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Searched for: Sca-1 [All Organisms, All Data Sources]

Your search has found 83 relevant records:

Pathways (83)Molecules (7)
Showing Results 1 - 10 of 83  | Next 10
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Pathway: Stimulation of the cell death response by PAK-2p34  from Reactome  [6 molecules]
In response to stress signals, the p21-activated protein kinase PAK-2 stimulates a cell death response characterized by increased cell rounding and apoptotic chromatin condensation (see Jakobi et al.

Summary:  In response to stress signals, the p21-activated protein kinase PAK-2 stimulates a cell death response characterized by increased cell rounding and apoptotic chromatin condensation (see Jakobi et al., 2003). PAK-2 is proteolytically cleaved by caspase-3 producing a constitutively active fragment, PAK-2p34. Following cleavage, PAK-2p34 is autophosphorylated at Thr 402 and transported to the nucleus where it accumulates due to the loss of its nuclear export signal motif (Jakobi et al., 2003). The activity of PAK-2p34 appears to be regulated both by proteosomal degradation (Jakobi et al., 2003) and by association with the GTPase-activating protein PS-GAP/ RHG-10. This interaction inhibits the kinase activity of PAK-2p34 and changes the localization of PAK-2p34 from the nucleus to the perinuclear region (Koeppel et al., 2004). PAK-2p34 may function in the down-regulation of translation initiation in apoptosis through phosphorylation of Mnk1 (Orton et al.,2004).

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: SMAC-mediated apoptotic response  from Reactome  [15 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: SMAC binds to IAPs  from Reactome  [14 molecules]
SMAC binds to the XIAP:caspase complexes.

Summary:  SMAC binds to the XIAP:caspase complexes.

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Activation of caspases through apoptosome-mediated cleavage  from Reactome  [12 molecules]
Authored: Alnemri, E, 2004-02-17 00:23:30.

Summary:  Authored: Alnemri, E, 2004-02-17 00:23:30

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: SMAC-mediated dissociation of IAP:caspase complexes  from Reactome  [15 molecules]
Smac/DIABLO regulates IAP function.

Summary:  Smac/DIABLO regulates IAP function. Residues 56–59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to XIAP thus displaces caspase-9 from the XIAP:Caspase complex (reviewed in Salvesen et al., 2002).

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Cytochrome c-mediated apoptotic response  from Reactome  [13 molecules]
Reviewed: Vaux, D, 0000-00-00 00:00:00.

Summary:  Reviewed: Vaux, D, 0000-00-00 00:00:00

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Role of DCC in regulating apoptosis  from Reactome  [17 molecules]
Authored: Garapati, P V, 2008-07-16 14:42:16.

Summary:  Authored: Garapati, P V, 2008-07-16 14:42:16

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Apoptotic cleavage of cell adhesion proteins  from Reactome  [20 molecules]
Apoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al.

Summary:  Apoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion molecules including desmoglein-3, plakophilin-1 and desmoplakin are cleaved by caspases after onset of apoptosis (Weiske et al., 2001). Cleavage results in the disruption of the desmosome structure and thus contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001).

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Apoptosis induced DNA fragmentation  from Reactome  [25 molecules]
Reviewed: Widlak, P, 2008-04-25 14:11:44.

Summary:  Reviewed: Widlak, P, 2008-04-25 14:11:44

  • Pathway contains a molecule or protein with the keyword: SCA-1.
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Pathway: Caspase-mediated cleavage of cytoskeletal proteins  from Reactome  [15 molecules]
Edited: Matthews, L, 2008-04-13 23:06:00.

Summary:  Edited: Matthews, L, 2008-04-13 23:06:00

  • Pathway contains a molecule or protein with the keyword: SCA-1.