Protein: GTR9_HUMAN
Solute carrier family 2, facilitated glucose transporter member 9
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRM0-1; Sequence=Displayed; Name=2; Synonyms=GLUT9deltaN; IsoId=Q9NRM0-2; Sequence=VSP_034860; Note=Variant in position: 17:A->T (in dbSNP:6820230);
TISSUE SPECIFICITY: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level). POLYMORPHISM: Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations [MIM:612076]. Excess serum accumulation of uric acid can lead to the development of gout.
SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
GENE SYNONYMS: GLUT9.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Homo sapiens
Gene Symbol:
- SLC2A9
Synonyms:
- GLUT-9
- Glucose transporter type 9
Links:
Stable Link:
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FUNCTION: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. more...