PALB2_HUMAN
protein
RefSeq Protein
NP_078951
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_078951
UniProt
Q9H6W1
http://www.uniprot.org/entry/Q9H6W1
UniProt
A6NIE1
http://www.uniprot.org/entry/A6NIE1
Gene Symbol
PALB2
UniProt
Q86YC2
http://www.uniprot.org/entry/Q86YC2
Entrez Gene
79728
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=79728
UniProt
Q8N7Y6
http://www.uniprot.org/entry/Q8N7Y6
UniProt
Q8ND31
http://www.uniprot.org/entry/Q8ND31
to recruit <B><b>BRCA2</b></B> and RAD51 to DNA breaks. of <B><b>BRCA2</b></B> that promotes the localization and stability of <B><b>BRCA2</b></B>. Also enables its recombinational repair and checkpoint functions of <B><b>BRCA2</b></B>. May act by promoting stable association of <B><b>BRCA2</b></B> with nuclear structures, allowing <B><b>BRCA2</b></B> to escape the effects of proteasome-mediated degradation. of a trimeric complex containing BRCA1, <B><b>BRCA2</b></B> and PALB2.
N/A
Homo sapiens
DNA Repair
Reactome
Fanconi Anemia pathway
Reactome
Fanconi anemia pathway
NCI / Nature Pathway Interaction Database
ATM pathway
NCI / Nature Pathway Interaction Database
ATR signaling pathway
NCI / Nature Pathway Interaction Database
BCCIP_HUMAN
protein
P21- and CDK-associated protein 1
Protein TOK-1
UniProt
Q9P288
http://www.uniprot.org/entry/Q9P288
Entrez Gene
56647
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=56647
RefSeq Protein
NP_057651
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_057651
UniProt
Q9P287
http://www.uniprot.org/entry/Q9P287
UniProt
Q96GC4
http://www.uniprot.org/entry/Q96GC4
RefSeq Protein
NP_510869
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_510869
RefSeq Protein
NP_510868
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_510868
Gene Symbol
BCCIP
UniProt
Q8ND15
http://www.uniprot.org/entry/Q8ND15
May be required for repair of DNA damage by homologous recombination in conjunction with <B><b>BRCA2</b></B>. SUBUNIT: Interacts with <B><b>BRCA2</b></B>, CDKN1A and MTDH/LYRIC. Note=Colocalizes with <B><b>BRCA2</b></B> in discrete nuclear foci.
<B><b>BRCA2</b></B> and CDKN1A-interacting protein
N/A
Homo sapiens
BRCA2_HUMAN
protein
Fanconi anemia group D1 protein
UniProt
O15008
http://www.uniprot.org/entry/O15008
UniProt
O00183
http://www.uniprot.org/entry/O00183
RefSeq Protein
NP_000050
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_000050
Gene Symbol
BRCA2
UniProt
Q5TBJ7
http://www.uniprot.org/entry/Q5TBJ7
UniProt
Q13879
http://www.uniprot.org/entry/Q13879
UniProt
P51587
http://www.uniprot.org/entry/P51587
Entrez Gene
675
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=675
, <B><b>BRCA2</b></B> and PALB2. DISEASE: Defects in <B><b>BRCA2</b></B> are a cause of susceptibility to breast. DISEASE: Defects in <B><b>BRCA2</b></B> DISEASE: Defects in <B><b>BRCA2</b></B> are a cause of susceptibility to breast- ovarian cancer. in <B><b>BRCA2</b></B> are the cause of Fanconi anemia complementation group D type 1 (FANCD1) [MIM:605724
N/A
Homo sapiens
DNA Repair
Reactome
Homologous Recombination Repair
Reactome
Double-Strand Break Repair
Reactome
Homologous recombination repair of replication-independent double-strand breaks
Reactome
Homologous DNA pairing and strand exchange
Reactome
Presynaptic phase of homologous DNA pairing and strand exchange
Reactome
Fanconi Anemia pathway
Reactome
Meiotic Recombination
Reactome
Meiosis
Reactome
Validated transcriptional targets of deltaNp63 isoforms
NCI / Nature Pathway Interaction Database
Fanconi anemia pathway
NCI / Nature Pathway Interaction Database
