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Protein: MED23_HUMAN

Mediator of RNA polymerase II transcription subunit 23

FUNCTION: Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. more...

SUBUNIT: Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein.

SUBCELLULAR LOCATION: Nucleus (Probable).

ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Experimental confirmation may be lacking for some isoforms; Name=1; IsoId=Q9ULK4-1; Sequence=Displayed; Name=2; IsoId=Q9ULK4-2; Sequence=VSP_004034, VSP_004036, VSP_004037; Name=3; IsoId=Q9ULK4-3; Sequence=VSP_004034, VSP_004035; Name=4; IsoId=Q9ULK4-4; Sequence=VSP_004035; Name=5; IsoId=Q9ULK4-5; Sequence=VSP_028380;

SIMILARITY: Belongs to the Mediator complex subunit 23 family.

SEQUENCE CAUTION: Sequence=AAD12724.1; Type=Erroneous initiation; Sequence=AAD31729.1; Type=Frameshift; Positions=945, 950; Sequence=BAA86530.1; Type=Erroneous initiation; Sequence=CAB92073.1; Type=Erroneous initiation;

GENE SYNONYMS: ARC130 CRSP3 DRIP130 KIAA1216 SUR2.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • MED23

Synonyms:

  • Cofactor required for Sp1 transcriptional activation subunit 3
  • Protein sur-2 homolog
  • CRSP complex subunit 3
  • DRIP130
  • Transcriptional coactivator CRSP130
  • Vitamin D3 receptor-interacting protein complex 130 kDa component
  • ARC130
  • Mediator complex subunit 23
  • hSur-2
  • Activator-recruited cofactor 130 kDa component

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