Cdc25 phosphatase. Inactivation of the Cyclin B:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity.

  • Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex ...
  • ... Reactome ...
  • ... inactivation of Cyclin B:Cdk1 complex ...
  • DNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15. ...:Cdc2 complex likely involves both inactivation of Cdc25 and/or stimulation of Wee1/Myt1 kinase activity.
  • Authored: Matthews, L, 2003-08-05 01:10:00 ...
  • ... Reactome stable identifier ...
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Pathway: Activation of BMF and translocation to mitochondria  from Reactome  [6 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • ... Activation of BMF and translocation to mitochondria ...
  • ... Reactome ...
  • ... reactome.
  • ... Activation of BMF and translocation. ... to the myosin V motor complex through its interaction with DLC2.
  • ... Reactome stable identifier. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
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Pathway: Alternative complement activation  from Reactome  [17 molecules]
Reviewed: D'Eustachio, P, 2006-07-03 21:35:13.

Summary:  Reviewed: D'Eustachio, P, 2006-07-03 21:35:13

  • Alternative complement activation ...
  • ... Reactome ...
  • ... reactome.
  • ... participating in alternative pathway activation are C3 (and C3b), the factors B, D, and properdin. ... In the first place, alternative pathway activation is a positive feedback mechanism to increase C3b. ... surface leading to cleavage of C3. ... Finally, a C3bBb3b complex forms and this is a C5 convertase.
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Pathway: Viral dsRNA:TLR3:TRIF Complex Activates RIP1  from Reactome  [26 molecules]
Edited: Shamovsky, V, 2009-12-16.

Summary:  Edited: Shamovsky, V, 2009-12-16

  • Viral dsRNA:TLR3:TRIF Complex Activates RIP1 ...
  • ... Reactome ...
  • ... reactome.
  • Viral dsRNA:TLR3:TRIF Complex Activates RIP1. ... regulatory factor 3 activation ...
  • ... Reactome stable identifier. ...-interacting protein 1 (RIP1) mediates the activation of interferon-alpha/beta via intermediate activation of IKK/TBK1 or NFkB pathways.
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Pathway: TRAF6 mediated induction of TAK1 complex  from Reactome  [28 molecules]
Edited: Shamovsky, V, 2010-11-15.

Summary:  Edited: Shamovsky, V, 2010-11-15

  • TRAF6 mediated induction of TAK1 complex ...
  • ... Reactome ...
  • ... reactome.
  • TRAF6 mediated induction of TAK1 complex 271828. ... Optimal activation of the IKK complex was achieved using ubiquitin polymers containing both K48. ... receptors of TAB2 or TAB3 (TAK1 binding protein 2 and 3), which stimulates phosphorylation and activation. ... to the nucleus. ... Also TAK1 mediates JNK and p38 MAP kinases activation by phosphorylating MKK4/7 ...
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Pathway: TRAF6 mediated NF-kB activation  from Reactome  [25 molecules]
The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1.

Summary:  The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in Tool like receptor (TLR) mediated cytokine production, the involvement of these molecules in the regulation of type I IFN induction mediated by RIG-I/MDA5 pathway is largely unknown. According to the study done by Yoshida et al RIG-I/IPS-1 pathway requires TRAF6 and MAP3K, MEKK1 to activate NF-kB and MAP Kinases for optimal induction of type I IFNs.

  • TRAF6 mediated NF-kB activation ...
  • ... Reactome ...
  • ... reactome.
  • The TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.