p63 transcription factor network
NCI / Nature Pathway Interaction Database
p73 transcription factor network
NCI / Nature Pathway Interaction Database
FOXM1 transcription factor network
NCI / Nature Pathway Interaction Database
ATM pathway
NCI / Nature Pathway Interaction Database
ATR signaling pathway
NCI / Nature Pathway Interaction Database
BRCA2(IV)
protein
MEE43
F6N15_14
At4g00020
breast cancer 2 like 2A
F6N15.14
EDA20
maternal effect embryo arrest 43
BRCA2A
embryo sac development arrest 20
protein genbank identifier
31335360
nucleotide genbank identifier
186511377
protein genbank identifier
186511378
nucleotide genbank identifier
238480141
RefSeq Protein
NP_191913
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_191913
UniProt
Q7Y1C5
http://www.uniprot.org/entry/Q7Y1C5
protein genbank identifier
75146046
Entrez Gene
828230
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=828230
grid
13519
protein genbank identifier
238480142
protein genbank identifier
CAD32571
RefSeq Protein
NP_001154192
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_001154192
TAIR
AT4G00020
<b>BRCA2</b>A
<B><b>BRCA2</b></B>(IV)
N/A
Arabidopsis thaliana (Mouse-ear cress)
RAD51:BRCA2 complex
complex
Reactome
REACT_4224
http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_4224
Reactome Database ID
83621
RAD51:<B><b>BRCA2</b></B> complex [nucleoplasm]
RAD51:<B><b>BRCA2</b></B> complex
N/A
Homo sapiens
DNA Repair
Reactome
Homologous Recombination Repair
Reactome
Double-Strand Break Repair
Reactome
Homologous recombination repair of replication-independent double-strand breaks
Reactome
Homologous DNA pairing and strand exchange
Reactome
Presynaptic phase of homologous DNA pairing and strand exchange
Reactome
BRCA1:BRCA2:PALB2
complex
Reactome Database ID
517917
Reactome
REACT_21702
http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_21702
BRCA1:<B><b>BRCA2</b></B>:PALB2 [nucleoplasm]
BRCA1:<B><b>BRCA2</b></B>:PALB2
N/A
Homo sapiens
DNA Repair
Reactome
Fanconi Anemia pathway
Reactome
PALB2_MOUSE
protein
Entrez Gene
233826
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=233826
UniProt
Q7TMQ4
http://www.uniprot.org/entry/Q7TMQ4
UniProt
Q6NZG9
http://www.uniprot.org/entry/Q6NZG9
UniProt
Q3U0P1
http://www.uniprot.org/entry/Q3U0P1
Gene Symbol
Palb2
UniProt
Q8CEA9
http://www.uniprot.org/entry/Q8CEA9
RefSeq Protein
NP_001074707
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_001074707
role in homologous recombination repair (HRR) through its ability to recruit <B><b>BRCA2</b></B> and RAD51 to DNA. Essential partner of <B><b>BRCA2</b></B> that promotes the localization and stability of <B><b>BRCA2</b></B>. Also enables its recombinational repair and checkpoint functions of <B><b>BRCA2</b></B>. May act by promoting stable association of <B><b>BRCA2</b></B> with nuclear structures, allowing <B><b>BRCA2</b></B>. complex containing BRCA1, <B><b>BRCA2</b></B> and PALB2.
N/A
Mus musculus
BCCIP_MOUSE
protein
Gene Symbol
Bccip
RefSeq Protein
NP_079668
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_079668
Entrez Gene
66165
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=66165
UniProt
Q9CWI3
http://www.uniprot.org/entry/Q9CWI3
UniProt
Q9D1E0
http://www.uniprot.org/entry/Q9D1E0
<B><b>BRCA2</b></B> and CDKN1A-interacting protein
May be required for repair of DNA damage by homologous recombination in conjunction with <B><b>BRCA2</b></B>. SUBUNIT: Interacts with <B><b>BRCA2</b></B>, CDKN1A and MTDH/LYRIC (By similarity). Note=Colocalizes with <B><b>BRCA2</b></B> in discrete nuclear foci (By similarity).
