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Searched for: REACTOME AND Activation of DNA fragmentation factor [All Organisms, All Data Sources]

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Pathways (310)Molecules (1)
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Pathway: Activation of DNA fragmentation factor  from Reactome  [25 molecules]
Authored: Matthews, L, 2008-01-29 12:03:24.

Summary:  Authored: Matthews, L, 2008-01-29 12:03:24

  • ... Activation of DNA fragmentation factor ...
  • ... Reactome ...
  • ... reactome.
  • ... DNA. ... nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed in Widlak.
  • Subunit structures and stoichiometries of human DNA fragmentation factor proteins ...
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Pathway: Activation of ATR in response to replication stress  from Reactome  [61 molecules]
Authored: Borowiec, JA, 2006-02-25 17:40:15.

Summary:  Authored: Borowiec, JA, 2006-02-25 17:40:15

  • ... Activation of ATR in response to replication stress ...
  • ... Reactome ...
  • ... reactome.
  • ... Activation of ATR in response.
  • Genotoxic stress caused by DNA damage or stalled replication forks can lead. ... checkpoint factors that halt or slow cell cycle progression. ... Among the pathways affected are DNA replication by reduction of replication origin firing, and mitosis by inhibiting activation of cyclin ...
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Pathway: Apoptotic factor-mediated response  from Reactome  [22 molecules]
In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways.

Summary:  In response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome formation, AIF and endonuclease G function in caspase independent apoptotic nuclear DNA damage. Smac/DIABLO and HtrA2/OMI both promote caspase activation and caspase-independent cytotoxicity (Saelens et al., 2004).

  • Apoptotic factor-mediated response ...
  • ... Reactome ...
  • ... reactome.
  • ... and endonuclease G function in caspase independent apoptotic nuclear DNA damage. ... Smac/DIABLO and HtrA2/OMI both promote caspase activation and caspase-independent cytotoxicity (Saelens et al. ... of this instance in Reactome: http://www. ...reactome.
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Pathway: p53-Independent DNA Damage Response  from Reactome  [78 molecules]
In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2.

Summary:  In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. The phosphorylation of Cdc25A at ser-123, in response to DNA damage from ionizing radiation is a signal for ubiquitination and subsequent degradation of Cdc25A. The destruction of Cdc25A prevents the normal G1/S transition. Cdc25A is required for the activation of the Cyclin E:Cdk2 complexes via dephosphorylation.

  • ... p53-Independent DNA Damage Response ...
  • ... Reactome ...
  • ... reactome.
  • In response to DNA damage due to exposure to ultraviolet light or to ionizing radiation, Cdc25A is phosphorylated by Chk1 or Chk2. ... The phosphorylation of Cdc25A at ser-123, in response to DNA damage from ionizing. ... of Cdc25A prevents the normal G1/S transition. ... Cdc25A is required for the activation of the Cyclin E:Cdk2 ...
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Pathway: Nuclear Events (kinase and transcription factor activation)  from Reactome  [24 molecules]
Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07.

Summary:  Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07

  • Nuclear Events (kinase and transcription factor activation) ...
  • ... Reactome ...
  • ... and transcription factor activation) ...
  • ... and activation of transcription factors in the nucleus to initiate new programs of gene expression. ... Use this URL to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID 271828 ...
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Pathway: Homologous recombination repair of replication-independent double-strand breaks  from Reactome  [65 molecules]
Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins.

Summary:  Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures.

  • ... Reactome. ... repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. ... DNA repair and signaling proteins are then recruited to double-strand breaks. ... The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. ... Homologous DNA pairing and strand exchange then occurs ...
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Pathway: Formation of Fibrin Clot (Clotting Cascade)  from Reactome  [100 molecules]
The formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury.

Summary:  The formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to fibrin clot formation are commonly described as a cascade, in which the product of each step is an enzyme or cofactor needed for following reactions to proceed efficiently. The entire clotting cascade can be divided into three portions, the extrinsic pathway, the intrinsic pathway, and the common pathway. The extrinsic pathway begins with the release of tissue factor at the site of vascular injury and leads to the activation of factor X. The intrinsic pathway provides an alternative mechanism for activation of factor X, starting from the activation of factor XII. The common pathway consists of the steps linking the activation of factor X to the formation of a multimeric, cross-linked fibrin clot. Each of these pathways includes not only a cascade of events that generate the catalytic activities needed for clot formation, but also numerous positive and negative regulatory events.

  • ... The extrinsic pathway begins with the release of tissue factor at the site of vascular injury and leads to the activation of factor X. ... The intrinsic pathway provides an alternative mechanism for activation of factor X, starting from the activation of factor XII. ... The common pathway consists of the steps linking the activation of factor X to the formation of a multimeric, cross-linked fibrin. ...Formation of Fibrin Clot (Clotting Cascade) ...
  • ... Reactome ...
  • ... reactome.
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Pathway: Frs2-mediated activation  from Reactome  [59 molecules]
The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.

Summary:  The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.

  • Frs2-mediated activation ...
  • ... Reactome ...
  • ... reactome.
  • The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade. ... to connect to the web page of this instance in Reactome: http://www. ...reactome.
  • ... REACTOME DATABASE ID ...
  • ... Reactome stable ...
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Pathway: Alternative complement activation  from Reactome  [17 molecules]
Reviewed: D'Eustachio, P, 2006-07-03 21:35:13.

Summary:  Reviewed: D'Eustachio, P, 2006-07-03 21:35:13

  • Alternative complement activation ...
  • ... Reactome ...
  • ... reactome.
  • ... participating in alternative pathway activation are C3 (and C3b), the factors B, D, and properdin. ... In the first place, alternative pathway activation is a positive feedback mechanism to increase C3b. ... Then Factor B binds ...
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Pathway: Activation of BH3-only proteins  from Reactome  [27 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • ... Activation of BH3-only proteins ...
  • ... Reactome ...
  • ... reactome.
  • ... -signals like DNA damages. ... Activation of BH3-only proteins directly or indirectly results in the activation of proapoptotic BAX and BAK to trigger cell death.