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Searched for: data_source:HPRD [All Organisms, All Data Sources]

Your search has found 9839 relevant records:

Molecules (9839)
Showing Results 1 - 10 of 9,839  | Next 10
100%
Protein: Polyubiquitin-C [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID  [2515 interactions]
48%48%
Protein: Growth factor receptor-bound protein 2 [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, IMID, NCI / Nature Pathway Interaction Database  [85 pathways, 1131 interactions]
37%37%
Protein: EP300_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, NCI / Nature Pathway Interaction Database  [85 pathways, 1020 interactions]
Histone acetyltransferase p300

Summary:  FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates the 'Lys-131' residue of ALX1 and acts as its coactivator in the presence of CREBBP. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone].

34%34%
Protein: ESR1_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Cancer Cell Map, NCI / Nature Pathway Interaction Database  [69 pathways, 788 interactions]
Estrogen receptor

Summary:  FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.

34%34%
Protein: SRC_HUMAN [Homo sapiens]  from IntAct, MINT, HumanCyc, HPRD, BioGRID, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [91 pathways, 892 interactions]
Proto-oncogene tyrosine-protein kinase Src

Summary:  FUNCTION: Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

30%30%
Protein: 1433Z_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, NCI / Nature Pathway Interaction Database  [73 pathways, 825 interactions]
14-3-3 protein zeta/delta

Summary:  FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

30%30%
Protein: EGFR_HUMAN [Homo sapiens]  from IntAct, MINT, HumanCyc, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [75 pathways, 876 interactions]
Epidermal growth factor receptor

Summary:  FUNCTION: Cell surface receptor for EGF, but also for other members of the EGF family, such as TGF-alpha, BTC/betacellulin, AREGAREGB/amphiregulin, HBEGF, GP30 and vaccinia virus growth factor. Ligand binding triggers a conformation change, leading to activation of the kinase and subsequent phosphorylation of down- stream protein kinases. Is involved in the control of cell growth, proliferation and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

27%27%
Protein: CBP_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [60 pathways, 790 interactions]
CREB-binding protein

Summary:  FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone].

27%27%
Protein: CTNB1_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Cancer Cell Map, IMID, NCI / Nature Pathway Interaction Database  [75 pathways, 706 interactions]
Catenin beta-1

Summary:  FUNCTION: Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion.

27%27%
Protein: CBL_HUMAN [Homo sapiens]  from IntAct, MINT, HPRD, BioGRID, Reactome, Cancer Cell Map, NCI / Nature Pathway Interaction Database  [84 pathways, 716 interactions]
E3 ubiquitin-protein ligase CBL

Summary:  FUNCTION: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3- kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.