N/A
Mus musculus
BRCA2_MOUSE
protein
Fanconi anemia group D1 protein homolog
Gene Symbol
Brca2
RefSeq Protein
NP_001074470
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_001074470
UniProt
O35922
http://www.uniprot.org/entry/O35922
RefSeq Protein
NP_033895
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_033895
UniProt
P97929
http://www.uniprot.org/entry/P97929
Entrez Gene
12190
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=12190
UniProt
P97383
http://www.uniprot.org/entry/P97383
complex containing BRCA1, <B><b>BRCA2</b></B> and PALB2. SIMILARITY: Contains 7 <B><b>BRCA2</b></B> repeats.
<b>BRCA2</b>_MOUSE
<B><b>Brca2</b></B>
N/A
Mus musculus
BRCA1_HUMAN
protein
RING finger protein 53
6.3.2.-
RefSeq Protein
NP_009225
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_009225
UniProt
Q3LRJ0
http://www.uniprot.org/entry/Q3LRJ0
UniProt
Q7KYU9
http://www.uniprot.org/entry/Q7KYU9
UniProt
P38398
http://www.uniprot.org/entry/P38398
Entrez Gene
672
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=search&term=672
UniProt
O15129
http://www.uniprot.org/entry/O15129
Gene Symbol
BRCA1
RefSeq Protein
NP_009231
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_009231
RefSeq Protein
NP_009229
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_009229
RefSeq Protein
NP_009228
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=NP_009228
Part of a trimeric complex containing BRCA1, <B><b>BRCA2</b></B> and PALB2. Interacts with <B><b>BRCA2</b></B>
N/A
Homo sapiens
DNA Repair
Reactome
Homologous Recombination Repair
Reactome
Double-Strand Break Repair
Reactome
ATM mediated response to DNA double-strand break
Reactome
Homologous recombination repair of replication-independent double-strand breaks
Reactome
ATM mediated phosphorylation of repair proteins
Reactome
Recruitment of repair and signaling proteins to double-strand breaks
Reactome
Fanconi Anemia pathway
Reactome
Meiotic Synapsis
Reactome
Meiotic Recombination
Reactome
Meiosis
Reactome
Wnt signaling network
NCI / Nature Pathway Interaction Database
Validated targets of C-MYC transcriptional repression
NCI / Nature Pathway Interaction Database
Syndecan-1-mediated signaling events
NCI / Nature Pathway Interaction Database
Regulation of CDC42 activity
NCI / Nature Pathway Interaction Database
Glypican pathway
NCI / Nature Pathway Interaction Database
GMCSF-mediated signaling events
NCI / Nature Pathway Interaction Database
Insulin Pathway
NCI / Nature Pathway Interaction Database
C-MYC pathway
NCI / Nature Pathway Interaction Database
Stabilization and expansion of the E-cadherin adherens junction
NCI / Nature Pathway Interaction Database
FOXA transcription factor networks
NCI / Nature Pathway Interaction Database
Glypican 3 network
NCI / Nature Pathway Interaction Database
Nectin adhesion pathway
NCI / Nature Pathway Interaction Database
TRAIL signaling pathway
NCI / Nature Pathway Interaction Database
IGF1 pathway
NCI / Nature Pathway Interaction Database
PLK1 signaling events
NCI / Nature Pathway Interaction Database
ATF-2 transcription factor network
NCI / Nature Pathway Interaction Database
CDC42 signaling events
NCI / Nature Pathway Interaction Database
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
NCI / Nature Pathway Interaction Database
Glypican 1 network
NCI / Nature Pathway Interaction Database
N-cadherin signaling events
NCI / Nature Pathway Interaction Database
PDGF receptor signaling network
NCI / Nature Pathway Interaction Database
Integrin family cell surface interactions
NCI / Nature Pathway Interaction Database
Fanconi anemia pathway
NCI / Nature Pathway Interaction Database
BARD1 signaling events
NCI / Nature Pathway Interaction Database
Coregulation of Androgen receptor activity
NCI / Nature Pathway Interaction Database
Internalization of ErbB1
NCI / Nature Pathway Interaction Database
Posttranslational regulation of adherens junction stability and dissassembly
