Protein: PEG3_HUMAN
Paternally-expressed gene 3 protein
SUBUNIT: Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity).
ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9GZU2-1; Sequence=Displayed; Name=2; IsoId=Q9GZU2-2; Sequence=VSP_020371; Name=3; IsoId=Q9GZU2-3; Sequence=VSP_020372, VSP_020373, VSP_020374;
TISSUE SPECIFICITY: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 12 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.
SEQUENCE CAUTION: Sequence=BAB85588.1; Type=Frameshift; Positions=Several; Sequence=CAI45975.1; Type=Erroneous initiation;
GENE SYNONYMS: KIAA0287 ZSCAN24.
COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
Organism:
- Homo sapiens
Gene Symbol:
- PEG3
Synonyms:
- Zinc finger and SCAN domain-containing protein 24
Links:
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FUNCTION: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. more...