Protein: HIF1N_HUMAN
Hypoxia-inducible factor 1-alpha inhibitor
SUBUNIT: Homodimer. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Contains 1 JmjC domain.
GENE SYNONYMS: FIH1.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Homo sapiens
Gene Symbol:
- HIF1AN
Synonyms:
- FIH-1
- Factor inhibiting HIF-1
- Hypoxia-inducible factor asparagine hydroxylase
- 1.14.11.16
Links:
Stable Link:
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FUNCTION: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. CATALYTIC ACTIVITY: Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2). COFACTOR: Iron. more...