Signal transduction protein CBL-C
SUBUNIT: Interacts with a restricted range of SH3 domain proteins.
SUBCELLULAR LOCATION: Nucleus (Potential).
ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9ULV8-1; Sequence=Displayed; Name=Short; IsoId=Q9ULV8-2; Sequence=VSP_005732;
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
DOMAIN: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity).
PTM: Phosphorylated on tyrosines by EGFR. MISCELLANEOUS: This protein has one functional calcium-binding site (By similarity).
SIMILARITY: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.
SIMILARITY: Contains 1 RING-type zinc finger. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CBLcID194.html";
GENE SYNONYMS: CBL3 RNF57.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.