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Protein: LGAT1_HUMAN

Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

FUNCTION: Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. more...

SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.

TISSUE SPECIFICITY: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.

DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity).

SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

SEQUENCE CAUTION: Sequence=BAA13196.2; Type=Erroneous initiation;

GENE SYNONYMS: FAM34A KIAA0205.

COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.

No pathway or interaction information available for this record.

 

Organism:

  • Homo sapiens

Gene Symbol:

  • LPGAT1

Synonyms:

  • 2.3.1.-

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