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Searched for: data_source:IMID [All Organisms, All Data Sources]

Your search has found 1547 relevant records:

Molecules (1547)
Showing Results 1 - 10 of 1,547  | Next 10
100%
Protein: Growth factor receptor-bound protein 2 [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, IMID, NCI / Nature Pathway Interaction Database  [85 pathways, 1131 interactions]
71%71%
Protein: SRC_HUMAN [Homo sapiens]  from IntAct, MINT, HumanCyc, HPRD, BioGRID, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [91 pathways, 892 interactions]
Proto-oncogene tyrosine-protein kinase Src

Summary:  FUNCTION: Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

61%61%
Protein: PIP3 [Human]  from IMID  [173 interactions]

Summary:  Lipid

60%60%
Protein: EGFR_HUMAN [Homo sapiens]  from IntAct, MINT, HumanCyc, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [75 pathways, 876 interactions]
Epidermal growth factor receptor

Summary:  FUNCTION: Cell surface receptor for EGF, but also for other members of the EGF family, such as TGF-alpha, BTC/betacellulin, AREGAREGB/amphiregulin, HBEGF, GP30 and vaccinia virus growth factor. Ligand binding triggers a conformation change, leading to activation of the kinase and subsequent phosphorylation of down- stream protein kinases. Is involved in the control of cell growth, proliferation and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

57%57%
Protein: CBP_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [60 pathways, 790 interactions]
CREB-binding protein

Summary:  FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone].

57%57%
Protein: CTNB1_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [75 pathways, 706 interactions]
Catenin beta-1

Summary:  FUNCTION: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion.

51%51%
Protein: MDM2_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [88 pathways, 706 interactions]
E3 ubiquitin-protein ligase Mdm2

Summary:  FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

51%51%
Protein: RB_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [74 pathways, 630 interactions]
Retinoblastoma-associated protein

Summary:  FUNCTION: Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.

51%51%
Protein: AKT1_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [139 pathways, 579 interactions]
RAC-alpha serine/threonine-protein kinase

Summary:  FUNCTION: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

51%51%
Protein: FYN_HUMAN [Homo sapiens]  from IntAct, MINT, HumanCyc, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [84 pathways, 652 interactions]
Tyrosine-protein kinase Fyn

Summary:  FUNCTION: Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. COFACTOR: Manganese.