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Searched for: data_source:INTACT [All Organisms, All Data Sources]

Your search has found 8803 relevant records:

Molecules (8803)
Showing Results 1 - 10 of 8,803  | Next 10
100%
Protein: HSP75_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [4403 interactions]
Heat shock protein SSB1

Summary:  FUNCTION: May aid in the passage of the nascent polypeptide chain through the ribosome channel into the cytosol. Such an interaction could be crucial for continuous transport of the polypeptide; could serve to prevent the nascent polypeptide from interfering with translation by clogging the ribosome channel.

80%80%
Protein: HSP71_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [3156 interactions]
Heat shock protein SSA1

Summary:  FUNCTION: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.

69%69%
Protein: NAB2_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [2711 interactions]
Nuclear polyadenylated RNA-binding protein NAB2

Summary:  FUNCTION: This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.

58%58%
Protein: HSP7F_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [2231 interactions]
Heat shock protein homolog SSE1

Summary:  FUNCTION: Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.

49%49%
Protein: HSP72_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [2185 interactions]
Heat shock protein SSA2

Summary:  FUNCTION: May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA2 can participate in the ATP-dependent disassembly of clathrin-coated vesicles.

49%49%
Protein: Polyubiquitin-C [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID  [2515 interactions]
40%40%
Protein: RPN11_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [1573 interactions]
26S proteasome regulatory subunit RPN11

Summary:  FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

36%36%
Protein: HSP82_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [1540 interactions]
ATP-dependent molecular chaperone HSP82

Summary:  FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.

36%36%
Protein: HSP76_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [1517 interactions]
Heat shock protein SSB2

Summary:  FUNCTION: May aid in the passage of the nascent polypeptide chain through the ribosome channel into the cytosol. Such an interaction could be crucial for continuous transport of the polypeptide; could serve to prevent the nascent polypeptide from interfering with translation by clogging the ribosome channel.

34%34%
Protein: GIS2_YEAST [Saccharomyces cerevisiae]  from IntAct, MINT, BioGRID  [1343 interactions]
Zinc finger protein GIS2

Summary:  FUNCTION: May act in the sexual differentiation pathway (By similarity).