NCI / Nature Pathway Interaction Database
Signaling events mediated by VEGFR1 and VEGFR2
NCI / Nature Pathway Interaction Database
Beta1 integrin cell surface interactions
NCI / Nature Pathway Interaction Database
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
NCI / Nature Pathway Interaction Database
Signaling by Aurora kinases
NCI / Nature Pathway Interaction Database
Validated nuclear estrogen receptor alpha network
NCI / Nature Pathway Interaction Database
Polo-like kinase signaling events in the cell cycle
NCI / Nature Pathway Interaction Database
IFN-gamma pathway
NCI / Nature Pathway Interaction Database
Regulation of RAC1 activity
NCI / Nature Pathway Interaction Database
PAR1-mediated thrombin signaling events
NCI / Nature Pathway Interaction Database
Noncanonical Wnt signaling pathway
NCI / Nature Pathway Interaction Database
PDGFR-beta signaling pathway
NCI / Nature Pathway Interaction Database
Canonical Wnt signaling pathway
NCI / Nature Pathway Interaction Database
E-cadherin signaling in the nascent adherens junction
NCI / Nature Pathway Interaction Database
Integrin-linked kinase signaling
NCI / Nature Pathway Interaction Database
Regulation of nuclear beta catenin signaling and target gene transcription
NCI / Nature Pathway Interaction Database
EGF receptor (ErbB1) signaling pathway
NCI / Nature Pathway Interaction Database
Thrombin/protease-activated receptor (PAR) pathway
NCI / Nature Pathway Interaction Database
Class I PI3K signaling events
NCI / Nature Pathway Interaction Database
Arf6 signaling events
NCI / Nature Pathway Interaction Database
Plasma membrane estrogen receptor signaling
NCI / Nature Pathway Interaction Database
IL3-mediated signaling events
NCI / Nature Pathway Interaction Database
AP-1 transcription factor network
NCI / Nature Pathway Interaction Database
mTOR signaling pathway
NCI / Nature Pathway Interaction Database
RAC1 signaling pathway
NCI / Nature Pathway Interaction Database
ErbB receptor signaling network
NCI / Nature Pathway Interaction Database
Signaling events mediated by focal adhesion kinase
NCI / Nature Pathway Interaction Database
VEGF and VEGFR signaling network
NCI / Nature Pathway Interaction Database
Alpha9 beta1 integrin signaling events
NCI / Nature Pathway Interaction Database
Arf6 downstream pathway
NCI / Nature Pathway Interaction Database
S1P1 pathway
NCI / Nature Pathway Interaction Database
FOXA1 transcription factor network
NCI / Nature Pathway Interaction Database
ATM pathway
NCI / Nature Pathway Interaction Database
ErbB1 downstream signaling
NCI / Nature Pathway Interaction Database
EGFR-dependent Endothelin signaling events
NCI / Nature Pathway Interaction Database
Syndecan-4-mediated signaling events
NCI / Nature Pathway Interaction Database
ATR signaling pathway
NCI / Nature Pathway Interaction Database
Arf6 trafficking events
NCI / Nature Pathway Interaction Database
E-cadherin signaling events
NCI / Nature Pathway Interaction Database
Androgen-mediated signaling
NCI / Nature Pathway Interaction Database
Endothelins
NCI / Nature Pathway Interaction Database
E2F transcription factor network
NCI / Nature Pathway Interaction Database
IL5-mediated signaling events
NCI / Nature Pathway Interaction Database
Sphingosine 1-phosphate (S1P) pathway
NCI / Nature Pathway Interaction Database
Regulation of Androgen receptor activity
NCI / Nature Pathway Interaction Database
Proteoglycan syndecan-mediated signaling events
NCI / Nature Pathway Interaction Database
Aurora A signaling
NCI / Nature Pathway Interaction Database
RhoA signaling pathway
NCI / Nature Pathway Interaction Database
Class I PI3K signaling events mediated by Akt
NCI / Nature Pathway Interaction Database
LKB1 signaling events
NCI / Nature Pathway Interaction Database
Regulation of RhoA activity
NCI / Nature Pathway Interaction Database
AndrogenReceptor
Cancer Cell Map