Searched for: data_source:HPRD [All Organisms, All Data Sources]

Summary:  FUNCTION: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. COFACTOR: Binds 1 zinc ion per subunit.

Data Source(s):  Cancer Cell Map, HPRD, MINT, Reactome, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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Summary:  FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

Data Source(s):  Cancer Cell Map, HPRD, MINT, IntAct, BioGRID, NCI / Nature Pathway Interaction Database, IMID

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Summary:  FUNCTION: Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

Data Source(s):  HPRD, MINT, IntAct, BioGRID

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Summary:  FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Data Source(s):  Cancer Cell Map, HPRD, MINT, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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Summary:  FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Also involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. Seems to be involved in IL-17 signaling (By similarity). Mediates activation of NF-kappa-B and JNK. May function as an E3 ubiquitin ligase.

Data Source(s):  Cancer Cell Map, HPRD, MINT, Reactome, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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Summary:  FUNCTION: The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Data Source(s):  Cancer Cell Map, HPRD, MINT, Reactome, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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Summary:  FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Data Source(s):  Cancer Cell Map, HPRD, MINT, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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Summary:  SUBUNIT: Homodimer. Binds SCA1. Binds signal sequences of proteins that are targeted to the endoplasmic reticulum (By similarity).

Data Source(s):  HPRD, MINT, IntAct

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Summary:  SUBUNIT: Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.

Data Source(s):  HPRD, MINT, IntAct, BioGRID

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Summary:  FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Data Source(s):  Cancer Cell Map, HPRD, MINT, Reactome, IntAct, BioGRID, NCI / Nature Pathway Interaction Database

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