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Searched for: data_source:MINT [All Organisms, All Data Sources]

Your search has found 30028 relevant records:

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Molecules (30028)
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Protein: NAB2_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [2718 interactions]
Nuclear polyadenylated RNA-binding protein NAB2

Summary:  FUNCTION: This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.

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Protein: HSP82_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [2004 interactions]
ATP-dependent molecular chaperone HSP82

Summary:  FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.

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57%57%
Protein: HSP75_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1593 interactions]
Heat shock protein SSB1

Summary:  FUNCTION: May aid in the passage of the nascent polypeptide chain through the ribosome channel into the cytosol. Such an interaction could be crucial for continuous transport of the polypeptide; could serve to prevent the nascent polypeptide from interfering with translation by clogging the ribosome channel.

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50%50%
Protein: Histone H3 [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1435 interactions]
45%45%
Protein: HSP72_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1274 interactions]
Heat shock protein SSA2

Summary:  FUNCTION: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.

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45%45%
Protein: HSC82_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1271 interactions]
ATP-dependent molecular chaperone HSC82

Summary:  FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction such as CNA2. Undergoes a functional cycle that is linked to its ATPase activity (By similarity). Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.

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42%42%
Protein: RV167_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1125 interactions]
Reduced viability upon starvation protein 167

Summary:  FUNCTION: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.

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42%42%
Protein: YBD2_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1190 interactions]
KH domain-containing protein YBL032W

Summary:  FUNCTION: Could be a member of the hnRNP complexes. MISCELLANEOUS: Present with 15600 molecules/cell in log phase SD medium.

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42%42%
Protein: RPN11_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1256 interactions]
26S proteasome regulatory subunit RPN11

Summary:  FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

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42%42%
Protein: H4_YEAST [Saccharomyces cerevisiae]  from MINT, IntAct, BioGRID  [1202 interactions]
Histone H4

Summary:  FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level.

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